A5059626023- Dialysis and Renal Disease Management
- Parathyroid Disorders and Treatments
- Biochemical effects in animals
- Chronic Kidney Disease and Diabetes
- Electrolyte and hormonal disorders
- Renal and Vascular Pathologies
- Lipoproteins and Cardiovascular Health
- Renal function and acid-base balance
- Bone health and osteoporosis research
- Acute Kidney Injury Research
- Free Radicals and Antioxidants
- Pharmacological Effects and Toxicity Studies
- Renal Diseases and Glomerulopathies
- Vitamin D Research Studies
- Diet, Metabolism, and Disease
- Ion Transport and Channel Regulation
- Bone health and treatments
- Muscle and Compartmental Disorders
- Fibroblast Growth Factor Research
- Central Venous Catheters and Hemodialysis
- Biomedical Research and Pathophysiology
- Erythrocyte Function and Pathophysiology
- Magnesium in Health and Disease
- Metabolism, Diabetes, and Cancer
- Pharmaceutical studies and practices
Heidelberg University
2015-2024
University Hospital Heidelberg
2015-2024
German Center for Pediatric and Adolescent Rheumatology
2010-2024
Heidelberg University
2007-2024
ERKNet
2023
Gazi University
2022
Universitätsklinikum Würzburg
2020
Zentrum für Kinderheilkunde
2017
Temple Street Children's University Hospital
2012
Uniwersytecki Szpital Dziecięcy
2012
Abstract The peritoneum plays an essential role in preventing abdominal frictions and adhesions can be utilized as a dialysis membrane. Its physiological ultrastructure, however, has not yet been studied systematically. 106 standardized peritoneal 69 omental specimens were obtained from 107 patients (0.1–60 years) undergoing surgery for disease affecting the automated quantitative histomorphometry immunohistochemistry. mesothelial cell layer morphology protein expression pattern is similar...
Remote patient management (RPM) offers renal health care providers and patients with end-stage kidney disease opportunities to embrace home dialysis therapies greater confidence the potential obtain better clinical outcomes. Barriers evidence required increase adoption of RPM by nephrology community need be clearly defined. Ten from specialties including nephrology, cardiology, pediatrics, epidemiology, nursing, informatics experience in use systems gathered Vienna, Austria discuss for,...
Histidine-containing dipeptides like carnosine and anserine have protective functions in both health disease. Animal studies suggest that can be metabolized within the kidney. The goal of this study was to obtain evidence metabolism human kidney provide insight with regards diabetic nephropathy. Expression, distribution, localization carnosinase-1 (CNDP1), synthase (CARNS), taurine transporters (TauT) were measured kidneys. CNDP1 CARNS activities vitro. located primarily distal proximal...
<b>BACKGROUND AND PURPOSE:</b> Thromboembolic events are the most common complications of elective coil embolization cerebral aneurysms. Administration oral clopidogrel and/or aspirin could lower thromboembolic complication rate. <b>MATERIALS METHODS:</b> Records over a 10-year period were reviewed in retrospective cohort study. For 369 consecutive procedures, 25 patients received no antiplatelet drugs, 86 drugs only after embolization, and 258 before embolization. <b>RESULTS:</b>...
Background. Molecular Adsorbents Recirculating System (MARS) is an extracorporeal liver support system eliminating albumin-bound and water-soluble substances. While it increasingly applied in patients with acute failure (ALF), no comparison standard dialysis methods has yet been performed. Methods. This analysis of ten children (0.1–18 years) ALF, who underwent a total 22 MARS sessions. Standard adult sets were used seven (23.5–72 kg) Mini three (2.8–13 kg). In eight children, was alternated...
Clinical studies suggested that endothelial dysfunction and damage could be involved in the development severity of acute graft-versus-host disease (aGVHD). Accordingly, we found increased percentage apoptotic Casp3+ blood vessels duodenal colonic mucosa biopsies patients with severe aGVHD. In murine experimental aGVHD, detected microstructural reduced pericyte coverage accompanied by expression tight junction proteins leading to leakage aGVHD target organs. During intestinal vasculature...
Dysregulated calcium homeostasis is common in chronic kidney disease and causally associated with disorders of bone mineralization. However, radiological measures biomarkers do not allow accurate evaluation balance. Non-radioactive isotopes, 42Ca 44Ca, are present our diet sequestered into body compartments following principles kinetic isotope fractionation. Isotopically light preferentially incorporated bone, while heavier 44Ca excreted. The ratio (44/42Caserum) increases when formation...
To investigate the effect of changes in ionized calcium on instantaneous PTH secretion, we examined seven young healthy volunteers by 1-min blood sampling under conditions normo-, hypo-, and hypercalcemia. After a baseline period 75 min, ambient was either increased or decreased 0.2 mmol/L for 105 min clamped infusion gluconate sodium citrate. The characteristics secretion were analyzed deconvolution technique, accounting subject-specific plasma disappearance half-life, as measured during...
Recently, authors have addressed the ability of human basophils to produce IL-4. We report here detection significant serum IL-4 levels in a case acute transformation chronic myelogenous leukemia with predominant basophilic cell population. Leukemic were isolated from patients' PBMC and assayed for their IL-4-mRNA expression secrete this cytokine vitro. cells (> 90% toluidine blue positive) but not other expressed IL-4-mRNA, contained protein, secreted cytokine. These had spontaneous...
Glucose degradation products (GDP) in peritoneal dialysis (PD) solutions are toxic to the membrane and promote formation of advanced glycation end (AGE), which contribute accelerated atherosclerosis amyloidosis. Double chamber PD have a markedly reduced GDP content.We analysed AGE kinetics 21 children (7 months 18 years) on automated prospective multicentre trial with randomized administration single chamber, high-GDP double-chamber, low-GDP solution for 12 weeks each. Total fluorescence,...
Aims and objectives To prevent medication errors in drug handling a paediatric ward. Background One five preventable adverse events hospitalised children is caused by errors. Errors prescription have been studied frequently, but data regarding handling, including preparation administration, are scarce. Design A three‐step intervention study monitoring procedure was used to detect handling. Methods After approval the ethics committee, pharmacists monitored nurses on an 18‐bed ward university...
Double-chamber peritoneal dialysis fluids exert less toxicity by their neutral pH and reduced glucose degradation product content. The role of the buffer compound (lactate bicarbonate) has not been defined in humans.A multicenter randomized controlled trial 37 children on automated was performed. After a 2-month run-in period with conventional fluids, patients were to neutral-pH, low-glucose 35 mM lactate or 34 bicarbonate Clinical biochemical monitoring performed monthly, equilibration...
Understanding and targeting the molecular basis of peritoneal solute protein transport is essential to improve dialysis (PD) efficacy patient outcome. Supplementation PD fluids (PDF) with alanyl-glutamine (AlaGln) increased small reduced loss in a recent clinical trial. Transepithelial resistance 10 kDa 70 dextran were measured primary human endothelial cells (HUVEC) exposed conventional acidic, glucose degradation products (GDP) containing PDF (CPDF) low GDP (LPDF) without AlaGln. Zonula...
Lithium added to peritoneal dialysis fluid protects mesothelial cells and attenuates fibrosis angiogenesis by reducing αB-crystallin.