A5032534022- Sepsis Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Cell death mechanisms and regulation
- Acute Lymphoblastic Leukemia research
- Clusterin in disease pathology
- T-cell and B-cell Immunology
- Hematopoietic Stem Cell Transplantation
- CAR-T cell therapy research
- Immune Cell Function and Interaction
Humboldt-Universität zu Berlin
2024-2025
Charité - Universitätsmedizin Berlin
2024-2025
Freie Universität Berlin
2025
German Marine Research Consortium
2025
National Center for Tumor Diseases
2025
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2025
Alexandria University
2021-2024
Background Previous data indicated that the leucine-rich α-2 glycoprotein 1 (LRG1) pathway contributes to vascular dysfunction during cancer growth. Therapeutic targeting of LRG1 normalized tumor vessel and enhanced efficacy anti-cancer adoptive T cell therapy. A major clinical problem after allogeneic hematopoietic stem transplantation (alloHSCT) chimeric antigen receptor (CAR) T-cell therapy is induction hyperinflammatory side effects, which are typically associated with severe endothelial...
We sought to identify leukemia-associated immunophenotypes (LAIPs) in 50 acute myeloid leukemia (AML) patients at diagnosis using an eight-color multiparameter flow cytometry (MFC) panel and detect if they showed any alteration relapsed/refractory cases.We used the MFC with CD45/side scatter log gating strategy analyze LAIPs AML presenting Alexandria University Hospitals, Egypt relapse refractory cases. Twenty age sex matched bone marrow samples from performing aspirate for non-malignant...