A5089130962- Chronic Kidney Disease and Diabetes
- Dialysis and Renal Disease Management
- Acute Kidney Injury Research
- Blood Pressure and Hypertension Studies
- Renal Transplantation Outcomes and Treatments
- Renal and Vascular Pathologies
- Sodium Intake and Health
- Renal Diseases and Glomerulopathies
- Pregnancy and preeclampsia studies
- Central Venous Catheters and Hemodialysis
- Healthcare Policy and Management
- Healthcare cost, quality, practices
- Primary Care and Health Outcomes
- Pediatric Urology and Nephrology Studies
- Chronic Disease Management Strategies
- Genetic and Kidney Cyst Diseases
- Renal function and acid-base balance
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiovascular Health and Disease Prevention
- Clinical practice guidelines implementation
- Diabetes Treatment and Management
- Potassium and Related Disorders
- Heart Failure Treatment and Management
- Pregnancy and Medication Impact
- Cardiac, Anesthesia and Surgical Outcomes
University of Ottawa
2016-2025
Ottawa Hospital
2016-2025
Ottawa Hospital Research Institute
2015-2025
Lawson Health Research Institute
2023
Health Sciences Centre
2023
University of Toronto
2023
Sunnybrook Health Science Centre
2023
Hamilton Health Sciences
2023
Western University
2023
Kidney Foundation of Canada
2006-2021
Serum creatinine is the most commonly used screening test for renal failure. We hypothesized that serum would underestimate degree of failure in elderly people because they have a reduced muscle mass. If so, this lead to underrecognition and thus suboptimal care patients with severe failure.We conducted retrospective medical record review all 65 years or older an outpatient academic family medicine practice. The glomerular filtration rate was calculated using Cockcroft Gault formula evaluate...
Because of the limitations serum creatinine as a marker glomerular filtration rate (GFR) in children, we assessed diagnostic accuracy novel beta-trace protein (BTP) comparison with cystatin C (Cys-C), beta(2)-microglobulin (beta(2)-MG), and conventional indicators reduced GFR.We obtained samples from 225 children (age range, 0.2-18 years) various renal pathologies who were referred for nuclear medicine clearance investigations (technetium-diethylenetriamine pentaacetic acid or...
Accurate measurement of GFR is critical for the evaluation new therapies and care renal transplant recipients. Although not accurate in transplantation, often estimated using creatinine-based equations. Cystatin C a marker that seems to be more than creatinine. Equations predict based on serum cystatin concentration have been developed, but their accuracy transplantation unknown. was four equations (Filler, Le Bricon, Larsson, Hoek) are seven creatinine 117 adult measured radiolabeled...
Background: Serum creatinine concentration is an inadequate screening test for chronic kidney disease, especially in elderly patients.We hypothesized that laboratory reporting of estimated glomerular filtration rate (GFR) accompanied with educational intervention would improve recognition disease (CKD).Methods: We conducted a before-and-after study at outpatient family medicine practice.Patients 65 years or older whom Cockcroft-Gault GFR could be calculated from their medical record were...
The new Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation was developed to address the systematic underestimation of glomerular filtration rate (GFR) by Modification Diet in Renal (MDRD) Study patients with a relatively well-preserved kidney function. performance for transplant recipients (KTRs) is unknown.We used plasma clearance (99m)Tc-diethylenetriamine pentaacetic acid measure GFR cohort 207 stable KTRs and estimated CKD-EPI equation.The mean bias -4.5 mL x min(-1)...
Abstract Objective To study age specific associations of modest reductions in estimated glomerular filtration rate (eGFR) with adverse outcomes. Design Retrospective, population based cohort study. Setting Linked healthcare administrative datasets Ontario, Canada. Participants Adult residents (18-65 years) at least one outpatient eGFR value (categorized 10 unit increments from 50 mL/min/1.73m 2 to >120 ), no history kidney disease. Main outcome measures eGFRs and hazard ratios composite...
Practice facilitation has been associated with meaningful improvements in disease prevention and quality of patient care. Using practice facilitation, the Improved Delivery Cardiovascular Care (IDOCC) project aimed to improve delivery evidence-based cardiovascular care primary practices across a large health region. Our goal was evaluate IDOCC's impact on adherence processes delivery. A pragmatic stepped wedge cluster randomized trial recruiting providers located Eastern Ontario, Canada...
Significance Statement Pregnancies in women with CKD carry greater risk than pregnancies the general population. The small number of prior studies has limited estimates this risk, especially among those advanced CKD. We report results a population-based cohort study Ontario, Canada, that assessed more 500,000 pregnancies, including 600 baseline eGFR < 60 ml/min per 1.73 m 2 . investigation demonstrates increases different adverse maternal and fetal outcomes lower further elevation...
Background: Patients with end-stage kidney disease (ESKD) have high rates of gastrointestinal bleeding due to several risk factors including platelet dysfunction, comorbid illness, and use antiplatelet medications. Proton pump inhibitors (PPIs) reduce are recommended for high-risk patients such as those prescribed dual therapy (DAPT). Whether inappropriate duration DAPT and/or lack appropriate PPI contribute the known elevated in hemodialysis is not known. Objectives: To determine whether...