A5056937094- Acute Kidney Injury Research
- Dialysis and Renal Disease Management
- Atrial Fibrillation Management and Outcomes
- Chronic Kidney Disease and Diabetes
- Venous Thromboembolism Diagnosis and Management
- Potassium and Related Disorders
- Pregnancy and preeclampsia studies
- Health Systems, Economic Evaluations, Quality of Life
- Blood Pressure and Hypertension Studies
- Heart Failure Treatment and Management
- Pregnancy and Medication Impact
- Cardiac Arrest and Resuscitation
- Renal function and acid-base balance
- Cardiac Arrhythmias and Treatments
- Healthcare cost, quality, practices
- Acute Ischemic Stroke Management
- Central Venous Catheters and Hemodialysis
- Muscle and Compartmental Disorders
- Maternal and fetal healthcare
- Emergency and Acute Care Studies
- Bipolar Disorder and Treatment
- Renal Diseases and Glomerulopathies
- Diabetes Treatment and Management
- Sepsis Diagnosis and Treatment
- Healthcare Policy and Management
St. Michael's Hospital
2016-2025
University of Toronto
2016-2025
Institute for Clinical Evaluative Sciences
2014-2023
Western University
2016-2023
Sunnybrook Health Science Centre
2020-2023
Hamilton Health Sciences
2023
Lawson Health Research Institute
2023
Health Sciences Centre
2020-2023
Li Ka Shing Foundation
2018-2021
Ottawa Hospital
2021
Among critically ill patients with acute kidney injury, the impact of renal replacement therapy modality on long-term function is unknown. Compared conventional intermittent hemodialysis, continuous may promote recovery by conferring greater hemodynamic stability; yet not enhance patient survival and resource intense. Our objective was to determine whether associated a lower risk chronic dialysis as compared among survivors injury.Retrospective cohort study.Linked population-wide...
To achieve sustainable change, quality improvement initiatives must become the new way of working rather than something added on to routine clinical care. However, most organizational change is not maintained. In this next article in Moving Points Nephrology feature improvement, we provide health care professionals with strategies sustain and support improvement. Threats sustainability may be identified both at beginning a project when it ready for implementation. The National Health Service...
Large, population-based administrative healthcare databases can be used to identify patients with chronic kidney disease (CKD) when serum creatinine laboratory results are unavailable. We examined the validity of algorithms that combined hospital encounter and physician claims database codes for detection CKD in Ontario, Canada.We accrued 123,499 over age 65 from 2007 2010. All had a baseline value estimate glomerular filtration rate (eGFR). developed an algorithm search presence CKD....
New staging systems for CKD account both reduced eGFR and albuminuria; whether each measure associates with greater risk of hemorrhage is unclear. In this retrospective cohort study (2002–2010), we grouped 516,197 adults ≥40 years old by (≥90, 60 to <90, 45 <60, 30 <45, 15 <30, or <15 ml/min per 1.73 m 2 ) urine albumin-to-creatinine ratio (ACR; >300, 30–300, <30 mg/g) examine incidence hemorrhage. The 3-year cumulative increased 20-fold across declining increasing ACR...
Quality improvement involves a combined effort among health care staff and stakeholders to diagnose treat problems in the system. However, professionals often lack training quality methods, which makes it challenging participate efforts. This article familiarizes with how begin project. The initial steps involve forming an team that possesses expertise of problem, leadership, change management. Stakeholder mapping analysis are useful tools at this stage, these reviewed help identify...
Sodium polystyrene sulfonate is commonly prescribed for the treatment of hyperkalemia. Case reports intestinal injury after administration sodium with sorbitol resulted in a US Food and Drug Administration warning discontinuation combined 70% sorbitol-sodium formulations. There are ongoing concerns about gastrointestinal (GI) safety use.To assess risk hospitalization adverse GI events associated use patients advanced age.Population-based, retrospective matched cohort study eligible adults...
Mortality after AKI is high, but the causes of death are not well described. To better understand in patients a hospitalization with and to determine patient hospital factors associated mortality, we conducted population-based study residents Ontario, Canada, who survived from 2003 2013. Using linked administrative databases, categorized cause year discharge as cardiovascular, cancer, infection-related, or other. We calculated standardized mortality ratios compare survivors those general...
Serum Creatinine Levels Before, During, and After PregnancyEstimating renal function before during pregnancy has clinical importance: kidney dysfunction can affect maternal perinatal health.Glomerular hyperfiltration is a typical physiological adaptation to pregnancy, reflected by decrease in levels of serum creatinine (SCr) with advancing gestational age.Creatinine-based equations used estimate glomerular filtration may misclassify 1 as they depend on steady state balance.Moreover, 24-hour...
Background and objectives Survivors of AKI are at higher risk CKD death, but few patients see a nephrologist after hospital discharge. Our during this 2-year vanguard phase trial were to determine the feasibility randomizing survivors early follow-up with or usual care, collect data on care processes outcomes. Design, setting, participants, & measurements We performed randomized controlled in hospitalized Kidney Disease Improving Global Outcomes (KDIGO) stage 2–3 four hospitals Toronto,...
Clinical outcomes after a hospital discharge are poorly defined for patients receiving maintenance in-center (outpatient) hemodialysis. To describe the proportion and characteristics of these who rehospitalized, visit an emergency department, or die within 30 days from acute hospitalization, we conducted population-based study all adult hemodialysis were discharged between January 1, 2003, December 31, 2011, 157 care hospitals in Ontario, Canada. For with more than one randomly selected...
Regulatory agencies warn about the risk of acute kidney injury (AKI) after initiation sodium-glucose cotransporter-2 (SGLT2) inhibitors. Our objective was to quantify 90-day AKI in older adults SGLT2 inhibitors routine clinical practice. We conducted a population-based retrospective cohort study Ontario, Canada, involving with diabetes who were aged 66 years or and newly dispensed either an inhibitor dipeptidyl peptidase-4 (DPP4) outpatient setting between 2015 2017. used inverse probability...