A5046117154- Renal Transplantation Outcomes and Treatments
- Organ Donation and Transplantation
- Liver Disease and Transplantation
- Renal Diseases and Glomerulopathies
- Genomics and Rare Diseases
- Organ Transplantation Techniques and Outcomes
- Dermatological and Skeletal Disorders
- Poisoning and overdose treatments
- Transplantation: Methods and Outcomes
- Drug-Induced Hepatotoxicity and Protection
- Renal and related cancers
- Hepatitis C virus research
- Parathyroid Disorders and Treatments
- Hypertrophic osteoarthropathy and related conditions
- Biomedical Ethics and Regulation
Western University
2021-2025
London Health Sciences Centre
2024-2025
Background: Genetic causes of chronic diseases, once considered rare in adult-onset disease, now account for between 10 and 20% cases kidney disease (CKD). Confirming a genetic diagnosis can influence management; however, the utility testing older adults remains poorly understood, partly due to age-based restrictions on access. To better evaluate diagnostic yield clinical this population, we analyzed data from aged ≥50 years with CKD who were assessed specialized genetics clinic. Methods: We...
Vascular calcification is prevalent in chronic kidney disease (CKD). Genetic causes of CKD account for 10-20% adult-onset disease. thought to be one the most important risk factors increased cardiovascular morbidity and mortality patients detectable 80% with end stage (ESKD). Despite high prevalence vascular CKD, no single gene cause has been described. We hypothesized that variants genes may contribute pathogenesis particularly families who exhibit a predominant phenotype. developed list...
Genetic kidney disease (GKD) accounts for 10% to 20% of chronic (CKD). testing using gene panel or targeted exome sequencing (ES) can confirm GKD; however, integration into clinical practice has been hampered by small studies, selective populations, and data predominately derived from research settings. Using prespecified referral criteria a diagnostic pipeline, we performed prospective cohort study describing efficacy utility genetic assessment in patients with CKD. We analyzed 300...
Abstract Background Transplantation offers the best survival for patients with end stage organ disease. Transplant of hepatitis C virus (HCV) nucleic acid test (NAT) positive organs into negative recipients is a novel strategy that can expand donor pool. We aim to evaluate our centre’s experience. Methods preformed retrospective review anti-HCV NAT and transplanted over 27 months. Primary outcome was success rate eradication HCV post-transplant. Secondary outcomes were transmission HCV,...
Massive Acetaminophen (N-acetyl-p-aminophenol; APAP) overdose is a common presentation to emergency departments around the world. While N-acetylcysteine (NAC) remains cornerstone of treatment for APAP overdose, extracorporeal treatment, in form renal replacement therapy with intermittent hemodialysis (IHD) or continuous (CRRT) may provide benefit cases associated altered mental status and metabolic acidosis. One IHD typically sufficient resolution acidosis global improvement clinically. We...
Introduction: All potential kidney transplant recipients undergo rigorous evaluation to rule out or ensure appropriate treatment of conditions that may increase risk post-transplant complications, but specific recommendations regarding workup and candidacy vary across published guidelines. We assessed current pre-transplant practices eligibility criteria for adult transplantation Canada elucidate differences in guideline interpretation identify areas most uncertainty. Methods: compared...