A5082012307- Dementia and Cognitive Impairment Research
- Pharmaceutical Practices and Patient Outcomes
- Schizophrenia research and treatment
- Health Systems, Economic Evaluations, Quality of Life
- Blood Pressure and Hypertension Studies
- Parkinson's Disease Mechanisms and Treatments
- Bone health and osteoporosis research
- Health disparities and outcomes
- Hip and Femur Fractures
- Alzheimer's disease research and treatments
- Chronic Disease Management Strategies
- Pelvic floor disorders treatments
- Pharmacological Effects and Toxicity Studies
- Epilepsy research and treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Intensive Care Unit Cognitive Disorders
- Opioid Use Disorder Treatment
- Diet and metabolism studies
- Pain Management and Opioid Use
- Vitamin D Research Studies
- Medication Adherence and Compliance
- Anorectal Disease Treatments and Outcomes
- Frailty in Older Adults
- Menopause: Health Impacts and Treatments
- Gastroesophageal reflux and treatments
University of Eastern Finland
2016-2025
Finland University
2015-2024
Päijät-Hämeen Keskussairaala
2022
University of Helsinki
2017-2022
Monash University
2022
Tampere University
2020
Central Finland Health Care District
2020
Karolinska Institutet
2013-2020
Niuvanniemi Hospital
2014-2020
Stockholm County Council
2020
Background: Obesity has been consistently associated with dementia. The role of certain risk factors dementia may change during life, and the importance having a life-course perspective acknowledged. Objective: aim this study wa
Physical activity may be beneficial for cognition, but the effect vary depending on personal characteristics.We investigated associations between leisure-time physical (LTPA) from mid- to late life, risk of dementia, and role body mass index, sex, APOE in CAIDE study during 28-year follow-up. Cognitive function a random subsample was assessed at mean age 78.8 years (n = 1511), dementia/Alzheimer's disease (AD) diagnoses were identified national registers entire target population...
ABSTRACT In this international study, we examined the incidence of hip fractures, postfracture treatment, and all‐cause mortality following based on demographics, geography, calendar year. We used patient‐level healthcare data from 19 countries regions to identify patients aged 50 years older hospitalized with a fracture 2005 2018. The age‐ sex‐standardized rates post‐hip treatment (defined as proportion receiving anti‐osteoporosis medication various mechanisms action [bisphosphonates,...
Databases of prescription drug purchases are now widely used in pharmacoepidemiologic studies. Several methods have been to generate use periods from investigate various aspects; e.g., study associations between exposure and outcome. Typically, such fairly simplistic, with fixed assumptions pattern or dose (for example, the assumed usage 1 tablet per day). This paper describes a novel PRE2DUP method that constructs purchase histories, verified by validation based on an expert evaluation...
To explore the association between postmenopausal hormone therapy (HT) and Alzheimer disease (AD).
Abstract Context Type 2 diabetes has been linked with an increased risk of Alzheimer’s disease (AD). Studies on the association between metformin use and AD have reported conflicting results. Objective To investigate whether modifies incident, clinically verified AD. Design Nested case-control study. Setting All community-dwelling people in Finland. Participants Cases were all Finns diagnosed from 2005 to 2011 ≥ 3 years before (n = 9862). matched up control persons by age, sex, duration 19...
Accurate diagnosis of Parkinson disease (PD) remains challenging, with variability and clinical uncertainty, especially in nonspecialized settings. Despite advancements diagnostic criteria biological markers, misdiagnosis continues to affect patient care research. This study aimed assess the long-term stability PD evaluate accuracy initial diagnoses over time a large, consecutive cohort diagnosed by neurologists, or without movement disorder specialization. We conducted retrospective...
The common single-nucleotide polymorphism in the FTO (fat mass and obesity associated) gene is consistently associated with an increased risk of obesity. However, knowledge a potential modifying effect on changes body weight achieved by lifestyle intervention limited. We examined whether variant (rs9939609, T/A) BMI long-term Finnish Diabetes Prevention Study (DPS). Altogether, 522 (aged 40-65 years; >or=25 kg/m(2)) subjects impaired glucose tolerance (IGT) were randomized to control groups....
Vitamin D status is believed to be best indicated by serum 25-hydroxyvitamin [25(OH)D; consisting of 25(OH)D3 and 25(OH)D2] that are obtained from different sources. Suboptimal vitamin common associated with adverse health outcomes. The objectives were report the prevalence risk factors deficiency determine associations characteristics have been shown relate total 25(OH)D 25(OH)D2 concentrations. Avon Longitudinal Study Parents Children a population-based contemporary birth cohort (children...
Evidence is lacking about outcomes associated with the cumulative use of anticholinergic and sedative drugs in people Alzheimer's disease (AD). This retrospective cohort study investigated relationship between exposure to hospitalization mortality without AD Finland.
The aim of the Medicine use and Alzheimer's disease (MEDALZ) study is to investigate changes in medication healthcare service among persons with (AD) evaluate safety effectiveness medications this group. This important, because number AD rapidly growing even though they are a particularly vulnerable patient group, representative, large-scale studies adequate follow-up time limited.MEDALZ contains all residents Finland who received clinically verified diagnosis between 2005 2011 were...
The objective of the study was to investigate whether proton pump inhibitor (PPI) use is associated with an increased risk clinically verified Alzheimer's disease (AD).A Finnish nationwide nested case-control MEDALZ includes all community-dwelling individuals newly diagnosed AD during 2005-2011 (N=70,718), and up four age-, sex-, region residence-matched comparison for each case (N=282,858). Data were extracted from health-care registers. PPI derived purchases recorded in Prescription...
Psychotropic drugs are used for treatment of behavioral and psychological symptoms dementia (BPSD) although they associated with serious adverse drug events. Objective our study was to investigate prevalence psychotropic use one year after diagnoses Alzheimer's disease (AD), compare persons without AD assess changes in over time. Data from the MEDALZ (Medication disease) cohort utilized including all 69,080 community-dwelling new diagnosis during years 2005-2011 Finland. Four age-, gender-...
Background: PRE2DUP is a modeling method that generates drug use periods (ie, when started and ended) from purchases recorded in dispensing-based register data. It based on the evaluation of personal purchasing patterns considers hospital stays, possible stockpiling drugs, package information. Objective: The objective this study was to investigate person-level agreement between self-reported interview modeled dispensing data with for various classes used by older persons. Methods:...
Depression in adolescence is common and early onset predicts worse outcome adulthood. Studies adults have suggested a link between higher total 25-hydroxyvitamin D [25(OH)D] concentrations lower risk of depression. To investigate (a) the association serum 25(OH)D(2) 25(OH)D(3) depressive symptoms children, (b) whether associations are different from, independent of, each other. Prospective cohort study with measured at mean age 9.8 years assessed Mood Feelings Questionnaire by trained...
Stroke increases the risk of dementias, including Alzheimer disease (AD), but it is unknown whether persons with AD have a higher strokes. We investigated noninstitutionalized were more likely to experience incident stroke than without and there are differences in incidence ischemic or hemorrhagic strokes.We performed register-based matched cohort study all community-dwelling verified clinical diagnosis AD, residing Finland on December 31, 2005, single age-, sex-, region residence-matched...
<h3>BACKGROUND:</h3> Knowledge regarding whether benzodiazepines and similarly acting non-benzodiazepines (Z-drugs) are associated with an increased risk of pneumonia among older adults is lacking. We sought to investigate this association community-dwelling Alzheimer disease, a condition in which both sedative/hypnotic use common. <h3>METHODS:</h3> obtained data on all recent diagnosis disease Finland (2005–2011) from the Medication (MEDALZ) cohort, incorporates national registry...
Objectives To evaluate the association between regular antiepileptic drug (AED) use and incident dementia. Design Case‐control analysis. Setting Finnish public health register German insurance data. Participants Individuals with dementia of any type (German data, N=20,325) Alzheimer's disease (AD; N=70,718) were matched up to four control persons without Measurements We analyzed AED address potential protopathic bias, a lag time 2 years diagnosis was introduced. Odds ratios (ORs) calculated...
Dementia, with Alzheimer's disease (AD) being the most common form, is a major hip fracture risk factor, but currently it not known whether same factors predict among persons and without dementia/AD. We compared predictors of mortality after in AD. An exposure-matched cohort all community-dwellers Finland who received new clinically verified AD diagnosis 2005–2011 had no history previous (N = 67,072) an age, sex, region-matched 67,072). Associations between sociodemographic characteristics,...
ABSTRACT Background PD comorbid with schizophrenia has been considered rare because these diseases associate opposite alterations in the brain dopamine system. The objective of this study was to investigate risk after a diagnosis spectrum disorder. Methods Regionally, retrospective record‐based case–control study. cohort included 3045 patients treated 2004–2019 southwestern Finland. Nationally nested using registers examine Finnish who received clinically confirmed 1996–2015 (n = 22,189)....