A5029209345- Parathyroid Disorders and Treatments
- Immune Cell Function and Interaction
- Hematopoietic Stem Cell Transplantation
- CAR-T cell therapy research
- Trace Elements in Health
- Immunotherapy and Immune Responses
- Inflammasome and immune disorders
- Immune Response and Inflammation
- Dialysis and Renal Disease Management
- Vitamin D Research Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Cell death mechanisms and regulation
- Medical Imaging and Pathology Studies
- Childhood Cancer Survivors' Quality of Life
- Lymphatic System and Diseases
- Phagocytosis and Immune Regulation
- Blood Pressure and Hypertension Studies
- NF-κB Signaling Pathways
- Cancer, Hypoxia, and Metabolism
- Radiation Dose and Imaging
- Immune cells in cancer
- Aluminum toxicity and tolerance in plants and animals
- Bone health and treatments
- T-cell and B-cell Immunology
- Heavy Metal Exposure and Toxicity
Fred Hutch Cancer Center
2018-2025
St Thomas' Hospital
2024
Cancer Research Center
2019-2023
Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa
2018-2023
Royal College of Surgeons in Ireland
2014-2020
Cork University Hospital
2007-2016
Beaumont Hospital
2016
National Cancer Registry
2016
University College Cork
2015
University Hospital Galway
2011-2013
Background and objectives: Mild hyponatremia has traditionally been considered benign, but it may be associated with gait attention deficits an increased risk of falls that result in fracture. A retrospective study was conducted to quantify the association fracture occurrence examine whether this relationship is independent osteoporosis. Design, setting, participants, & measurements: This analyzed 1408 consecutive female patients who underwent bone mineral density measurement (Lunar IDXA)...
BMP4 produced by endothelial cells promotes thymic regeneration after acute damage activating FOXN1 and its downstream targets.
Background Athletic groin pain remains a common field-based team sports time-loss injury. There are few reports of non-surgically managed cohorts with athletic pain. Aim To describe clinical presentation/examination, MRI findings and patient-reported outcome (PRO) scores for an cohort. Methods All patients had history including demographics, injury duration, sport played standardised examination. underwent PRO score to assess recovery. A diagnosis the injured anatomical structure was made...
Designing effective antileukemic immunotherapy will require understanding mechanisms underlying tumor control or resistance. Here, we report a mechanism of escape from immunologic targeting in an acute myeloid leukemia (AML) patient, who relapsed 1 year after with engineered T cells expressing human leukocyte antigen A*02 (HLA-A2)–restricted cell receptor (TCR) specific for Wilms’ epitope, WT1 126–134 (T TCR-C4 ). Resistance occurred despite persistence functional therapeutic and continuous...
Prolonged lymphopenia represents a major clinical problem after cytoreductive therapies such as chemotherapy and the conditioning required for hematopoietic stem cell transplant (HCT), contributing to risk of infections malignant relapse. Restoration T-cell immunity depends on tissue regeneration in thymus, primary site development, although capacity thymus repair itself diminishes over its lifespan. However, boosting thymic function reconstitution is considerable importance, there are...
Abstract The success of T cell therapies in solid tumors is limited by the immunosuppressive tumor microenvironment (TME). secretion metabolites TME directs immune landscape, acting as signaling molecules regulating responses and reducing efficacy therapies. Succinate, a mitochondrial metabolite, accumulates secreted into interstitial space TME. Mutations succinate processing gene, dehydrogenase (Sdh), occur range tumors, leading to further accumulation secretion. Studies revealed that...
<title>Abstract</title> Adoptive therapies using T cells genetically modified with cell receptors (TCR)s have shown limited efficacy in the solid tumor setting. Although functional CD4<sup>+</sup> and CD8<sup>+</sup> transduced a TCR specific for HLA-A2-restricted melanoma-associated antigen A1 (MAGE-A1, T<sub>TCR−MA1−CD8αβ</sub>) could be detected post-transfer were safe one patient who subsequently progressed, T<sub>TCR−MA1−CD8αβ</sub> insufficient to sustain antitumor activity “stress”...
Abstract Introduction Experience with the use of patient‐reported outcome measures such as EQ‐5D and symptom module Palliative care Outcome Scale—Renal Version (POS‐S Renal) mortality prediction tools in hemodialysis is limited. Methods A prospective survival study people receiving (N = 362). The POS‐S Renal were used to assess burden self‐rated health (with a component). Participants followed from instrument completion death or end. Competing risks analysis was evaluate associations time...
Mutations in the superoxide dismutase 1 ( SOD1 ) gene contribute to motoneuron degeneration and are evident 20% of familial amyotrophic lateral sclerosis cases. Mutant induces microglial activation through a stimulation Toll-like receptors 2 4 (TLR2 TLR4). In present study, we identified proapoptotic Bcl-2 family protein Bid as positive regulator mutant -induced TLR-nuclear factor-κB (NF-κB) signaling microglia. bid -deficient primary mouse microglia showed reduced NF-κB response TLR4 or...
Colorectal cancer is a molecularly heterogeneous disease. Responses to genotoxic chemotherapy in the adjuvant or palliative setting vary greatly between patients, and colorectal cells often resist by evading apoptosis. Antagonists of an inhibitor apoptosis proteins (IAPs) can restore defective signaling degrading cIAP1 cIAP2 inhibition XIAP. Due multiple molecular mechanisms-of-action these targets, responses IAP antagonist may differ distinct colon cells. In this study, Birinapant...
To compare automated interactive screening using the ThinPrep Imaging System with independent manual primary of 12,000 routine slides.With first 6,000 cases, Review Scopes (RS) results from 22 fields view (FOV) only were compared to screening. In next any abnormality detected in FOV resulted full on cytotechnologist's own microscope. Sensitivity and specificity together their 95% CIs calculatedfor each method.In set 6, 000 diagnostic sensitivity imager 85.19% 96.67%, respectively. The 89.38%...
<i>Background:</i> Chronic kidney disease (CKD) is associated with increased risk of fragility fracture but whether this independent osteoporosis unclear. <i>Methods:</i> We conducted a retrospective cross-sectional study 1,702 female patients referred for dual-energy X-ray absorptiometry (DXA) scanning (Lunar IDXA) between September 2006 and April 2007. Estimated glomerular filtration rate (eGFR; ml/min/1.73 m<sup>2</sup>) by Modification Diet in Renal...
Chronic pro-inflammatory signaling propagates damage to neural tissue and affects the rate of disease progression. Increased activation Toll-like receptors (TLRs), master regulators innate immune response, is implicated in etiology several neuropathologies including amyotrophic lateral sclerosis, Alzheimer's disease, Parkinson's disease. Previously, we identified that Bcl-2 family protein BH3-interacting domain death agonist (Bid) potentiates TLR4-NF-κB response glia, specifically...
Despite limitations of routine methods, Clinical Practice Guidelines support the assessment bone mineral density (BMD) and vascular calcification in renal transplant recipients. Changes fat mass also occur post-transplantation, although they are traditionally difficult to measure accurately. We report feasibility, convenience accuracy measuring above 3 parameters using a novel CT protocol. conducted cross-sectional study 64 first allograft recipients (eGFR > 30 ml/min/1.73 m2). Quantitative...
<i>Background:</i> The relationship between calcium intake and serum level in hemodialysis patients is poorly understood. <i>Methods:</i> We quantify total oral using detailed 7-day food diaries with 294 patient days of observation 42 stable, non-diabetic subjects. <i>Results:</i> Mean (SD) albumin-corrected was 9.84 mg/dl (0.8). low (<8.4 mg/dl) 2 patients, low-normal (8.4–9.49) 9 high-normal (9.5–10.2) 18 high (>10.2) 13 patients. (diet plus...
Background The optimal approach to monitoring blood pressure (BP) in the peritoneal dialysis (PD) population is unclear. Ambulatory BP reliably predicts prognosis, but can be inconvenient. accuracy of home this unproven. automated BpTRU device (BpTRU Medical Devices, Coquitlam, BC, Canada), which provides an average up 6 successive in-office measurements, has not been studied patient group. Methods We 17 patients (average age: 54 ± 12 years; men, 5 women; 94% on PD) attending a single...
Posttransplant lymphoproliferative disorders (PTLD) are a common malignancy after renal transplantation with high incidence of PTLD described in the first posttransplant year. We sought to determine and risk determinants Irish kidney transplant recipients.Retrospective observational study 1996 adult recipients between 1991 2010 Republic Ireland. Recipients were cross-referenced National Cancer Registry PTLD. Kaplan-Meier analysis was performed for PTLD-free survival, allograft patient...
Interleukin-18 is an acute phase pro-inflammatory molecule crucial for mediating viral clearance by activating Th1 CD4+, cytotoxic CD8+ T, and NK cells. Here, we show that mature IL-18 generated in the thymus following numerous distinct forms of tissue damage, all which cause caspase-1-mediated immunogenic cell death. We report stimulated cells limit endogenous thymic regeneration, a critical process ensures restoration immune competence after insults like stress, infection, chemotherapy,...
Objectives The automated BpTRU device has been shown to improve the accuracy of in-office blood pressure assessment in hypertensive populations. We aimed determine whether this was also true for patients with chronic kidney disease. Materials and methods recorded 80 outpatients disease by usual measurement measurement. established there were any statistically significant differences absolute values measured either method these had impact on control. Results Systolic diastolic pressures...
The axon initial segment (AIS) is a neuronal compartment defined by ankyrin-G expression. We here demonstrate that the IKK-complex co-localizes and interacts with cytoskeletal anchor protein in immunoprecipitation proximity-ligation experiments cortical neurons. Overexpression of 270 kDa variant suppressed, while gene-silencing expression increased nuclear factor-κB (NF-κB) activity primary neurons, suggesting sequesters transcription factor AIS. also found p65 bound to ank3 (ankyrin-G)...