A5053123152- Dialysis and Renal Disease Management
- Central Venous Catheters and Hemodialysis
- Health Systems, Economic Evaluations, Quality of Life
- Chronic Kidney Disease and Diabetes
- Potassium and Related Disorders
- Acute Kidney Injury Research
- Blood Pressure and Hypertension Studies
- Healthcare cost, quality, practices
- Heart Failure Treatment and Management
- Hemodynamic Monitoring and Therapy
- Diabetes Treatment and Management
- Renal and Vascular Pathologies
- Renal Diseases and Glomerulopathies
- Muscle and Compartmental Disorders
- Healthcare Policy and Management
- Pediatric Urology and Nephrology Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Chronic Disease Management Strategies
- Palliative Care and End-of-Life Issues
- IoT and Edge/Fog Computing
- Cardiovascular Function and Risk Factors
- Mobile Health and mHealth Applications
- Genomics and Rare Diseases
- Medical Coding and Health Information
- Hospital Admissions and Outcomes
Western University
2016-2025
London Health Sciences Centre
2016-2025
Western University of Health Sciences
2024
Lawson Health Research Institute
2023
Institute for Clinical Evaluative Sciences
2012-2021
University of Toronto
2012-2021
Mount Sinai Hospital
2021
Lunenfeld-Tanenbaum Research Institute
2021
Royal North Shore Hospital
2019
Women's College Hospital
2018
Although there is a perception that the use of peritoneal dialysis declining worldwide, compilations global data are unavailable to test this hypothesis. We assessed longitudinal trends in from 1997 2008 130 countries. The preferred sources were renal registries, followed by nephrology societies, health ministries, academic centers, national experts, and industry affiliates. In 2008, approximately 196,000 patients representing 11% population. total, 59% treated developing countries 41%...
Acute kidney injury is a serious complication of elective major surgery. dialysis used to support life in the most severe cases. We examined whether rates and outcomes acute after surgery have changed over time. data from Ontario's universal health care databases study all consecutive patients who had at 118 hospitals between 1995 2009. Our primary were within 14 days surgery, death 90 chronic for did not recover function. A total 552,672 underwent during period, 2231 whom received dialysis....
Statins abrogate ischemic renal injury in animal studies but whether they are renoprotective humans is unknown. We conducted a population-based retrospective cohort study that included 213,347 older patients who underwent major elective surgery the province of Ontario, Canada from 1995 to 2008. During first 14 postoperative days, 1.9% (4020 patients), developed acute kidney and 0.5% (1173 required dialysis. The 30-day mortality rate was 2.8% (5974 patients). Prior surgery, 32% were taking...
♦Many patients start renal replacement therapy urgently on in-center hemodialysis via a central venous catheter, which is considered suboptimal. An alternative approach to manage these them peritoneal dialysis (PD). In this report, we describe the first reported Canadian experience with an urgent-start PD program. Additionally reviewed literature in area. ♦In prospective observational study, report our single academic center. This program started July 2010. We included who initiated...
Background Nirmatrelvir/ritonavir was approved for use in high-risk outpatients with coronavirus disease 2019 (COVID-19). However, patients severe CKD were excluded from the phase 3 trial, and drug is not recommended those GFR <30 ml/min per 1.73 m 2 . On basis of available pharmacological data, we developed a modified low-dose regimen nirmatrelvir/ritonavir 300/100 mg on day 1, followed by 150/100 daily to 5. In this study, report our experience dose dialysis Canadian province Ontario....
This study investigated the association of intra-abdominal adhesions with risk peritoneal dialysis (PD) catheter complications. Individuals undergoing laparoscopic PD insertion were prospectively enrolled from eight centers in Canada and United States. Patients grouped based on presence observed during insertion. The primary outcome was composite never starting, termination PD, or need for an invasive procedure caused by flow restriction abdominal pain. Seven hundred fifty-eight individuals...
In the last 15 years in Canada, there have been less stringent guidelines for peritoneal dialysis (PD) adequacy, availability of novel PD solutions, and lower PD-related peritonitis rates. Effects these changes on outcomes incident patients treated with during this period are unknown.Risk technique failure mortality were compared among three cohorts who initiated following periods: 1995-2000, 2001-2005, 2006-2009. A multivariable model was used to evaluate time using inverse probability...
Remote patient management (RPM) offers renal health care providers and patients with end-stage kidney disease opportunities to embrace home dialysis therapies greater confidence the potential obtain better clinical outcomes. Barriers evidence required increase adoption of RPM by nephrology community need be clearly defined. Ten from specialties including nephrology, cardiology, pediatrics, epidemiology, nursing, informatics experience in use systems gathered Vienna, Austria discuss for,...
Background and objectives Assisted peritoneal dialysis is a treatment option for individuals with barriers to self-care who wish receive home dialysis, but previous research suggests that this modality associated higher rate of hospitalization. The objective our study was determine whether assisted has different hospital days compared in-center hemodialysis. Design, setting, participants, & measurements We conducted multicenter, retrospective cohort by linking quality assurance dataset...
Rapid kidney function decline (RKFD) predicts cardiovascular morbidity and mortality, but serial assessment of estimated GFR (eGFR) is not cost-effective for the general population. Here, we evaluated predictive value albuminuria three thresholds dipstick proteinuria to identify RKFD in 2,574 participants a community-based prospective cohort study with median 7 years follow-up. Median change eGFR was -0.78 ml/min per 1.73 m(2) year; 8.5% experiencing RKFD, defined as >5% annual from...
OBJECTIVES: Bowel preparations are commonly prescribed drugs. Case reports and our clinical experience suggest that sodium picosulfate bowel can precipitate severe hyponatremia in some older adults. At present, this risk is poorly quantified. We investigated the association between use of METHODS: conducted a population-based retrospective cohort study using six linked administrative databases Ontario, Canada. All Ontario residents over age 65 years who filled an outpatient preparation...
Objectives Evaluate the validity of International Classification Diseases, 10th revision (ICD-10) code for hyperkalaemia (E87.5) in two settings: at presentation to an emergency department and hospital admission. Design Population-based validation study. Setting 12 hospitals Southwestern Ontario, Canada, from 2003 2010. Participants Elderly patients with serum potassium values (n=64 579) admission 497). Primary outcome Sensitivity, specificity, positive-predictive value negative-predictive...
<h3>Background:</h3> The antibiotic nitrofurantoin is commonly used to treat uncomplicated urinary tract infections. However, when this drug by patients with reduced kidney function, its urine concentration may be subtherapeutic. <h3>Methods:</h3> We conducted a population-based study of older women (mean age 79 years) in Ontario, Canada, whose estimated glomerular filtration rate was relatively low (median 38 mL/min per 1.73 m<sup>2</sup>) and for whom 1 4 antibiotics had been prescribed...
Introduction: Statistical methods to assess the impact of an intervention are increasingly used in clinical research settings. However, a comprehensive review geared toward practitioners is not yet available. Methods and Materials: We provide three intervention: difference-in-differences (DID), segmented regression interrupted time series (ITS), interventional autoregressive integrated moving average (ARIMA). also compare methods, illustration their use through important healthcare-related...
Background: Genetic causes of chronic diseases, once considered rare in adult-onset disease, now account for between 10 and 20% cases kidney disease (CKD). Confirming a genetic diagnosis can influence management; however, the utility testing older adults remains poorly understood, partly due to age-based restrictions on access. To better evaluate diagnostic yield clinical this population, we analyzed data from aged ≥50 years with CKD who were assessed specialized genetics clinic. Methods: We...