A5036484323- Dialysis and Renal Disease Management
- Central Venous Catheters and Hemodialysis
- Blood Pressure and Hypertension Studies
- Muscle and Compartmental Disorders
- Acute Kidney Injury Research
- Parathyroid Disorders and Treatments
- Cardiovascular Syncope and Autonomic Disorders
- Renal Diseases and Glomerulopathies
- Healthcare cost, quality, practices
- Pharmacological Effects and Toxicity Studies
- Kidney Stones and Urolithiasis Treatments
- Heart Failure Treatment and Management
- Hemodynamic Monitoring and Therapy
- Chronic Kidney Disease and Diabetes
- COVID-19 and healthcare impacts
- Renal and Vascular Pathologies
- Hormonal Regulation and Hypertension
- Erythropoietin and Anemia Treatment
- Sodium Intake and Health
- Heart Rate Variability and Autonomic Control
- Magnesium in Health and Disease
- Cardiovascular Health and Disease Prevention
- Renal function and acid-base balance
- Potassium and Related Disorders
- Clostridium difficile and Clostridium perfringens research
University of Ottawa
2015-2024
Ottawa Hospital
2014-2023
Ottawa Hospital Research Institute
2012-2023
Ontario Stroke Network
2021
University Health Network
2004-2017
McMaster University
2017
Institute for Clinical Evaluative Sciences
2017
Royal Devon and Exeter Hospital
2016
Deerfield (United States)
2010
Kidney Research UK
2008-2010
This study investigated the association of intra-abdominal adhesions with risk peritoneal dialysis (PD) catheter complications. Individuals undergoing laparoscopic PD insertion were prospectively enrolled from eight centers in Canada and United States. Patients grouped based on presence observed during insertion. The primary outcome was composite never starting, termination PD, or need for an invasive procedure caused by flow restriction abdominal pain. Seven hundred fifty-eight individuals...
The long-term effect of policies restricting contact between residents and pharmaceutical company representatives (PCRs) during internal medicine training is unknown. McMaster University Department Medicine in Hamilton, Ontario, implemented a policy PCR with trainees 1992, whereas the at Toronto, has no such policy.To determine if presence restrictive frequency PCRs predict attitudes behavior several years after completion training.Retrospective analysis 3 cohorts physicians: Toronto...
Division of Nephrology,1 University Western Ontario, London, Ontario; Nephrology,2 Toronto, Nephrology,3 McMaster University, Hamilton, Nephrology and Transplant Immunology,4 Alberta, Edmonton, Alberta; Nephrology,5 Dalhousie Halifax, Nova Scotia; Nephrology,6 Ottawa, Nephrology,7 British Columbia, Vancouver, Canada
Noninfectious complications of peritoneal dialysis (PD) are increasing in relative importance due to success decreasing the rate PD peritonitis. Mechanical catheter emerging as an important cause technique failure at same time experience with is declining North America. There also interest metabolic and glucose-sparing strategies reduce risk for hyperglycemia, hyperinsulinemia, hyperleptinemia. This clinical commentary focuses on these noninfectious PD.
Coronary artery calcification (CAC) is highly prevalent among dialysis patients and associated with increased cardiovascular all cause mortality. Magnesium (Mg) inhibits vascular in animal in-vitro studies but whether the same effect occurs humans uncertain. A single centre cross-sectional study of 80 peritoneal (PD) patients; on PD only for a minimum 3 months. radiologist blinded to patient status calculated their abdominal aortic (AAC) scores lateral lumbar spine radiographs, validated...
Summary We report three deaths following percutaneous dilatational tracheostomy in a series of 1187 procedures undertaken single intensive care unit over 13‐year period. All were due to severe haemorrhage. The first patient died during the procedure from uncontrollable haemorrhage innominate vein. Delayed other two patients was caused by tube eroding into aorta one and vein other. In both these patients, tracheal stoma found at postmortem be sited unexpectedly low. Fatal is rare complication...
The likelihood of peritoneal dialysis (PD) utilization following a PD catheter insertion attempt is poorly described. We explored the risk factors for nonuse, focusing on method implantation. This population-based retrospective cohort study employed Ontario administrative health data to identify 3886 predialysis adults who had an incident implantation between 2002 and 2010. impact including open-surgical (open, n = 1884), surgical-laparoscopic (laparoscopic, 1154), nephrology-percutaneous...
Alpha-blockers (ABs) are commonly prescribed as part of a multidrug regimen in the management hypertension. We set out to assess risk hypotension and related adverse events with AB use compared other blood pressure (BP) lowering drugs using population-based, retrospective cohort study women (≥66 years) between 1995 2015 Ontario, Canada. Cox proportional hazards examined association (syncope, fall, fracture) BP matched via high dimensional propensity score. The primary outcome was composite...
Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) are widely used in clinical practice. The safety efficacy of these agents peritoneal dialysis (PD) patients unclear.We conducted a systematic review to study the ACEI ARB use PD patients. Primary outcome measures were mortality cardiovascular (CV) events; secondary renal function, proteinuria, hyperkalemia, erythropoietin requirement at 3 months.We searched Medline, EMBASE, Cochrane Central Register...
Our centre uses a modification of the Moncrief technique embedding peritoneal dialysis (PD) catheters. We undertook this study to test hypothesis that catheter survival on PD is function time left embedded prior use.Data were retrospectively abstracted from review patient records those who received first over 5-year period. Patients divided into tertiles based number days between insertion and exteriorization create three equal groups representing early (group 1, 11-47 days), mid 2, 48-133...
Mechanical failure of the peritoneal dialysis (PD) catheter is an important cause technique failure. Fluoroscopic guidewire manipulation may be undertaken in attempt to correct The purpose this study was determine efficacy fluoroscopic previously embedded PD catheters, factors associated with successful manipulation, and complication rate manipulation.A single-center, retrospective review 70 consecutive patients undergoing for mechanical their from June 2006 February 2011 undertaken....
to nurse practitioners and physician assistants, prescribing decisions may involve pharmacists; registered nurses who supervise treatment of chronic disease, implement standing orders, educate patients about new therapies; procedural arrange visits from medical device representatives oversee purchasing.In Australia, Karanges et al found that many nonphysicians received speaking fees, highlighting their influential role. 3 The expansion the Sunshine Act in United States include additional...
<h3>Abstract</h3> Cohesin and CCCTC-binding factor (CTCF) are key regulatory proteins of three-dimensional (3D) genome organization. extrudes DNA loops that anchored by CTCF in a polar orientation. Here, we present direct evidence binding polarity controls cohesin-mediated looping. Using single-molecule imaging CTCF-cohesin collisions, demonstrate critical N-terminal motif blocks cohesin translocation The cryo-electron microscopy structure the intact cohesin-CTCF complex reveals this ahead...
To collate best practice recommendations on the management of patients receiving in-center hemodialysis during COVID-19 pandemic, based published reports and current public health advice, while considering ethical principles unique circumstances Canadian units across country.The workgroup members used Internet search engines to retrieve documents from provincial local programs; agencies; Centers for Disease Control Prevention; webinars slides other kidney nonreviewed preprints. PubMed was...
Background: Peritoneal dialysis (PD) is a more cost-effective therapy to treat kidney failure than in-center hemodialysis, but successful requires functioning PD catheter that causes minimal complications. In 2015, the North American Chapter of International Society for Dialysis established Catheter Registry improve practices and patient outcomes following insertion. Aims: The objective this study propose methodology defining insertion-related complications lead significant adverse events...
Introduction The integrated home dialysis model has been proposed as an optimal of care for patients with ESRD (1). It involves the initiation peritoneal (PD) followed by a timely switch to hemodialysis (HD) if kidney transplant is not available. Globally, use PD first advocated number groups cost-minimization strategy (2). To date, there are limited published data examining actual implementation (3–5). largest study comes from Australia and New Zealand Dialysis Transplant Registry (3)....