A5010089797- Vitamin D Research Studies
- Diabetes Management and Research
- Hormonal Regulation and Hypertension
- Adrenal and Paraganglionic Tumors
- Diabetes Treatment and Management
- Diabetes and associated disorders
- Pancreatic function and diabetes
- Chronic Kidney Disease and Diabetes
- Mesenchymal stem cell research
- Vitamin C and Antioxidants Research
- Climate Change and Health Impacts
- Tissue Engineering and Regenerative Medicine
- Blood Pressure and Hypertension Studies
- Adrenal Hormones and Disorders
- Parathyroid Disorders and Treatments
- Pituitary Gland Disorders and Treatments
- Chronic Disease Management Strategies
- Dialysis and Renal Disease Management
- Vitamin K Research Studies
- Gestational Diabetes Research and Management
- Bone health and osteoporosis research
- Chemokine receptors and signaling
- COVID-19 Clinical Research Studies
- Vasculitis and related conditions
- Clinical Laboratory Practices and Quality Control
University Hospital Galway
2014-2025
Ollscoil na Gaillimhe – University of Galway
2015-2025
Saolta University Health Care Group
2016-2024
University Hospital Limerick
2023
University of Leicester
2023
Leicester General Hospital
2023
NIHR Leicester Biomedical Research Centre
2023
University of Limerick
2023
University Hospitals of Leicester NHS Trust
2023
Regenerative Medicine Institute
2021
We explored longitudinal changes associated with switching to hybrid closed-loop (HCL) insulin delivery systems in adults type 1 diabetes and elevated HbA1c levels despite the use of intermittently scanned continuous glucose monitoring (isCGM) pump therapy.We undertook a pragmatic, preplanned observational study participants included National Health Service England pilot. Adults using isCGM across 31 centers an ≥8.5% who were willing commence HCL therapy included. Outcomes change HbA1c,...
Significance Statement Mesenchymal stromal cells (MSCs) may offer a novel therapy for diabetic kidney disease (DKD), although clinical translation of this approach has been limited. The authors present findings from the first, lowest dose cohort 16 adults with type 2 diabetes and progressive DKD participating in randomized, placebo-controlled, dose-escalation phase 1b/2a trial next-generation bone marrow–derived, anti-CD362 antibody–selected allogeneic MSCs (ORBCEL-M). A single intravenous...
Over 70% of patients with advanced breast cancer will develop bone metastases for which there is no cure. Mesenchymal Stem Cells (MSCs) and their derivative osteoblasts are subpopulations cells within the marrow environment, postulated as potential interacting targets disseminating because ability to secrete a range chemokines. This study aimed investigate chemokine secretion throughout MSC differentiation into effect on cells. Primary MSCs osteoblast progenitors were cultured in appropriate...
This best practice guide is written with the aim of providing an overview current hybrid closed-loop (HCL) systems in use within United Kingdom's (UK) National Health Service (NHS) and to provide education advice for their management on both individual clinical service level. The environment diabetes technology, particularly HCL systems, rapidly evolving. past decade has seen unprecedented advances development systems. These improve glycaemic outcomes reduce burden treatment people type 1...
CKD is accompanied by abnormal inflammation, which contributes to progressive loss of functional renal tissue and accelerated cardiovascular disease. Although studies have documented that dysregulation monocyte maturation function associated with its complications, it not well characterized. This study reveals a distinctive human subtype high propensity for releasing proinflammatory mediators activating endothelial cells increased in adults compared risk normal kidney function. It also...
Transient hypocalcemia is a well-recognized occurrence after total thyroidectomy. It has been hypothesized that underlying vitamin D deficiency may increase the risk of this complication, although to date there are few data in literature supporting hypothesis.To investigate whether perioperative levels have any effect on postthyroidectomy hypocalcemia.We performed retrospective review prospectively maintained database thyroidectomies from November 1, 2009, through September 30, 2012, at an...
Activin A, an inflammatory mediator implicated in cellular senescence-induced adipose tissue dysfunction and profibrotic kidney injury, may become a new target for the treatment of diabetic disease (DKD) chronic diseases. We tested hypothesis that human DKD-related injury leads to upregulation activin A blood urine cell model. further hypothesized circulating parallels markers DKD.In two adult diabetes cohorts controls (Minnesota, USA; Galway, Ireland), relationships between plasma (or...
Abstract There is a large body of literature demonstrating social gradient in health and increasing evidence an association between deprivation diabetes complications. Diabetic kidney disease (DKD) increases mortality people with diabetes. Socioeconomic increasingly recognized as modifier risk factors for but also independent factor itself disease. This may not be truly appreciated by clinicians warrants further attention exploration. In this review we explore the to date from Europe on...
ABSTRACT Background Experience‐Based Co‐Design (EBCD) is a popular collaborative process where service users and healthcare providers share their experiences of using delivering services to identify ways adapt enhance those experiences. Objective This study aimed enablers barriers the successful implementation EBCD as part Ireland's recently adopted Enhanced Community Care (ECC) programme. Design Service staff at two sites ( N = 17) participated in an accelerated designed provision for older...
Chronic limb threatening ischemia (CLTI) is the most severe form of peripheral vascular disease which can lead to amputation with a high associated mortality rate. Endothelial colony forming cells (ECFCs) show potential as cell therapy revascularize limbs individuals CLTI. However, autologous ECFCs from patient blood (PB) have been reported dysfunctional phenotype. We investigated this phenotype in CLTI, and without diabetes mellitus (DM), determine ECFC suitability an therapy. PB-ECFCs were...
Abstract Recent studies suggest a possible association between dephosphorylated-uncarboxylated MGP (dp-ucMGP) and glomerular filtration rate (GFR). This study aimed to establish normative data in an adult Caucasian population explore the potential utility of dp-ucMGP patients with diabetes mellitus (DM) without diabetic kidney disease (DKD). Healthy volunteers (HVs) (cross-sectional study) participants DM (prospective cohort were recruited. Plasma was measured using IDS®-iSYS Ina Ktif assay....
Chronic kidney disease (CKD) affects 11-13% of the world's population and greatly increases risk cardiovascular (ASCVD) death. It is characterized by systemic inflammation disturbances in blood leukocytes that remain incompletely understood. In particular, abnormalities numbers relative proportions three major monocyte subsets - classical, intermediate non-classical – are described CKD end-stage renal disease. this study, we absolute leukocyte subtypes adults with function varying from...
Abstract Background Approximately 1 billion people worldwide have Vitamin D deficiency. The aim of this study was to compare status and serum 25-hydroxyvitamin (25(OH)D) concentrations among adults sampled in the community, outpatient clinics, as hospital inpatients nursing homes West Ireland. secondary determine associations between length stay (inpatients) at time 25(OH)D sampling status. Methods A cross-sectional carried out. Patients who had analysis out Galway University Hospitals...
Up to 70% of patients with ANCA-associated vasculitis (AAV) develop GN, 26% progressing ESKD. Diagnostic-grade and noninvasive tools detect active renal inflammation are needed. Urinary soluble CD163 (usCD163) is a promising biomarker vasculitis, but diagnostic-grade assay, assessment its utility in prospective diagnosis flares, evaluation proteinuric states needed.We assessed usCD163 assay (1) real-world cohort 405 AAV 121 healthy 488 non-AAV disease controls; (2) multicenter study 84...
Background The Endocrine Society Clinical Practice Guideline on Phaeochomocytoma and Paraganglioma recommends phlebotomy for plasma-free metanephrines with patients fasted supine using appropriately defined reference intervals. Studies have shown higher diagnostic sensitivities these criteria. Further, seated-sampling protocols, result interpretation, intervals that do not compromise sensitivity should be employed. Objective To determine the impact performance financial cost of...
Introduction This study aimed to determine the prevalence of diabetic kidney disease (DKD) and rapid renal function decline identify indices associated with this among adults attending a diabetes center in Northern Europe. Research design methods is retrospective cohort 4606 patients who attended Ireland between June 2012 December 2016. Definition/staging chronic used Kidney Disease: Improving Global Outcomes (KDIGO) classification based on data from most recently appointment. Relevant...
The purpose of this study was to assess the clinical performance and user acceptance capillary blood samples prepared remotely using MiniCollect® collection device as an alternative by venepuncture for glycated haemoglobin (HbA1c ) analysis.Following written informed consent, a cross-sectional conducted in individuals aged ≥18 years with any type diabetes who routinely self-monitor their glucose. Eligible participants recruited whilst attending routine appointments were required provide...
Abstract Background: Growth differentiation factor-15 (GDF-15), a stress responsive cytokine, is promising biomarker of renal functional decline in diabetic kidney disease (DKD). This study aimed primarily to establish normative data and secondarily evaluate the potential utility GDF-15 DKD using Roche Diagnostics electrochemiluminescence immunoassay (ECLIA) an Irish Caucasian population. Methods: Following informed consent, 188 healthy volunteers 128 participants with diabetes (72 56...