A5071127270- Diabetes Treatment and Management
- Diabetes Management and Research
- Metabolism, Diabetes, and Cancer
- Retinal Imaging and Analysis
- Retinal Diseases and Treatments
- Diabetes and associated disorders
- Bariatric Surgery and Outcomes
- Diet and metabolism studies
- Diabetes Management and Education
- Pancreatic function and diabetes
- Clinical Nutrition and Gastroenterology
- COVID-19 Clinical Research Studies
- Pharmacology and Obesity Treatment
- Cardiovascular Function and Risk Factors
- Retinal and Optic Conditions
- Glaucoma and retinal disorders
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Pancreatitis Pathology and Treatment
- Peroxisome Proliferator-Activated Receptors
- Neuroendocrine Tumor Research Advances
- Botulinum Toxin and Related Neurological Disorders
- Lung Cancer Treatments and Mutations
- Liver Disease Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
Sandwell & West Birmingham Hospitals NHS Trust
2016-2025
Birmingham City Hospital
2016-2025
National Health Service
2017-2023
University Hospitals Birmingham NHS Foundation Trust
2022
Sandwell College
2020
University of Glasgow
2019
The Christie Hospital
1995-2018
The Christie NHS Foundation Trust
2014-2018
University of Birmingham
2018
Manchester Academic Health Science Centre
2014-2017
Reliable and efficient optic disk localization segmentation are important tasks in automated retinal screening. General-purpose edge detection algorithms often fail to segment the due fuzzy boundaries, inconsistent image contrast or missing features. This paper presents an algorithm for of nerve head boundary low-resolution images (about 20 /spl mu//pixel). Optic is achieved using specialized template matching, by a deformable contour model. The latter uses global elliptical model local with...
OBJECTIVE The FreeStyle Libre (FSL) flash glucose-monitoring device was made available on the U.K. National Health Service (NHS) drug tariff in 2017. This study aims to explore real-world experience of FSL and impact glycemic control, hypoglycemia, diabetes-related distress, hospital admissions. RESEARCH DESIGN AND METHODS Clinicians from 102 NHS hospitals submitted user data, collected during routine clinical care, a secure web-based tool held within N3 network. t Mann-Whitney U tests were...
Changes in retinal vessel diameter are an important sign of diseases such as hypertension, arteriosclerosis and diabetes mellitus. Obtaining precise measurements vascular widths is a critical demanding process automated image analysis the typical only few pixels wide. This paper presents algorithm to measure subpixel accuracy. The measurement based on two-dimensional difference Gaussian model, which optimized fit intensity segment. performance method evaluated against Brinchmann-Hansen's...
Because acute myocardial infarction may affect plasma lipid concentrations it is commonly recommended that assessment of these should be delayed until about three months after the event. A study was therefore conducted fasting in 58 patients with infarction. Measurements were made during their stay hospital (days 1, 2, and 9) later. Triglyceride remained unchanged throughout. Values total cholesterol, low density lipoprotein, high lipoprotein all fell significantly between first two days day...
Hyperglycemia is the major risk factor for microvascular complications in patients with type 2 diabetes (T2D). However, cardiovascular disease (CVD) principal cause of death, and lowering HbA1c has only a modest effect on reducing CVD mortality. The recently published LEADER SUSTAIN-6 trials demonstrate that, T2D high risk, glucagon-like peptide 1 receptor agonists liraglutide semaglutide reduce primary adverse cardiac events (MACE) end point (cardiovascular nonfatal myocardial infarction,...
We explored longitudinal changes associated with switching to hybrid closed-loop (HCL) insulin delivery systems in adults type 1 diabetes and elevated HbA1c levels despite the use of intermittently scanned continuous glucose monitoring (isCGM) pump therapy.We undertook a pragmatic, preplanned observational study participants included National Health Service England pilot. Adults using isCGM across 31 centers an ≥8.5% who were willing commence HCL therapy included. Outcomes change HbA1c,...
OBJECTIVE This study aimed to explore the relationship between time below range (TBR), impaired awareness of hypoglycemia (IAH), and severe (SH). RESEARCH DESIGN AND METHODS cross-sectional analyzed data from individuals with diabetes using continuous glucose monitors (CGMs) in Association British Clinical Diabetologists audit. Hypoglycemia was assessed via Gold score (≥4 denoting IAH), SH defined as requiring third-party assistance. Logistic regression used determine association TBR...
5-amino salicylic acid coated with acrylic based resin was given orally to eight patients active ulcerative colitis. Abdominal X-rays confirmed that the preparation released its contents in terminal ileum and proximal colon. Differences between individuals were marked; plasma 'concentration-time profile' reflected variations time taken for tablets reach ileum.
To assess the extent, safety, efficacy and tolerability of reported off-licence exenatide use through a nationwide audit.The Association British Clinical Diabetologists hosted password-protected, online collection anonymized data in real clinical practice. Three hundred fifteen contributors from 126 centres across UK provided on 6717 patients. HbA1c weight changes, discontinuation, adverse events treatment satisfaction were compared between non-insulin insulin-treated patients.Four thousand...
OBJECTIVE--To examine the traditional view that unawareness of hypoglycaemia and inadequate hypoglycaemic counterregulation in insulin dependent diabetes mellitus are manifestations autonomic neuropathy. DESIGN--Perspective assessment detailed neuropathy patients with according to adequacy their counterregulation. SETTING--One routine diabetic unit a university teaching hospital. PATIENTS--23 Patients aged 21-52 (seven symptoms suggesting neuropathy, nine serious clinical problem...
To investigate the effect of age and diabetes on corneal sensitivity using noncontact aesthesiometer (NCCA).One hundred sixteen nondiabetic subjects 111 diabetic (33 type I 78 II) were recruited divided into three groups: Young (<or=29 years), Middle (30-59 years) Older (>or=60 years). The exclusion criteria included patients with severe retinopathy requiring treatment, a history invasive ocular surgery, or conditions known to affect sensitivity. cooling sensation threshold, for right eye...
During 20-22 September Manchester is to host the 1993 follow up last year's "earth summit" in Rio de Janeiro. At that summit threat posed by world overpopulation received considerable attention. Catholicism was perceived as opposed birth control and therefore a particular threat. This based on notion only method of approved church--natural family planning--is unreliable, unacceptable, ineffective. In 20 years since E L Billings colleagues first described cervical mucus symptoms associated...
Glycosylated hemoglobin (HbA1) is widely used as an index of glycemic control in diabetic patients. However, due to the long survival time erythrocytes (120 days), it remains elevated for several weeks after improved control. Other plasma proteins are similarly glycosylated, and glycosylated serum albumin (GSA) has a shorter half-life (20 should detect changes earlier. Fasting blood glucose (FBG), GSA, HbA1 were measured weekly newly diagnosed patients (N = 12) 8 wk beginning treatment....
PURPOSE To compare standard and intensive treatment strategies for patients with high-grade non-Hodgkin's lymphoma (NHL) of poor prognosis, defined by the international prognostic index. PATIENTS AND METHODS Thirty-four received chemotherapy 11 weeks doxorubicin, cyclophosphamide, vincristine, bleomycin, etoposide, prednisolone, methotrexate (VAPEC-B), 33 7 VAPEC-B, three cycles ifosfamide/cytarabine, then high-dose busulfan/cyclophosphamide followed autologous blood progenitor-cell (BPC)...
Two retinal cameras (Canon CR2 45NM and CR3 45NM) have recently become available are capable of producing an instant colour photography a 45 degree field retina, including the macula optic disc, without dilatation pupils being necessary. The ability each camera to detect diabetic retinopathy was compared with that doctors in clinics using ophthalmoscopy during busy clinic hours. found be considerably superior terms quality photograph because it can use smaller pupil. Overall, detection rate...
Our aim was to compare the efficacy of Therabite® jaw motion rehabilitation system (Atos Medical) with that wooden spatulas relieve and prevent trismus in patients who have had radiotherapy for stage three four oral oropharyngeal cancer. Secondary aims were assess feasibility impact exercise on health-related quality life (QoL), use health services after treatment. We designed a randomised, open-label, controlled, three-centre study effectiveness cost spatulas. studied compliance exercises...
To determine the association between prescription of SGLT2 inhibitors (SGLT2is) and diabetic ketoacidosis (DKA) incidence or mortality in people with type 2 diabetes (T2D) hospitalized COVID-19.