A5022632123- Retinal Diseases and Treatments
- Nerve injury and regeneration
- Retinal Development and Disorders
- Adipose Tissue and Metabolism
- Nuclear Receptors and Signaling
- Neurogenesis and neuroplasticity mechanisms
- Pancreatitis Pathology and Treatment
- Machine Learning in Bioinformatics
- Tissue Engineering and Regenerative Medicine
- Receptor Mechanisms and Signaling
- Glaucoma and retinal disorders
- RNA Interference and Gene Delivery
- Sirtuins and Resveratrol in Medicine
- Retinal Imaging and Analysis
- Digestive system and related health
- MicroRNA in disease regulation
- Macrophage Migration Inhibitory Factor
- Cancer-related gene regulation
- Parathyroid Disorders and Treatments
- Urological Disorders and Treatments
- Immune Response and Inflammation
- Galectins and Cancer Biology
- Alkaline Phosphatase Research Studies
- Metabolism, Diabetes, and Cancer
- Chronic Obstructive Pulmonary Disease (COPD) Research
Folkhälsans Forskningscentrum
2021-2024
University of Helsinki
2014-2023
Helsinki University Hospital
2017-2023
HiLIFE – Elämäntieteiden Instituutti
2019
Brain-derived neurotrophic factor (BDNF) is a secreted protein of the neurotrophin family that regulates brain development, synaptogenesis, memory and learning, as well development peripheral organs, such angiogenesis in heart postnatal growth repair skeletal muscle. However, while precise regulation BDNF levels an important determinant defining biological outcome, role microRNAs (miRs) modulating expression has not been extensively analyzed. Using silico approaches, reporter systems,...
Degeneration of nigrostriatal dopaminergic system is the principal lesion in Parkinson's disease. Because glial cell line-derived neurotrophic factor (GDNF) promotes survival dopamine neurons vitro and vivo, intracranial delivery GDNF has been attempted for disease treatment but with variable success. For improving GDNF-based therapies, knowledge on physiological role endogenous at sites its expression important. However, due to limitations existing genetic model systems, such scarce. Here,...
Abstract Background Patients with type 1 diabetes have shown an increase in circulating cytokines, altered lipoprotein metabolism and signs of vascular dysfunction response to high‐fat meals. Intestinal alkaline phosphatase ( IAP ) regulates lipid transport inflammatory responses the gastrointestinal tract. We therefore hypothesized that changes activity could profound effects on gut metabolic homeostasis patients diabetes. Methods Faecal samples 41 nondiabetic controls 46 were analysed for...
Abstract Individuals with type 1 diabetes (T1D) carry a markedly increased risk of stroke, distinct clinical and neuroimaging characteristics as compared to those without diabetes. Using whole-exome or whole-genome sequencing 1,051 individuals T1D, we aimed find rare low-frequency genomic variants associated stroke in T1D. We analysed the genome comprehensively single-variant analyses, gene aggregate analyses on windows, enhancers promoters. In addition, attempted replication T1D using...
Mechanisms controlling ureter lenght and the position of kidney are poorly understood. Glial cell-line derived neurotrophic factor (GDNF) induced RET signaling is critical for ureteric bud outgrowth, but function endogenous GDNF in further renal differentiation urogenital system development remains discursive. Here we analyzed mice where 3' untranslated region (UTR) replaced with sequence less responsive to microRNA-mediated regulation, leading increased expression specifically cells...
Diabetic retinopathy is a common diabetes complication that threatens the eyesight and may eventually lead to acquired visual impairment or blindness. While substantial heritability has been reported for proliferative diabetic (PDR), only few genetic risk factors have identified. Using genome-wide sib pair linkage analysis including 361 individuals with type 1 diabetes, we found suggestive evidence of PDR at chromosome 10p12 overlapping CACNB2 gene (logarithm odds = 2.73). Evidence...
Background Translocation of lipopolysaccharide from gram‐negative bacteria into the systemic circulation results in endotoxemia. In addition to acute infections, endotoxemia is detected cardiometabolic disorders, such as cardiovascular diseases and obesity. Methods Results We performed a genome‐wide association study serum activity 11 296 individuals 6 different Finnish cohorts. Endotoxemia was measured by limulus amebocyte lysate assay whole population 2 other techniques (Endolisa...
Objective Vascular endothelial growth factor (VEGF) plays a key role in diabetic retinopathy (DR). Previously, we have reported an association between mutations gene coding for the L-type calcium channel subunit, VEGF and DR. blockers (LTCCBs) been widely used as antihypertensive medication (AHM), but their with DR is still unclear. Therefore, explored effect of LTCCBs compared to other AHMs on concentrations retinal cells human serum. Furthermore, evaluated use risk severe eye disease...
Abstract Brain-derived neurotrophic factor (BDNF) regulates multiple biological processes ranging from central nervous system development and function to neuroinflammation myogenic differentiation repair. While coordination of BDNF levels is in determining the outcome, mechanisms involved controlling are not fully understood. Here we find that both short (BDNF-S) long (BDNF-L) 3’UTR isoforms contain conserved adenylate- uridylate rich elements (AREs) may serve as binding sites for...
Abstract Objective : Vascular endothelial growth factor (VEGF) plays a key role in diabetic retinopathy (DR). L-type calcium channel blockers (LTCCBs) have been widely used as antihypertensive medication (AHM), but their association with VEGF and DR is still unclear. Therefore, we explored the effect of LTCCBs compared to other AHMs on concentrations retinal cells human serum. Furthermore, evaluated between use risk severe eye disease (SDED). Research design methods Müller (MIO-M1) were...
Abstract Aims Individuals with type 1 diabetes (T1D) carry a markedly increased risk of stroke, distinct clinical and neuroimaging characteristics as compared to those without diabetes. Using whole-genome sequencing (WGS) whole-exome (WES), we aimed find rare low-frequency genomic variants associated stroke in T1D. The lead findings were followed up various datasets replicate the assess their specificity Methods Results We studied genetics 1,051 individuals T1D using WGS or WES. analysed...
Abstract Objective Vascular endothelial growth factor (VEGF) plays a key role in diabetic retinopathy (DR). L-type calcium channel blockers (LTCCBs) have been widely used as antihypertensive medication (AHM), but their association with VEGF and DR is still unclear. Therefore, we explored the effect of LTCCBs compared to other AHMs on concentrations retinal cells human serum. Furthermore, evaluated between use risk severe eye disease (SDED). Research design methods Müller (MIO-M1) were...