Harshal Deshmukh
A5088604122- Diabetes Management and Research
- Ovarian function and disorders
- Diabetes Treatment and Management
- Genetic Associations and Epidemiology
- Diabetes and associated disorders
- Diabetes Management and Education
- Reproductive Biology and Fertility
- Pancreatic function and diabetes
- Liver Disease Diagnosis and Treatment
- Growth Hormone and Insulin-like Growth Factors
- Adrenal and Paraganglionic Tumors
- Chronic Kidney Disease and Diabetes
- Renal Diseases and Glomerulopathies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Lipoproteins and Cardiovascular Health
- Chronic Disease Management Strategies
- Ovarian cancer diagnosis and treatment
- Metabolism, Diabetes, and Cancer
- Cardiovascular Function and Risk Factors
- Bioinformatics and Genomic Networks
- Pituitary Gland Disorders and Treatments
- Systemic Lupus Erythematosus Research
- Hormonal and reproductive studies
- Hormonal Regulation and Hypertension
- Cancer, Lipids, and Metabolism
University of Hull
2018-2025
Mackay Base Hospital
2024-2025
James Cook University
2024-2025
Queensland Health
2025
National Health Service
2025
Hull York Medical School
2018-2024
University Teaching Hospital
2021-2023
Newcastle University
2016-2023
University Hospitals of Derby and Burton NHS Foundation Trust
2022
Hull Royal Infirmary
2022
Identification of sequence variants robustly associated with predisposition to diabetic kidney disease (DKD) has the potential provide insights into pathophysiological mechanisms responsible. We conducted a genome-wide association study (GWAS) DKD in type 2 diabetes (T2D) using eight complementary dichotomous and quantitative phenotypes: principal analysis involved 5,717 T2D subjects, 3,345 DKD. Promising signals were evaluated up 26,827 subjects (12,710 DKD). A combined T1D+T2D GWAS was...
OBJECTIVE The FreeStyle Libre (FSL) flash glucose-monitoring device was made available on the U.K. National Health Service (NHS) drug tariff in 2017. This study aims to explore real-world experience of FSL and impact glycemic control, hypoglycemia, diabetes-related distress, hospital admissions. RESEARCH DESIGN AND METHODS Clinicians from 102 NHS hospitals submitted user data, collected during routine clinical care, a secure web-based tool held within N3 network. t Mann-Whitney U tests were...
Circulating levels of soluble receptor for advanced glycation end products (sRAGE) likely comprise both a secreted isoform (esRAGE) and wild-type RAGE cleaved from the cell membrane. Both sRAGE esRAGE have been proposed as biomarkers cardiovascular disease (CVD), but prospective data are limited. We examined relationship to incident coronary heart (CHD) stroke in type 2 diabetic patients followed 3.9 years trial atorvastatin: Collaborative Atorvastatin Diabetes Study (CARDS).We used nested...
What is the predicted risk of acute kidney injury after orthopaedic surgery and does it affect short term long survival?The cohort comprised adults resident in National Health Service Tayside region Scotland who underwent from 1 January 2005 to 31 December 2011. The model was developed 6220 patients (two hospitals) externally validated 4395 a third hospital. Several preoperative variables were selected for candidate predictors, based on literature, clinical expertise, availability setting....
We carried out a genome-wide association study (GWAS) of LDL-c response to statin using data from participants in the Collaborative Atorvastatin Diabetes Study (CARDS; n = 1,156), Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT; 895), and observational phase ASCOT (n 651), all whom were prescribed atorvastatin 10 mg. Following imputation, we combined three studies meta-analysis. found associations that reached significance at rs10455872 (P= 6.13 × 10−9) within LPA gene two single nucleotide...
Metformin is a first-line oral agent used in the treatment of type 2 diabetes, but glycaemic response to this drug highly variable. Understanding genetic contribution metformin might increase possibility personalising treatment. We aimed establish heritability using genome-wide complex trait analysis (GCTA) method.
Diabetes is the leading cause of ESRD. Despite evidence for a substantial heritability diabetic kidney disease, efforts to identify genetic susceptibility variants have had limited success. We extended previous in three dimensions, examining more comprehensive set larger numbers subjects with type 1 diabetes characterized wider range cross-sectional disease phenotypes. In 2843 subjects, we estimated that was 35% (P=6.4×10-3). Genome-wide association analysis and replication 12,540...
Summary Background Empagliflozin is a sodium‐glucose‐cotransporter‐2 inhibitor that improves cardiovascular risk and promotes weight loss in patients with type‐2 diabetes. Polycystic ovary syndrome (PCOS) associated obesity increased risk; therefore, empagliflozin may be of benefit for these women. The aim this study was to compare the effects vs metformin on anthropometric body composition, hormonal metabolic parameters women PCOS. Materials methods A randomized open‐label conducted PCOS...
Polycystic ovary syndrome (PCOS) increases the risk of metabolic and non-alcoholic-fatty-liver disease (NAFLD). Vitamin D supplementation may exert positive effects on liver biochemistry in patients with NAFLD; however, its PCOS are unknown. This randomized, double-blind, placebo-controlled study explored effect vitamin cardiovascular factors (high-sensitivity C-reactive protein (hs-CRP), weight, body mass index (BMI), lipid profile, glucose levels, insulin homeostatic model...
OBJECTIVE This study aimed to explore the relationship between time below range (TBR), impaired awareness of hypoglycemia (IAH), and severe (SH). RESEARCH DESIGN AND METHODS cross-sectional analyzed data from individuals with diabetes using continuous glucose monitors (CGMs) in Association British Clinical Diabetologists audit. Hypoglycemia was assessed via Gold score (≥4 denoting IAH), SH defined as requiring third-party assistance. Logistic regression used determine association TBR...
Purpose Despite a lack of evidence for survival benefit, the American College Obstetrics and Gynecology has recommendations referral to gynecologic oncologists treatment endometrial cancer. Therefore, we propose determine influence on patients with Patients Methods Data were obtained from Medicare Surveillance, Epidemiology, End Results (SEER) databases 1988 2005. Kaplan-Meier Cox proportional hazard methods used analyses. Of 18,338 women, 21.4% received care (group A) while 78.6% treated by...
Neuropathic pain, caused by a lesion or disease affecting the somatosensory system, is one of most common complications in diabetic patients. The purpose this study to identify genetic factors contributing type pain general population.We accessed Genetics Diabetes Audit and Research Tayside (GoDARTS) datasets that contain prescription information monofilament test results for 9439 patients, among which 6927 individuals were genotyped Affymetrix SNP6.0 Illumina OmniExpress chips. Cases...
Osteopontin (SPP1) is an important bone matrix mediator found to have key roles in inflammation and immunity. SPP1 genetic polymorphisms increased osteopontin protein levels been reported be associated with SLE small patient collections. The present study evaluates association between a large cohort of 1141 unrelated patients [707 European-American (EA) 434 African-American (AA)], 2009 controls (1309 EA 700 AA). Population-based case-control analyses were performed. To control for potential...
In conducting genome-wide association studies (GWAS), analytical approaches leveraging biological information may further understanding of the pathophysiology clinical traits. To discover novel associations with estimated glomerular filtration rate (eGFR), a measure kidney function, we developed strategy for integrating prior knowledge into existing GWAS data eGFR from CKDGen Consortium. Our focuses on single nucleotide polymorphism (SNPs) in genes that are connected by functional evidence,...