A5044577316- Chronic Kidney Disease and Diabetes
- Genetic Associations and Epidemiology
- Cardiovascular Function and Risk Factors
- Diabetes Treatment and Management
- Pancreatic function and diabetes
- Diet, Metabolism, and Disease
- Epigenetics and DNA Methylation
- Liver Disease Diagnosis and Treatment
- Diabetes and associated disorders
- Birth, Development, and Health
- Advanced Glycation End Products research
- Hemoglobin structure and function
- Renal Diseases and Glomerulopathies
- Diabetes Management and Research
- Peroxisome Proliferator-Activated Receptors
- Genetic Syndromes and Imprinting
- Lipid metabolism and disorders
- Obesity, Physical Activity, Diet
- Apelin-related biomedical research
- Atherosclerosis and Cardiovascular Diseases
- Erythrocyte Function and Pathophysiology
- Lipoproteins and Cardiovascular Health
- Retinal Diseases and Treatments
- Nutrition, Genetics, and Disease
- Nuclear Receptors and Signaling
Folkhälsans Forskningscentrum
2017-2025
University of Helsinki
2016-2025
Helsinki University Hospital
2016-2025
Helsinki Art Museum
2024
Lund University
2018
Uppsala University
1983-2005
Diabetes is the leading cause of ESRD. Despite evidence for a substantial heritability diabetic kidney disease, efforts to identify genetic susceptibility variants have had limited success. We extended previous in three dimensions, examining more comprehensive set larger numbers subjects with type 1 diabetes characterized wider range cross-sectional disease phenotypes. In 2843 subjects, we estimated that was 35% (P=6.4×10-3). Genome-wide association analysis and replication 12,540...
We evaluated the predictive value and clinical benefit of urinary kidney injury molecule (KIM)-1 for progression diabetic nephropathy (DN) in type 1 diabetes. also investigated its causal role decrease estimated glomerular filtration rate (eGFR) by a Mendelian randomization (MR) approach.We followed 1,573 patients with diabetes 6 years. KIM-1 was measured at baseline normalized creatinine. Cox regression, while added using panel statistical indexes. The causality loss renal function MR,...
Obesity has been posited as an independent risk factor for diabetic kidney disease (DKD), but establishing causality from observational data is problematic. We aimed to test whether obesity causally related DKD using Mendelian randomization, which exploits the random assortment of genes during meiosis. In 6,049 subjects with type 1 diabetes, we used a weighted genetic score (GRS) comprised 32 validated BMI loci instrument relationship macroalbuminuria, end-stage renal (ESRD), or defined...
Background: Peripheral artery disease (PAD) affects >200 million people worldwide and is associated with high mortality morbidity. We sought to identify genomic variants PAD overall in the contexts of diabetes smoking status. Methods: identified genetic then meta-analyzed published summary statistics from Million Veterans Program UK Biobank replicate their findings. Next, we ran stratified genome-wide association analysis ever smokers, never individuals diabetes, no history corresponding...
Abstract Background We aimed to assess whether remnant cholesterol concentration and variability predict the progression of diabetic nephropathy (DN) severe retinopathy (SDR) in type 1 diabetes. Methods This observational prospective study covered 5150 FinnDiane Study participants. Remnant was calculated as total – LDL HDL coefficient variation. DN category based on consensus albuminuria reference limits status confirmed from medical files. SDR defined retinal laser treatment. For 1338...
A subset of individuals with type 1 diabetes mellitus (T1DM) are predisposed to developing diabetic kidney disease (DKD), the most common cause globally end-stage (ESKD). Emerging evidence suggests epigenetic changes in DNA methylation may have a causal role both T1DM and DKD. The aim this exploratory investigation was assess differences blood-derived patterns between T1DM-ESKD long-duration but no upon repeated testing identify potential blood-based biomarkers. Blood-derived from (107...
Variation in DNA methylation (DNAmet) white blood cells and other cells/tissues has been implicated the etiology of progressive diabetic kidney disease (DKD). However, specific mechanisms linking DNAmet variation with risk failure (KF) utility measuring cell personalized medicine are not clear. We measured 277 individuals type 1 diabetes DKD using Illumina EPIC arrays; 51% cohort developed KF during 7 to 20 years follow-up. Our epigenome-wide analysis identified at 17 CpGs...
Twelve-month-old infants' ability to perceive gaze direction in static video images was investigated. The showed a woman who performed attention-directing actions by looking or pointing toward 1 of 4 objects positioned front her (2 on each side). When the model just pointed at objects, she looked straight ahead, and when looked, hands were hidden below tabletop. An eye movement system (TOBII) used register participants. We found that infants clearly discriminated directions objects. There no...
Precise timing of the teratogenic period in diabetic pregnancy is clinical importance since correction glucose intolerance during this may protect offspring from malformations. An experimental approach to elucidate problem with regard skeletal development was made groups pregnant streptozotocin-diabetic rats (MDI), which were treated daily insulin injections except for a 2-day first half pregnancy. The degree metabolic derangement estimated by measurements serum concentrations. During...
Hypertension is one of the strongest risk factors for stroke in general population, while systolic blood pressure has been shown to independently increase type 1 diabetes. The aim this study was elucidate association between different variables and diabetes, explore potential nonlinearity relationship. We included 4105 individuals with diabetes without at baseline, participating nationwide Finnish Diabetic Nephropathy Study. Mean age baseline 37.4 ± 11.9 years, median duration 20.9...
Abstract Context The relationship between body mass index (BMI) and mortality may differ patients with type 1 diabetes the general population; it is not known which clinical characteristics modify relationship. Objective Our aim was to assess BMI interaction clinically meaningful factors. Design, Setting, Participants This prospective study included 5836 individuals from FinnDiane study. Main Outcome Measure Methods We retrieved death data for all participants on 31 December 2015. estimated...
OBJECTIVE Obesity, which is associated with nonalcoholic fatty liver (NAFL), has increased among people type 1 diabetes. Therefore, we explored the associations between body fat distribution and NAFL in this population. RESEARCH DESIGN AND METHODS This study included 121 adults diabetes from Finnish Diabetic Nephropathy (FinnDiane) Study for whom was determined by magnetic resonance imaging. Body composition assessed dual-energy X-ray absorptiometry. Genetic data concerning PNPLA3 rs738409...
Abstract Aims/hypothesis Plasma kallikrein is the central mediator of plasma kallikrein–kinin system, which involved both in vascular control and thrombin formation cascades. The system has also been considered protective pathological conditions, but impact kallikreins on diabetic nephropathy remains unknown. objective this cross-sectional study was to explore association with nephropathy. Methods We measured activity 295 individuals type 1 diabetes at various stages nephropathy, we tested...
Abstract Objectives We studied apolipoprotein C‐III (apoC‐III) in relation to diabetic kidney disease (DKD), cardiovascular outcomes, and mortality type 1 diabetes. Methods The cohort comprised 3966 participants from the prospective observational Finnish Diabetic Nephropathy Study. Progression of DKD was determined medical records. A major adverse cardiac event (MACE) defined as acute myocardial infarction, coronary revascularization, stroke, or through 2017. Cardiovascular data were...
Summary Common genetic variants predispose to obesity with varying contribution by age. We incorporated known into risk scores (GRSs) and investigated their associations overweight/obesity central in preadolescents. Furthermore, we compared GRSs lifestyle factors, tested if they predict the change body size shape a 4‐year follow‐up. utilized 1142 subjects from Finnish Health Teens (Fin‐HIT) cohort. Overweight were defined age‐ gender‐specific mass index (BMI) z ‐score (BMIz), while...
Activation of the receptor for AGE (RAGE) has been shown to be associated with diabetic nephropathy. The soluble isoform RAGE (sRAGE) is considered function as a decoy ligands and thereby protects against complications. A possible association between sRAGE nephropathy still, however, controversial more comprehensive analysis respect in type 1 diabetes therefore warranted. was measured baseline serum samples from 3647 participants nationwide multicentre Finnish Diabetic Nephropathy...
Abstract Background Dyslipidemia is a major risk factor for cardiovascular disease, and diabetes impacts the lipid metabolism through multiple pathways. In addition to standard measurements, apolipoprotein concentrations provide added awareness of burden circulating lipoproteins. While common genetic variants modestly affect serum concentrations, rare mutations can cause monogenic forms hypercholesterolemia other disorders metabolism. We aimed identify low-frequency protein-altering (PAVs)...
Abstract Diet modulates the genetic risk of obesity, but modulation has been rarely studied using scores (GRSs) in children. Our objectives were to identify single nucleotide polymorphisms (SNPs) that drive interaction specific foods with obesity and combine these into GRSs. Genetic food frequency data from Finnish Health Teens study was utilized. In total, 1142 11-year-old subjects genotyped on Metabochip array. BMI-GRS 30 well-known SNPs computed individual items their summary dietary...