A5009658935- Menopause: Health Impacts and Treatments
- Estrogen and related hormone effects
- Schizophrenia research and treatment
- Reproductive System and Pregnancy
- Electroconvulsive Therapy Studies
- Phytoestrogen effects and research
- Bipolar Disorder and Treatment
- Pelvic floor disorders treatments
- Cancer Risks and Factors
- Cerebrovascular and Carotid Artery Diseases
- Endometriosis Research and Treatment
- Pregnancy and Medication Impact
- Global Cancer Incidence and Screening
- Dementia and Cognitive Impairment Research
- Diabetes Management and Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pharmaceutical Practices and Patient Outcomes
- Multiple Sclerosis Research Studies
- Cardiac Health and Mental Health
- Psychiatric care and mental health services
- Healthcare Decision-Making and Restraints
- Sex and Gender in Healthcare
- Pharmacological Effects and Toxicity Studies
- Anorectal Disease Treatments and Outcomes
- Treatment of Major Depression
Statistics Finland
2020
Antipsychotics are effective in preventing relapses of schizophrenia, but it is generally believed that their long‐term use harmful for patients’ physical well‐being. However, there no studies which have verified this view. This nationwide, register‐based cohort study aimed to assess the risk hospitalization due health problems, as a marker severe morbidity, and all‐cause mortality, well cardiovascular suicidal death, associated with antipsychotic all patients treated schizophrenia inpatient...
<h3>Importance</h3> The effectiveness of antipsychotic polypharmacy in schizophrenia relapse prevention is controversial, and use multiple agents generally believed to impair physical well-being. <h3>Objective</h3> To study the association specific combinations with psychiatric rehospitalization. <h3>Design, Setting, Participants</h3> In this nationwide cohort study, risk rehospitalization was used as a marker for among 62 250 patients during 29 different monotherapy types between January 1,...
To compare the use of hormone therapy between Finnish postmenopausal women with and without a diagnosis for Alzheimer's disease.Nationwide case-control study.Finnish national population drug register, 1999 2013.All (n=84 739) in Finland who, 2013, received disease from neurologist or geriatrician, who were identified register. Control 739), matched by age hospital district, traced register.Data on obtained reimbursement register.Odds ratios 95% confidence intervals disease, calculated...
Mood stabilizers and antipsychotics are the main maintenance treatments for bipolar disorder. Lithium is considered to be most effective mood stabilizer, but very little known about overall health outcomes associated with specific comparative long-term effectiveness of psychotropics or routes administration in prevention rehospitalizations.To study pharmacologic rehospitalization a nationwide cohort patients disorder.This examined risk psychiatric, cardiovascular, all-cause hospitalization...
Objective: Data on the health benefits and risks of postmenopausal hormone therapy (HT) are derived mainly from use conjugated equine estrogens. Estradiol-based regimens may have a different risk-benefit profile. We evaluated risk death caused by coronary heart disease (CHD), stroke, or any among users estradiol-based HT in nationwide study Finland. Methods: A total 489,105 women who used 1994 to 2009 (3.3 million exposure years), as indicated reimbursement register national Cause Death...
Current guidelines recommend annual discontinuation of postmenopausal hormone therapy (HT) to evaluate whether a woman could manage without the treatment. The impact HT on cardiovascular health has been widely studied, but it is not known how withdrawal affects risk.We evaluated risk cardiac or stroke death after HT. Design, Patients, Interventions, and Main Outcome Measures: Altogether 332 202 Finnish women discontinuing between 1994 2009 (data from National Reimbursement register) were...
Data are controversial on the impact of postmenopausal hormone therapy (HT) breast cancer mortality. We analyzed nationwide Finnish data mortality risk in women using HT consisting estradiol-only (ET) or estrogen-progestogen (EPT).In total, 489,105 1994 to 2009, traced from reimbursement register, were followed initiation (3.3 million cumulative exposure years) death (n = 1,578 women). The observed deaths compared with those age-standardized background population.The was reduced all users...
The “window of opportunity hypothesis” refers to data indicating that conjugated equine estrogen alone or in combination with medroxyprogesterone acetate, if initiated before 60 years age, protects the heart but endangers it later (Women's Health Initiative study). Less is known about natural estradiol (ET) various progestins (EPT). We related death risk from coronary disease (CHD) users ET EPT age at initiation therapy and progestin component EPT. Altogether, 498 105 women had used...
There are conflicting data on postmenopausal hormone therapy (HT) and the risk of vascular dementia (VD) Alzheimer's disease (AD).We analyzed mortality attributable to VD or AD in women with a history HT use.Finnish (n = 489,105) using systemic 1994 2009 were identified from nationwide drug reimbursement register. Of these women, 581 died 1057 1998 2009. Observed deaths users <5 ≥5 years exposure compared that occurred age-standardized female population. Furthermore, we death who had started...
To assess whether coronary heart disease mortality in Finnish hormone therapy (HT) users differed before and after 2002 when the Women's Health Initiative study was published.The risks of death HT relation to age-matched background population were compared between pre- (1995-2001) post- (2002-2009) eras. We used a nationwide register on (ie, estradiol with or without progestin) reimbursement linked them causes 290,272 women aged 40 years older.Exposure for 1 year less accompanied by 29%...
Knowledge on the comparative effectiveness of pharmacological treatments to prevent suicide mortality in bipolar disorder is still lacking.We studied risk during 1996-2012 among all patients who had been hospitalized due Finland (n = 18,018; mean follow-up time 7.2 years) using nation-wide databases. We used a Cox proportional hazards model. Analyses were adjusted for effects since diagnosis, order treatments, current use other polypharmacy, number suicidal hospitalizations within 2 year...
Our aim was to estimate and compare the prevalence of adverse pregnancy outcomes among pregnant women with multiple sclerosis (MS) exposed interferon beta (IFNB) MS unexposed any disease-modifying drug (MSDMD).This cohort study used Finnish (1996-2014) Swedish (2005-2014) national register data. Women having IFNB dispensed 6 months before or during as only medication were considered (only IFNB-exposed), whereas MSDMD (MSDMD-unexposed). Prevalence described compared using log-binomial...
Does the use of post-menopausal vaginal estradiol (VE) affect mortality risk for coronary heart disease (CHD) and stroke. The VE reduces cardiovascular mortality. A growing number women genitourinary symptoms. Although this therapy is intended to have only local effects, estrogen absorbed into blood circulation thus may also systemic effects. We studied a nationwide cohort in Finland 1994–2009 during which (n = 195 756) initiated (age [mean ± SD] 65.7 10.9 years). Follow-up data gathered 1.4...
Abstract Objective: The aim of the study was to evaluate risk cardiac and stroke deaths in women who discontinue postmenopausal hormone therapy (HT). Methods: We analyzed death due ( n = 5,204) cerebrovascular 3,434) causes Finnish discontinued systemic HT during 1994 2013 432,775). risks were compared with those age-matched female background population users. Women diagnosed or events within 1 year before discontinuation excluded 8,711). Results: younger than 60 years at showed a...
Background Interferon-beta (IFN-beta) is a commonly used treatment for multiple sclerosis (MS). Current guidelines recommend cessation of during pregnancy, however the results past studies on safety prenatal exposure to IFN-beta have been conflicting. A large scale study population MS women therefore warranted. Objectives To assess whether, among those born with MS, infants prenatally exposed show evidence smaller size at birth relative which were not any disease modifying drugs. Methods...
Receptors for estrogen and progesterone are present in the pelvic floor, therefore, postmenopausal hormone therapy may affect its function. We compared former use of estradiol-progestogen nonhysterectomized women with a uterine prolapse surgery (N = 12,072) control 33,704).The history operation were identified from Finnish National Hospital Discharge Register, Central Population Register. The was traced national drug reimbursement register, odd ratios 95% CIs calculated by using conditional...