A5072366449- Schizophrenia research and treatment
- Bipolar Disorder and Treatment
- Neurotransmitter Receptor Influence on Behavior
- Pharmaceutical Practices and Patient Outcomes
- Treatment of Major Depression
- Psychopathy, Forensic Psychiatry, Sexual Offending
- Electroconvulsive Therapy Studies
- Dementia and Cognitive Impairment Research
- Neuroscience and Neuropharmacology Research
- Functional Brain Connectivity Studies
- Substance Abuse Treatment and Outcomes
- Suicide and Self-Harm Studies
- Mental Health Treatment and Access
- Mental Health and Psychiatry
- Opioid Use Disorder Treatment
- Mental Health Research Topics
- Healthcare Decision-Making and Restraints
- Tryptophan and brain disorders
- Receptor Mechanisms and Signaling
- Blood Pressure and Hypertension Studies
- Health Systems, Economic Evaluations, Quality of Life
- Pharmacological Effects and Toxicity Studies
- Personality Disorders and Psychopathology
- Epilepsy research and treatment
- Attention Deficit Hyperactivity Disorder
Niuvanniemi Hospital
2016-2025
University of Eastern Finland
2016-2025
Karolinska Institutet
2016-2025
Stockholm County Council
2017-2025
Stockholm Health Care Services
2019-2025
University of Helsinki
2004-2025
Kuopio University Hospital
2006-2024
Institute for Molecular Medicine Finland
2009-2024
Turku University Hospital
2024
University Medical Center Groningen
2024
Objective: Data on the effectiveness of antipsychotics in early phase schizophrenia are limited. The authors examined risk rehospitalization and drug discontinuation a nationwide cohort 2,588 consecutive patients hospitalized for first time with diagnosis between 2000 2007 Finland. Method: linked national databases hospitalization, mortality, antipsychotic prescriptions computed hazard ratios, adjusting effects sociodemographic clinical variables, temporal sequence used, choice initial each...
It has remained unclear whether there are clinically meaningful differences between antipsychotic treatments with regard to preventing relapse of schizophrenia, owing the impossibility including large unselected patient populations in randomized clinical trials, as well residual confounding from selection biases observational studies.To study comparative real-world effectiveness for patients schizophrenia.Prospectively gathered nationwide databases were linked risk rehospitalization and...
Objective: The purpose of the study was to examine quantitative risk criminal behavior associated with specific mental disorders.Method: An unselected 1966 birth cohort (N=12,058) in Northern Finland prospectively studied until end 1992.The investigation started during mothers' pregnancy, and data on subjects' family characteristics, physical development, living habits, psychiatric morbidity, records were gathered at various times.Results: prevalence offenses highest among males...
Owing to the fact that Finnish police have been able solve about 95% of all homicides during recent decades and because most homicide offenders are subjected an intensive psychiatric evaluation, it was possible examine data on 693 994 8-year period.The prevalences mental disorders were used calculate odds ratios (ORs) for statistical increase in risk associated with specific disorders.The results indicate schizophrenia increases OR homicidal violence by 8-fold men 6.5-fold women. Antisocial...
<h3>Abstract</h3> <b>Objective</b> To study the association between prescribed antipsychotic drugs and outcome in schizophrenia or schizoaffective disorder community. <b>Design</b> Prospective cohort using national central registers. <b>Setting</b> Community care Finland. <b>Participants</b> Nationwide of 2230 consecutive adults hospitalised Finland for first time because disorder, January 1995 to December 2001. <b>Main measures</b> Rates discontinuation (all causes), rates...
Antipsychotics are effective in preventing relapses of schizophrenia, but it is generally believed that their long‐term use harmful for patients’ physical well‐being. However, there no studies which have verified this view. This nationwide, register‐based cohort study aimed to assess the risk hospitalization due health problems, as a marker severe morbidity, and all‐cause mortality, well cardiovascular suicidal death, associated with antipsychotic all patients treated schizophrenia inpatient...
<h3>Importance</h3> The effectiveness of antipsychotic polypharmacy in schizophrenia relapse prevention is controversial, and use multiple agents generally believed to impair physical well-being. <h3>Objective</h3> To study the association specific combinations with psychiatric rehospitalization. <h3>Design, Setting, Participants</h3> In this nationwide cohort study, risk rehospitalization was used as a marker for among 62 250 patients during 29 different monotherapy types between January 1,...
Polypharmacy is widely used in the treatment of schizophrenia, although it believed to have major adverse effects on well-being patients.To investigate if use benzodiazepines, antidepressants, or multiple concomitant antipsychotics associated with increased mortality among patients schizophrenia.Registry-based case linkage study.Academic research.We linked national databases and medication prescriptions a complete nationwide cohort 2588 hospitalized Finland for first time diagnosis...
It has remained controversial if antipsychotic treatment is associated with increased or decreased mortality among patients schizophrenia, and there are any clinically meaningful differences between specific agents routes of administration. We linked prospectively gathered nationwide register-based data during 2006–2013 to study all-cause all aged 16–64 years schizophrenia in Sweden (N = 29,823 total; N 4603 the incident cohort). Multivariate Cox regression models were adjusted for clinical...
Background: It is generally believed that long-term use of antipsychotics increases mortality and, especially, the risk cardiovascular death. However, there are no solid data to substantiate this view. Methods: We identified all individuals in Sweden with schizophrenia diagnoses before year 2006 ( N = 21 492), aged 17–65 years, and persons first-episode during follow-up 2006–2010 1230). Patient information was prospectively collected through nationwide registers. Total cause-specific...
Antisocial behavior (ASB) places a large burden on perpetrators, survivors, and society. Twin studies indicate that half of the variation in this trait is genetic. Specific causal genetic variants have, however, not been identified.
Although mortality related to psychotropic medications has received much attention in recent years, little is known about the relationship between risk of death and cumulative antipsychotic load, even less exposure antidepressants or benzodiazepines. The authors examined these relationships using nationwide databases.The used prospectively collected databases identify all individuals 16-65 years age with a schizophrenia diagnosis (N=21,492) Sweden. All-cause cause-specific rates were...
It is generally believed that after the first episode of schizophrenia, risk relapse decreases with time in patients who are stabilized. Many treatment guidelines recommend stabilization, antipsychotic should be continued for 1-5 years, and longer exposure avoided if possible. However, there no published evidence to substantiate this view. The authors used nationwide databases investigate issue.Prospectively gathered register data were study failure (psychiatric rehospitalization or death)...
Abstract Gender differences in schizophrenia have been reported different aspect of the course disease and may urge special clinical interventions for female patients. Current literature provides insufficient information to design guidelines treating women with schizophrenia. We aim quantify men on premorbid hospitalizations prescription drugs, age at diagnosis, pharmacological treatment, comorbidity, number re-hospitalizations, mortality. Our nationwide cohort study included all patients...
Most evidence about efficacy and safety of antipsychotics in schizophrenia spectrum disorders relies on randomized clinical trials (RCTs). However, owing to their strict eligibility criteria, RCTs represent only a part the real-world population (ie, unselected patients seen everyday practice), which may result an efficacy-effectiveness gap.To quantify proportion individuals with who would be ineligible for participation RCTs, explore whether outcomes differ between eligible individuals.This...
Abstract Compelling evidence suggests that human cognitive function is strongly influenced by genetics. Here, we conduct a large-scale exome study to examine whether rare protein-coding variants impact in the adult population ( n = 485,930). We identify eight genes ADGRB2 , KDM5B GIGYF1 ANKRD12 SLC8A1 RC3H2 CACNA1A and BCAS3 ) are associated with through coding large effects. Rare genetic architecture for partially overlaps of neurodevelopmental disorders. In case show how dosage one these...
Several lines of evidence indicate the involvement neuroinflammatory processes in pathophysiology schizophrenia (SCZ). Microglia are brain resident immune cells responding toward invading pathogens and injury-related products, additionally, have a critical role improving neurogenesis synaptic functions. Aberrant activation microglia SCZ is one leading hypotheses for disease pathogenesis, but due to lack proper human cell models, not well studied. We used monozygotic twins discordant healthy...
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The best pharmacological treatment practices for relapse prevention in patients with first-episode schizophrenia are unclear. We aimed to assess different strategies used before and after the first relapse, their associations subsequent risk. In this population-based cohort study, we enrolled individuals (aged ≤45 years) who were hospitalised subsequently relapsed between 1996 2014 from nationwide Finnish Hospital Discharge Register. Individuals had not been taking antipsychotics within year...