A5078667064- Hematopoietic Stem Cell Transplantation
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- T-cell and B-cell Immunology
- Mesenchymal stem cell research
- Chemokine receptors and signaling
- Virus-based gene therapy research
- Healthcare Facilities Design and Sustainability
- Lymphatic System and Diseases
- Cell Adhesion Molecules Research
- Bone and Joint Diseases
- Transplantation: Methods and Outcomes
- Iron Metabolism and Disorders
- Acute Myeloid Leukemia Research
- Food Safety and Hygiene
- Hemoglobinopathies and Related Disorders
- Lymphatic Disorders and Treatments
- Immunotherapy and Immune Responses
- Infection Control in Healthcare
- Vascular Malformations and Hemangiomas
- Angiogenesis and VEGF in Cancer
- Dental Research and COVID-19
- Pancreatic function and diabetes
- RNA Interference and Gene Delivery
- Protease and Inhibitor Mechanisms
Charité - Universitätsmedizin Berlin
2016-2025
Humboldt-Universität zu Berlin
2022-2025
Freie Universität Berlin
2022-2025
German Marine Research Consortium
2025
National Center for Tumor Diseases
2025
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2019-2025
Berlin-Brandenburger Centrum für Regenerative Therapien
2019
FH Campus Wien
2014
Abstract Acute myeloid leukemia (AML) is a malignant disorder derived from neoplastic progenitor cells characterized by abnormal proliferation and differentiation. Although novel therapeutics have recently been introduced, AML remains therapeutic challenge with insufficient cure rates. In the last years, immune-directed therapies such as chimeric antigen receptor (CAR)-T were which showed outstanding clinical activity against B-cell malignancies including acute lymphoblastic (ALL). However,...
Abstract Acute myeloid leukemia (AML) still constitutes a dreadful disease with limited therapeutic options. Chimeric antigen receptor (CAR)-modified T cells struggle to target AML partly due lack of true AML-exclusive antigens and heterogeneity the disease. Natural killer (NK) possess high intrinsic killing capacity against might be well suited for treatment this However, generation primary CAR-NK can difficult time consuming. Therefore, robust systems numbers under GMP conditions are...
Background Previous data indicated that the leucine-rich α-2 glycoprotein 1 (LRG1) pathway contributes to vascular dysfunction during cancer growth. Therapeutic targeting of LRG1 normalized tumor vessel and enhanced efficacy anti-cancer adoptive T cell therapy. A major clinical problem after allogeneic hematopoietic stem transplantation (alloHSCT) chimeric antigen receptor (CAR) T-cell therapy is induction hyperinflammatory side effects, which are typically associated with severe endothelial...
Hand hygiene is acknowledged as the single most important measure to prevent nosocomial infections in healthcare setting. Similarly, non-clinical settings, hand recognised a key element helping spread of infectious diseases. The aim this study was evaluate efficacy three different disinfectant sanitizers reducing burden bacterial contamination 60 healthy volunteers community setting, both before and after education about correct use sanitizers. first ease formulations rubs used by general...
Clinical studies suggested that endothelial dysfunction and damage could be involved in the development severity of acute graft-versus-host disease (aGVHD). Accordingly, we found increased percentage apoptotic Casp3+ blood vessels duodenal colonic mucosa biopsies patients with severe aGVHD. In murine experimental aGVHD, detected microstructural reduced pericyte coverage accompanied by expression tight junction proteins leading to leakage aGVHD target organs. During intestinal vasculature...
Angiogenesis and endothelial activation dysfunction have been associated with acute graft-versus-host disease (aGVHD), pointing to the endothelium as a potential target for pharmacological intervention. Defibrotide (DF) is drug an endothelium-protective effect that has approved treatment of veno-occlusive disease/sinusoidal obstruction syndrome after allogeneic hematopoietic cell transplantation. Clinical data suggest DF also reduces incidence aGVHD; however, mechanisms DF-mediated aGVHD...
Despite considerable progress in allogeneic hematopoietic cell transplantation (allo-HCT) has been achieved over the past years, chronic Graft-versus-Host Disease (cGvHD) still contributes to high morbidity rates, thus remaining a major hurdle allo-HCT patients. To understand complex pathophysiology of cGvHD and develop refined prophylaxis treatment strategies, improved pre-clinical models are needed. In this study, we developed two murine models, which display long-term but low mortality...
Microbial products influence immunity after allogeneic hematopoietic stem cell transplantation (allo-SCT). In this context the role of Cathepsin E (Ctse), an aspartate protease known to cleave bacterial peptides for antigen presentation in dendritic cells (DCs), has not been studied. During experimental acute graft-versus-host disease (GVHD), we found infiltration by Ctse positive immune leading higher RNA- and protein levels target organs. deficient allo-SCT recipients, ameliorated GVHD,...
Despite its involvement in various immune functions, including the allogeneic activation of T-lymphocytes, relevance calcium (Ca²+) for GVHD pathobiology is largely unknown. To elucidate a potential association between Ca²+ and GVHD, we analysed Ca²+-sensing G-protein coupled receptor 6a (GPRC6a) signaling preclinical models conducted prospective EBMT study on Ca2+ serum levels prior alloSCT 363 matched sibling peripheral blood stem cell transplantations (alloSCTs). In experimental models,...
The interaction of hematopoietic cells and the bone microenvironment to maintain homeostasis is increasingly appreciated. We hypothesized that transfer allogeneic T lymphocytes has extensive effects on biology investigated trabecular cortical structures, osteoblast reconstitution, vasculature in experimental stem cell transplantations (HSCT). Allogeneic or syngeneic (HSC) were isolated transferred a murine model. After 20, 40, 60 days, structures visualized using microCT histology. Immune...