A5032320654- Pharmaceutical Practices and Patient Outcomes
- Parkinson's Disease Mechanisms and Treatments
- Nutrition and Health in Aging
- Menopause: Health Impacts and Treatments
- Dysphagia Assessment and Management
- Estrogen and related hormone effects
- Dental Health and Care Utilization
- Blood Pressure and Hypertension Studies
- Diabetes Management and Education
- Schizophrenia research and treatment
- Rheumatoid Arthritis Research and Therapies
- Research in Social Sciences
- Chronic Lymphocytic Leukemia Research
- Frailty in Older Adults
- Dementia and Cognitive Impairment Research
- Cancer-related cognitive impairment studies
- Intensive Care Unit Cognitive Disorders
- Chronic Disease Management Strategies
- Neurological disorders and treatments
- Health Systems, Economic Evaluations, Quality of Life
- Diabetes Treatment and Management
- Restless Legs Syndrome Research
- Oral microbiology and periodontitis research
- Cardiovascular Syncope and Autonomic Disorders
- Pain Management and Opioid Use
University of Eastern Finland
2016-2025
Finland University
2011-2024
ORCID
2024
University of Helsinki
2022-2023
Helsinki University Hospital
2023
Päijät-Hämeen Keskussairaala
2022
Monash University
2022
In-Q-Tel
2016
Identification of sequence variants robustly associated with predisposition to diabetic kidney disease (DKD) has the potential provide insights into pathophysiological mechanisms responsible. We conducted a genome-wide association study (GWAS) DKD in type 2 diabetes (T2D) using eight complementary dichotomous and quantitative phenotypes: principal analysis involved 5,717 T2D subjects, 3,345 DKD. Promising signals were evaluated up 26,827 subjects (12,710 DKD). A combined T1D+T2D GWAS was...
The objective of the study was to investigate whether proton pump inhibitor (PPI) use is associated with an increased risk clinically verified Alzheimer's disease (AD).A Finnish nationwide nested case-control MEDALZ includes all community-dwelling individuals newly diagnosed AD during 2005-2011 (N=70,718), and up four age-, sex-, region residence-matched comparison for each case (N=282,858). Data were extracted from health-care registers. PPI derived purchases recorded in Prescription...
poor oral health is common among older people dependent on supportive care and it affects their quality of life. Cognitive impairment functional dependency may increase the risk compromised daily hygiene. to investigate effectiveness a tailored preventive intervention home clients aged 75 years or over. group comprised 151 patients (84.4 ± 5.6 years) control 118 (84.7 5.2 years). An interview clinical examination were carried out before denture The participants in both groups re-interviewed...
<h3>Background and Objectives</h3> Epidemiologic studies have suggested a link between rheumatoid arthritis Parkinson disease (PD). Disease-modifying antirheumatic drugs (DMARDs) might explain this association. The aim of work was to evaluate the association DMARDs risk PD in persons with arthritis. <h3>Methods</h3> This nested nationwide case-control study conducted within Finnish Parkinson9s Disease (FINPARK) cohort, which includes 22,189 clinically verified diagnosed 1996 2015. cases had...
Background: Helicobacter pylori ( H. ) has been inconsistently associated with risk of Alzheimer disease. The exposure assessment period often overlapped the prodromal time Cognitive disorders might increase vulnerability to infectious pathogens, complicating ascertainment temporal relationship between infection and Methods: This Finnish nested case–control study included 70,520 persons incident disease diagnosed 2005-2011 281,233 age-, sex-, region residence-matched controls. We obtained...
Abstract Objectives The purpose of this study was to examine drug use and other factors associated with xerostomia in home care clients aged 75 years or older. Methods sample included 270 ≥75 living Eastern Central Finland. underwent in‐home interviews carried out by trained nurses, nutritionists, dental hygienists pharmacists. collected data contained information on sociodemographic factors, health oral status, use, depressive symptoms ( GDS ‐15), cognitive functioning MMSE ), functional...
Association between oophorectomy and/or hysterectomy and dementia in context of hormone therapy (HT) use is ambiguous.To assess whether oophorectomy, hysterectomy, with bilateral are related to risk Alzheimer's disease (AD), the possible indication for surgery plays a role, if associations modified by HT.Our nationwide register based case-control (1 : 1) study included all women clinically-verified AD diagnoses, residing Finland on December 31, 2005 (n cases = 19,043, n controls 19,043)....
Frailty is a common problem among older people and it associated with an increased risk of death long-term institutional care. Early identification frailty necessary to prevent further decline in the health status home care clients. The aims present study were determine prevalence factors 75-year-old or participants clients living three cities Eastern Central Finland. Home who had completed abbreviated Comprehensive Geriatric Assessment (aCGA) for (n = 257) included study. Baseline data...
The objective of this study is to describe and analyze adverse drug events (ADE) identified using the Global trigger tool (GTT) in a Finnish tertiary hospital during 5-year period also evaluate whether medication module GTT useful for ADE detection management or if modification needed. A cross-sectional retrospective record review 450-bed Finland. Ten randomly selected patients from electronic medical records were reviewed bimonthly 2017 2021. team total 834 with modified method, which...
Increasing numbers of frail elderly people living at home but dependent on supportive care will face complex oral health challenges.To investigate the associations frailty status with cleaning habits and hygiene taking into account effects preventive intervention among clients aged 75 or over.Data were gathered by interviews clinical examinations baseline after a 6-month follow-up. Frailty was evaluated using abbreviated comprehensive geriatric assessment (aCGA) scale, which consists 15...
Abstract Purpose Diabetes has been associated with increased risk of Parkinson's disease (PD). medications have suggested as a possible explanation, but findings inconsistent. More information on the role exposure in different time windows is needed because PD long onset. We assessed association between use diabetes medication categories and periods. Methods A case–control study restricted to people was performed part nationwide register‐based Finnish (FINPARK). included 2017 cases...
The association between pain and diabetes in older people has been largely unexplored. aim of this survey was to analyze the prevalence characteristics among Finnish men women 65 or with without primary care. All home-dwelling persons years (N = 527) age gender matched controls 890) were identified from electronic patient records. Frequent regarded as any experienced more often than once a week, it divided into several times week but not daily continuously. Numeric Rating Scale (0–10) (NRS)...
Abstract Background With ageing, food intake may decrease and lead to an insufficient nutrient causing protein-energy malnutrition (PEM) which is associated with adverse health effects increased mortality. The aim of this study was investigate the individually tailored dietary counseling focused on protein among home care clients PEM or at risk developing PEM. secondary energy other nutrients. Methods This intervention part non-randomised population-based multidisciplinary Nutrition, Oral...
Although β2-adrenoceptor (β2AR) agonists have been associated with a lower risk of Parkinson's disease (PD), the findings are inconclusive and may reflect confounding by indication. We studied association between inhaled β2AR PD in persons asthma or chronic obstructive pulmonary (COPD).The nested case-control study was conducted within register-based Finnish (FINPARK) included 1406 clinically verified cases diagnosed during 1999-2015, who also had asthma/COPD >3 years before PD. were matched...
To compare discrepancies between in-home interviews and electronic medical records (EMRs) on regularly used prescription drugs among older home care clients.The participants were clients aged 75 years or living in three Finnish municipalities. In-home interview data regular drug use from 276 compared with EMRs. Agreement the EMRs was assessed using Cohen's kappa.A majority (83%, n = 229) of had EMRs, 40% that could clinically compromise their treatment. Living a spouse other family member,...
Abstract Background Antidepressant use is more common in people with Parkinson’s disease (PD), but it unknown when this difference emerges. Methods We studied the incidence of antidepressant six-month periods from 10 years before to 15 after PD diagnosis nationwide register-based Finnish Study on (FINPARK). This study included 20,456 community dwellers clinically verified diagnosed during 1996–2015 and 140,291 matched comparison persons. Results Altogether 44.3% initiated antidepressants,...
We studied the incidence and duration of cumulative bisphosphonate use among older Finnish women men with or without Alzheimer's disease (AD).The MEDALZ-2005 cohort is a nationwide sample all persons clinically diagnosed AD on 31 December 2005 their age-, gender-, region residence-matched control AD.Information by an diagnosis controls during 2002-2009 was obtained from prescription register database containing reimbursed medications.A total 6,041 (11.8%) used bisphosphonates 8-year...
Abstract Aim This study aimed to describe the learning experiences of social and healthcare students professionals an interprofessional large‐group simulation. A simulation on sudden infant death syndrome (SIDS) was organized in collaboration between a Finnish university, university hospital applied sciences. Design case study. Methods The research data were collected at with questionnaire containing variables five‐point Likert scale open questions. filled out by 350 participating...