A5014850022- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pharmaceutical studies and practices
- Respiratory and Cough-Related Research
- Urinary Bladder and Prostate Research
- Venous Thromboembolism Diagnosis and Management
- Pediatric health and respiratory diseases
- Child and Adolescent Health
- Heparin-Induced Thrombocytopenia and Thrombosis
- Health Systems, Economic Evaluations, Quality of Life
- Allergic Rhinitis and Sensitization
- Inhalation and Respiratory Drug Delivery
- Respiratory Support and Mechanisms
- Antibiotic Use and Resistance
- Pharmacovigilance and Adverse Drug Reactions
- Pharmaceutical Economics and Policy
- Pharmaceutical Practices and Patient Outcomes
- Delphi Technique in Research
- Gastroesophageal reflux and treatments
- Platelet Disorders and Treatments
- Machine Learning in Healthcare
- Pneumonia and Respiratory Infections
- Urinary Tract Infections Management
- Pelvic floor disorders treatments
- Drug-Induced Hepatotoxicity and Protection
Erasmus MC
2016-2025
Erasmus University Rotterdam
2015-2024
Onze Lieve Vrouwziekenhuis Hospital
2006-2024
Ghent University
2017-2024
University of Dundee
2023
Uppsala University
2023
Institute for Medical Informatics and Biostatistics
2022
Advisory Board Company (United States)
2021
CHR Verviers
2021
Rotterdam University of Applied Sciences
2013-2020
<h3>Background</h3> Patients with severe asthma are at increased risk of exacerbations and lower respiratory tract infections (LRTI). Severe is heterogeneous, encompassing eosinophilic non-eosinophilic (mainly neutrophilic) phenotypes. neutropilic airway diseases may benefit from macrolides. <h3>Methods</h3> We performed a randomised double-blind placebo-controlled trial in subjects exacerbation-prone asthma. Subjects received low-dose azithromycin (n=55) or placebo (n=54) as add-on...
COPD is the third leading cause of death in world and its global burden predicted to increase further. Even though prevalence well studied, only few studies examined incidence a prospective standardized manner. In population-based cohort study (Rotterdam Study) enrolling subjects aged ≥45, was diagnosed based on pre-bronchodilator obstructive spirometry (FEV1/FVC < 0.70). absence an interpretable within Rotterdam Study, cases were defined as having by physician basis clinical presentation...
Abstract Objective To quantify the background incidence rates of 15 prespecified adverse events special interest (AESIs) associated with covid-19 vaccines. Design Multinational network cohort study. Setting Electronic health records and claims data from eight countries: Australia, France, Germany, Japan, Netherlands, Spain, United Kingdom, States, mapped to a common model. Participants 126 661 070 people observed for at least 365 days before 1 January 2017, 2018, or 2019 13 databases. Main...
ABSTRACT In this international study, we examined the incidence of hip fractures, postfracture treatment, and all‐cause mortality following based on demographics, geography, calendar year. We used patient‐level healthcare data from 19 countries regions to identify patients aged 50 years older hospitalized with a fracture 2005 2018. The age‐ sex‐standardized rates post‐hip treatment (defined as proportion receiving anti‐osteoporosis medication various mechanisms action [bisphosphonates,...
The WHO Access, Watch and Reserve (AWaRe) classification has been developed to support countries hospitals in promoting rational use of antibiotics while improving access these essential medicines. We aimed describe patterns worldwide antibiotic according the AWaRe adult inpatient population.The Global Point Prevalence Survey on Antimicrobial Consumption Resistance (Global-PPS) collects hospital data using a standardized PPS methodology. Global-PPS 2015, 2017 2018 data, collected by 664 69...
BackgroundThere are few data on the incidence of thrombosis among COVID-19 cases, with most research concentrated hospitalised patients. We aimed to estimate venous thromboembolism, arterial and death cases assess impact these events risks hospitalisation death.MethodsWe conducted a distributed network cohort study using primary care records from Netherlands, Italy, Spain, UK, outpatient specialist Germany. The Spanish database was linked hospital admissions. Participants were followed up...
<b>Objective</b> To provide an overview of drug use in children three European countries. <b>Design</b> Retrospective cohort study, 2000-5. <b>Setting</b> Primary care research databases the Netherlands (IPCI), United Kingdom (IMS-DA), and Italy (Pedianet). <b>Participants</b> 675 868 aged up to 14 (Italy) or 18 (UK Netherlands). <b>Main outcome measure</b> Prevalence per year calculated by class (anatomical therapeutic). “recurrent/chronic” (three more prescriptions a year) “non-recurrent”...
In 1997, Beers and colleagues developed explicit criteria for potentially inappropriate drug prescribing in ambulatory older adults aged 65 years over. Several studies have been performed to estimate the prevalence of based on these criteria. 2002, were updated.To examine extent trend Netherlands between 1997 2001, according updated criteria.Data retrieved from Integrated Primary Care Information (IPCI) project, a general practice research database with data computer-based patient records...
To evaluate the extent, characteristics and determinants of adverse drug reaction (ADR)-related hospitalisations on a population-based level in 2003.We performed cohort study Integrated Primary Care Information (IPCI) database, general practitioners (GPs) research database with longitudinal data from electronic patient records group 150 GP throughout Netherlands. Hospital discharge letters were reviewed to ADR-related applying WHO causality criteria. The prevalence per total admissions...
Immune checkpoint inhibitors (ICIs) have proven effective in the treatment of numerous cancers; however, they been associated with immune-related adverse events (irAEs), among which cytokine release syndrome (CRS) has reported a few case reports. To describe burden ICI-related CRS and raise awareness as irAE, we queried VigiBase, World Health Organization global database spontaneously suspected drug reactions (ADRs), retrieved safety reports ICIs, gathered through January 12th 2020. We...
Data resource basics Dutch primary care data for researchAccessibility of health is very good in The Netherlands.More than 99% the population has insurance 1 and almost all citizens are registered with a general practitioner (GP).People free to choose their GP.Enrolment at practice can be rejected because capacity limitations or too great distance between patient's address.The GP forms point acts as gatekeeper accessing secondary care.Over 12 months, around 78% least one contact GP. 2...
Epilepsy is associated with increased risk for sudden cardiac death (SCD). We aimed to establish, in a community based study, whether this association mediated by epilepsy per se, use of antiepileptic medications (AEMs), or both.We studied SCD cases and age/sex matched controls case-control study large scale general practitioners' research database (n=478 661 patients). symptomatic (seizure <2 years before SCD), stable (no seizure AEMs (any indication) was determined.We identified 926 9832...