Carlo Patrono
A5037962146- Antiplatelet Therapy and Cardiovascular Diseases
- Inflammatory mediators and NSAID effects
- Eicosanoids and Hypertension Pharmacology
- Venous Thromboembolism Diagnosis and Management
- Atrial Fibrillation Management and Outcomes
- Acute Myocardial Infarction Research
- Lipoproteins and Cardiovascular Health
- Diabetes Treatment and Management
- Estrogen and related hormone effects
- Cardiac Imaging and Diagnostics
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Platelet Disorders and Treatments
- Nitric Oxide and Endothelin Effects
- Coronary Interventions and Diagnostics
- Blood Pressure and Hypertension Studies
- Synthesis of β-Lactam Compounds
- Cancer, Lipids, and Metabolism
- Pharmacogenetics and Drug Metabolism
- Hormonal Regulation and Hypertension
- Pharmacology and Obesity Treatment
- Antioxidant Activity and Oxidative Stress
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cardiac Arrhythmias and Treatments
- Systemic Lupus Erythematosus Research
- Heart Failure Treatment and Management
Università Cattolica del Sacro Cuore
2016-2025
University of Chieti-Pescara
2002-2025
Catholic University of America
2000-2025
Agostino Gemelli University Polyclinic
2020-2023
National Agency for New Technologies, Energy and Sustainable Economic Development
2015-2023
Istituti di Ricovero e Cura a Carattere Scientifico
1999-2022
University of Pennsylvania
1997-2021
Sapienza University of Rome
1988-2021
Philadelphia University
2021
Case Western Reserve University
2021
ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation : The Task Force (ACS) European Society Cardiology (ESC).
Coronary artery disease (CAD) is a pathological process characterized by atherosclerotic plaque accumulation in the epicardial arteries, whether obstructive or non-obstructive. This can be modified lifestyle adjustments, pharmacological therapies, and invasive interventions designed to achieve stabilization regression. The have long, stable periods but also become unstable at any time, typically due an acute atherothrombotic event caused rupture erosion. However, chronic, most often...
Kristian Thygesen∗ (Denmark) Joseph S. Alpert∗ (USA) Allan Jaffe (USA) Bernard R. Chaitman (USA) Jeroen J. Bax (The Netherlands) David A. Morrow (USA) Harvey D. White∗ (New Zealand) Hans Mickley (Denmark) Filippo Crea (Italy) Frans Van de Werf (Belgium) Chiara Bucciarelli-Ducci (
with the European Association for Study of Diabetes (EASD).
The use of aspirin for the prevention thrombotic complications in polycythemia vera is controversial.We enrolled 518 patients with vera, no clear indication treatment, and contraindication to such treatment a double-blind, placebo-controlled, randomized trial assess safety efficacy prophylaxis low-dose (100 mg daily). two primary end points were cumulative rate nonfatal myocardial infarction, stroke, or death from cardiovascular causes pulmonary embolism, major venous thrombosis, causes....
Acetylation of platelet cyclooxygenase by oral aspirin is dose dependent and cumulative with repeated administration. However, no single has been found to be completely selective thromboxane (TX) synthesis inhibition in man. We determined the dependence, nature selectivity effects on TXB2 renal prostaglandin (PG) prostacyclin (PGI2) production. measured, radioimmunoassay, serum levels after whole blood clotting urinary excretion PGE2, PGF2α, 6-keto-PGF1α, before or doses given 46 healthy...
Background —Diabetes mellitus (DM) is associated with enhanced lipid peroxidation and persistent platelet activation. We tested the hypothesis that in vivo formation of F 2 -isoprostane 8-iso-prostaglandin (PG)F 2α , a bioactive product arachidonic acid peroxidation, DM contributes to Methods Results —Urine samples were obtained from 85 diabetic patients age- sex-matched healthy subjects for measurement immunoreactive 8-iso-PGF 11-dehydro-thromboxane B (TXM), an index Sixty-two had...
Purpose The clinical course of polycythemia vera is often complicated by thrombosis as well the possible transition to myeloid metaplasia with myelofibrosis or acute leukemia. aim this study was assess rate these complications in subjects receiving currently recommended treatments. Patients and Methods Overall, 1,638 patients from 12 countries were enrolled onto a large, prospective multicenter project aimed at describing history for following outcomes: survival, cumulative cardiovascular...
The ESC Guidelines represent the views of and were produced after careful consideration scientific medical knowledge evidence available at time their publication.The is not responsible in event any contradiction, discrepancy, and/or ambiguity between other official recommendations or guidelines issued by relevant public health authorities, particular relation to good use healthcare therapeutic strategies.Health professionals are encouraged take fully into account when exercising clinical...
It has been suggested that platelet hyperreactivity in patients with diabetes mellitus is associated increased production of thromboxane. We therefore compared the excretion a thromboxane metabolite and function 50 Type II who had normal renal clinical evidence macrovascular disease 32 healthy controls.
ContextObesity, in particular abdominal adiposity, is associated with increased cardiovascular morbidity and mortality through mechanisms possibly linking the metabolic disorder to platelet vascular abnormalities.ObjectiveTo investigate clinical biochemical determinants of lipid peroxidation activation obese women.Design, Setting, ParticipantsCross-sectional comparison, conducted between September 1999 2001, urinary 8-iso prostaglandin F2α (8-iso PGF2α) 11-dehydrothromboxane B2...