A5056187330- Vasculitis and related conditions
- Renal Diseases and Glomerulopathies
- Complement system in diseases
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Hemoglobinopathies and Related Disorders
- COVID-19 and healthcare impacts
- Otitis Media and Relapsing Polychondritis
- Pregnancy and preeclampsia studies
- Urticaria and Related Conditions
- Systemic Lupus Erythematosus Research
- Cell Adhesion Molecules Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- COVID-19 Clinical Research Studies
- Inflammatory Bowel Disease
- Muscle and Compartmental Disorders
- Abdominal vascular conditions and treatments
- Health Systems, Economic Evaluations, Quality of Life
- Autoimmune Bullous Skin Diseases
- Dialysis and Renal Disease Management
- Acute Myeloid Leukemia Research
- Restraint-Related Deaths
- Liver Diseases and Immunity
- Xenotransplantation and immune response
- Traumatic Ocular and Foreign Body Injuries
Cork University Hospital
2011-2025
University College Cork
2016-2025
Trinity College Dublin
2017-2024
Sechenov University
2023
Trinity Health
2023
Queen's University
2020-2022
Kidney Centre
2016-2021
South Infirmary Victoria University Hospital
2020-2021
Tallaght University Hospital
2018-2019
University Health Network
2018-2019
Background and objectives: Mild hyponatremia has traditionally been considered benign, but it may be associated with gait attention deficits an increased risk of falls that result in fracture. A retrospective study was conducted to quantify the association fracture occurrence examine whether this relationship is independent osteoporosis. Design, setting, participants, & measurements: This analyzed 1408 consecutive female patients who underwent bone mineral density measurement (Lunar IDXA)...
Significance Statement Clonal hematopoiesis of indeterminate potential (CHIP), a premalignant expansion clonal leukocytes caused by acquired somatic mutations in myeloid stem/progenitor cells, occurs 10%–15% the general population aged 65 years or older. This proinflammatory condition appears causally associated with cardiovascular disease and death. The authors found that 43 172 (25%) individuals advanced CKD had CHIP. Those CHIP 2.2-fold greater risk kidney failure over 5 follow-up were...
A specific biomarker that can separate active renal vasculitis from other causes of dysfunction is lacking, with a kidney biopsy often being required. Soluble CD163 (sCD163), shed by monocytes and macrophages, has been reported as potential in diseases associated excessive macrophage activation. Thus, we hypothesized urinary sCD163 crescent macrophages correlates glomerular inflammation. We detected rat urine early the disease course experimental vasculitis. Moreover, microdissected...
ABSTRACT The histopathological lesions, minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS) are entities without immune complex deposits which can cause podocyte injury, thus frequently grouped under the umbrella of podocytopathies. Whether MCD FSGS may represent a spectrum same remains matter conjecture. Both require repeated high-dose glucocorticoid therapy with alternative immunosuppressive treatments reserved for relapsing or resistant cases response rates...
Glucocorticoids (GCs) are a mainstay of treatment for patients with ANCA-associated vasculitis (AAV) but associated significant adverse effects. Effective remission induction in severe AAV using extremely limited GC exposure has not been attempted. We tested an early rapid withdrawal regimen AAV. Patients active MPO- or PR3-ANCA ANCA-negative pauci-immune glomerulonephritis were included. Induction consisted two doses rituximab, 3 months low-dose CYC and short course oral (for between 1 2...
<b><i>Background:</i></b> The prevalence of kidney disease (KD) due to inherited genetic conditions in Ireland is unknown. aim this study was characterise an adult population and identify familial clusters within the population. <b><i>Methods:</i></b> This a multicenter cross-sectional patients with Republic Ireland, from January 2014 September 2014, recruiting dialysis units out-patient renal departments. A survey performed by collecting data...
Abstract Background Prior work has shown that urinary soluble CD163 (usCD163) displays excellent biomarker characteristics for detection of active renal vasculitis using samples included new diagnoses with highly disease. This study focused on the use usCD163 in more clinically relevant state mild flare and compared results testing directly to monocyte chemoattractant protein-1 (uMCP-1). Methods Patients anti-neutrophil cytoplasmic antibody (ANCA)-associated (AAV, n = 88) were identified...
Abstract A definition of “disease modification“ for kidney disease is long overdue. Here, we propose three key criteria modification in immune-mediated glomerulonephritis and podocytopathies: minimizing activity, preventing loss structure function, reducing treatment-related toxicity. To be considered a DMAND, drug must fulfil all hence, the DMAND status may not clear at time regulatory approval. Notably, aspect CKD diseases treated separately, e.g., RASi but immune itself. Defining DMANDs...
To investigate the occurrence of venous thromboembolic events (VTE) in a large cohort patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) across European Union, Turkey, Russia, UK and North America.Patients definite diagnosis AAV who were followed for at least 3 months had sufficient documentation included. Data on VTE, including either deep vein thrombosis or pulmonary embolism, collected retrospectively from tertiary centres. Univariate multivariate...
Early detection of renal involvement in anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) is major clinical importance to allow prompt initiation treatment and limit damage. Urinary soluble cluster differentiation 163 (usCD163) has recently been identified as a potential biomarker for active vasculitis. However, significant number patients with test negative using usCD163. We therefore studied whether CD25 (sCD25), T cell activation marker, could improve the flares...
Up to 70% of patients with ANCA-associated vasculitis (AAV) develop GN, 26% progressing ESKD. Diagnostic-grade and noninvasive tools detect active renal inflammation are needed. Urinary soluble CD163 (usCD163) is a promising biomarker vasculitis, but diagnostic-grade assay, assessment its utility in prospective diagnosis flares, evaluation proteinuric states needed.We assessed usCD163 assay (1) real-world cohort 405 AAV 121 healthy 488 non-AAV disease controls; (2) multicenter study 84...
To collate best practice recommendations on the management of patients receiving in-center hemodialysis during COVID-19 pandemic, based published reports and current public health advice, while considering ethical principles unique circumstances Canadian units across country.The workgroup members used Internet search engines to retrieve documents from provincial local programs; agencies; Centers for Disease Control Prevention; webinars slides other kidney nonreviewed preprints. PubMed was...
Atypical hemolytic uremic syndrome (aHUS) is a complement-mediated thrombotic microangiopathy (TMA), caused by uncontrolled activation of the alternative complement pathway in setting autoantibodies to or rare pathogenic genetic variants proteins. Pregnancy may serve as trigger and unmask aHUS/complement-mediated TMA [aHUS/CM-TMA] which has severe, life-threatening consequences. It can be difficult diagnose aHUS/CM-TMA pregnancy due overlapping clinical features with other syndromes...
Innate lymphocyte populations, such as innate lymphoid cells (ILCs), γδ T cells, invariant natural killer (iNK T) and mucosal-associated (MAIT) are emerging important effectors of immunity involved in various inflammatory autoimmune diseases. The aim this study was to assess the frequencies absolute numbers lymphocytes well conventional monocytes peripheral blood from a cohort anti-neutrophil cytoplasm autoantibody (ANCA)-associated vasculitis (AAV) patients. Thirty-eight AAV patients 24...
Purpose of program: To provide guidance on the management patients with advanced chronic kidney disease (CKD) not requiring replacement therapy during COVID-19 pandemic. Sources information: Program-specific documents, pre-existing, and related to COVID-19; documents from national international agencies; webinars, including webinars that we hosted for input feedback; additional information formal informal review published academic literature. Methods: Challenges in care CKD pandemic were...
This paper will provide guidance on how to best manage patients with end-stage kidney disease who be or are being treated home dialysis during the COVID-19 pandemic.Program-specific documents, pre-existing, and related COVID-19; documents from national international agencies; webinars, including webinars that we hosted for input feedback; additional information formal informal review of published academic literature.Members Canadian Society Nephrology (CSN) Board Directors solicited a team...