This prospective, observational study examines associations between 51 urinary metabolites and risk of progression diabetic nephropathy in individuals with type 1 diabetes by employing an automated NMR metabolomics technique suitable for large-scale urine sample collections.We collected 24-h samples 2670 from the Finnish Diabetic Nephropathy measured metabolite concentrations NMR. Individuals were followed up 9.0 ± 5.0 years until their first sign nephropathy, end-stage kidney disease or...

Abstract We assessed meal timing, frequency, and breakfast consumption habits of adult individuals with type 1 diabetes (n = 1007) taking part in the Finnish Diabetic Nephropathy Study, studied whether they are associated glycaemic control. Data on dietary intake blood glucose measurements were retrieved from food records. HbA 1c was measured at study visit. In whole sample, four peaks energy emerged. Energy greatest evening, followed by midday. Altogether 7% participants reported no between...

Abstract Introduction Type 1 diabetes is suspected to hamper brain growth, implying that people with earlier onset would, on average, achieve lower maximal volume. We set out test this hypothesis. Methods Examining MRI scans of middle-aged type diabetes, we related age at intracranial volume in 180 participants, as well cerebral gray and white matter volumes a subset 113 (63%) using fractional polynomial regression models. Of the 118 (67%) had been diagnosed before 18 years age. Results our...

Abstract Visceral fat is associated with cardiovascular and kidney disease. However, the relationship between body composition anthropometric measures in type 1 diabetes unknown. Using z-statistics, we ranked ability of mass index (BMI), waist circumference (WC), waist-hip ratio (WHR), waist-height (WHtR) a shape (ABSI) to capture from 603 Dual-energy-X-Ray-Absorptiometry scans adults diabetes. Albuminuria was defined as urinary albumin excretion rate at least 30 mg/24 h. Women albuminuria...

Large-scale epidemiological and population data provide opportunities to identify subgroups of people who are at risk disease or exposed adverse environments. Clustering algorithms popular data-driven tools these subgroups; however, relying exclusively on may not produce the best results if dataset does have a clustered structure. For this reason, we propose framework (the R-library Numero) that combines self-organizing map algorithm, permutation analysis for statistical evidence final...

OBJECTIVE Obesity, which is associated with nonalcoholic fatty liver (NAFL), has increased among people type 1 diabetes. Therefore, we explored the associations between body fat distribution and NAFL in this population. RESEARCH DESIGN AND METHODS This study included 121 adults diabetes from Finnish Diabetic Nephropathy (FinnDiane) Study for whom was determined by magnetic resonance imaging. Body composition assessed dual-energy X-ray absorptiometry. Genetic data concerning PNPLA3 rs738409...

Abstract Background Insulin resistance and chronic kidney disease are both associated with increased coronary artery risk. Many formulae estimating glucose disposal rate in type 1 diabetes infer insulin sensitivity from clinical data. We compare associations performance relative to traditional risk factors severity between three the people diabetes. Methods The baseline was estimated by (Williams, Duca, Januszewski) FinnDiane Study participants related subsequent incidence of disease,...

OBJECTIVE To estimate the risk of diabetic nephropathy (DN) progression, incident coronary heart disease (CHD) and stroke, all-cause mortality associated with resistant hypertension (RH) in individuals type 1 diabetes stratified by stages DN, renal function, sex. RESEARCH DESIGN AND METHODS This prospective study included a nationally representative cohort from Finnish Diabetic Nephropathy Study who had purchases antihypertensive drugs at (±6 months) baseline visit (1995–2008). Individuals...

Abstract Introduction Meta-analysis is the cornerstone of robust biomedical evidence. Objectives We investigated whether statistical reporting practices facilitate metabolomics meta-analyses. Methods A literature review 44 studies that used a comparable platform. Results Non-numeric formats were in 31 studies. In half studies, less than third all measures reported. Unadjusted P-values missing from 12 and exact 9 Conclusion Reporting can be improved. recommend (i) publishing results as...

The aim of this study was to evaluate the efficacy rhenium-186 hydroxyethyledine diphosphonate (Re-186 HEDP) for pain relief in patients with disseminated bone metastases primarily from prostate or breast cancer. Up now, 44 taking analgesics were entered and received one more injections 1295 MBq Re-186 HEDP. An analgesic effect than 20%, evaluated by using a verbal rating scale (VRS) visual analogous (VAS), defined as significant could be achieved 60% these patients. Duration clinical...

Objective Vascular endothelial growth factor (VEGF) plays a key role in diabetic retinopathy (DR). Previously, we have reported an association between mutations gene coding for the L-type calcium channel subunit, VEGF and DR. blockers (LTCCBs) been widely used as antihypertensive medication (AHM), but their with DR is still unclear. Therefore, explored effect of LTCCBs compared to other AHMs on concentrations retinal cells human serum. Furthermore, evaluated use risk severe eye disease...

Anemia is a prevalent public health problem associated with nutritional and socio-economic factors that contribute to iron deficiency. To understand the complex interplay of risk factors, we investigated prospective population sample from Jiangsu province in China. At baseline, three-day food intake was measured for 2849 individuals (20 87 years age, mean age 47 ± 14, range 20-87 years, 64% women). five-year follow-up, anemia status re-assessed 1262 individuals. The dataset split age-matched...

OBJECTIVE Individuals with type 1 diabetes are at a high lifetime risk of coronary artery disease (CAD), calling for early interventions. This study explores the use genetic score (GRS) CAD prediction, compares it to established clinical markers, and investigates its performance according age pharmacological treatment. RESEARCH DESIGN AND METHODS in 3,295 individuals from Finnish Diabetic Nephropathy Study (467 incident CAD, 14.8 years follow-up) used three scores: GRS, validated score,...

Type 1 diabetes has been linked to brain volume reductions as well cerebral small vessel disease (cSVD). This study concerns the relationship between normalized volumes (volume fractions) and cSVD, which not examined previously.

Article Bekanntmachung vergütungsbezogener Hauptversammlungsbeschlüsse auf der Internetseite — Kleine Erleichterungen für die Hauptversammlungssaison 2025 was published on October 1, 2024 in the journal Die Aktiengesellschaft (volume 69, issue 20).

Abstract Background Hypertension is a major risk factor of global disease burden, but treatment goals are often not met. A subset individuals with hypertension affected by treatment-resistant (RHTN), and they suffer from increased cardiovascular morbidity mortality. Early identification at RHTN could lead to more efficient antihypertensive drug treatment. Purpose The aim this study was investigate whether polygenic scores (PRS) for systolic (SBP) diastolic blood pressure (DBP) predict in or...

Abstract Background Type 1 diabetes increases the risk of coronary artery disease (CAD). High-throughput metabolomics may be utilized to identify metabolites associated with disease, thus, providing insight into pathophysiology, and serving as predictive markers in clinical practice. Urine is less tightly regulated than blood, therefore, enable earlier discovery disease-associated markers. We studied urine relation incident CAD individuals type diabetes. Methods prospectively 2501 adults...