A5049138916- Muscle Physiology and Disorders
- Connective tissue disorders research
- Knee injuries and reconstruction techniques
- Lymphatic System and Diseases
- Neurogenetic and Muscular Disorders Research
- Cancer Cells and Metastasis
- Ubiquitin and proteasome pathways
- Developmental Biology and Gene Regulation
- Cellular Mechanics and Interactions
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Congenital heart defects research
- Wnt/β-catenin signaling in development and cancer
- Genetics and Neurodevelopmental Disorders
- Single-cell and spatial transcriptomics
- Kruppel-like factors research
- RNA modifications and cancer
- Systemic Sclerosis and Related Diseases
- CAR-T cell therapy research
- Mesenchymal stem cell research
- Fibroblast Growth Factor Research
- Genetic Syndromes and Imprinting
- Heterotopic Ossification and Related Conditions
- HER2/EGFR in Cancer Research
- Lymphatic Disorders and Treatments
- TGF-β signaling in diseases
National Center for Tumor Diseases
2025
Freie Universität Berlin
2017-2025
Charité - Universitätsmedizin Berlin
2023-2025
Humboldt-Universität zu Berlin
2023-2025
German Marine Research Consortium
2025
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2025
Max Planck Institute for Molecular Genetics
2013-2016
Fibro-adipogenic progenitors (FAPs) are an interstitial cell population in adult skeletal muscle that support regeneration. During development, connective tissue (MCT) cells proper patterning, however the underlying molecular mechanisms not well understood and it remains unclear whether FAPs embryonic MCT share a common lineage. We show here mouse limb expressing transcription factor Osr1, differentiate into fibrogenic adipogenic vivo vitro defining FAP-like population. Genetic lineage...
Fibro-adipogenic progenitors (FAPs) are resident mesenchymal in adult skeletal muscle that support repair, but also give rise to fibrous and adipose infiltration response disease chronic injury. FAPs identified using cell surface markers do not distinguish between quiescent actively engaged the regenerative process. We have shown previously derived from cells express transcription factor Osr1 during development. Here we show at low levels frequency, however upon acute injury reactivate...
Abstract Skeletal muscle regeneration requires the coordinated interplay of diverse tissue-resident- and infiltrating cells. Fibro-adipogenic progenitors (FAPs) are an interstitial cell population that provides a beneficial microenvironment for stem cells (MuSCs) during regeneration. Here we show transcription factor Osr1 is essential FAPs to communicate with MuSCs macrophages, thus coordinating Conditional inactivation impaired reduced myofiber growth formation excessive fibrotic tissue...
Background Previous data indicated that the leucine-rich α-2 glycoprotein 1 (LRG1) pathway contributes to vascular dysfunction during cancer growth. Therapeutic targeting of LRG1 normalized tumor vessel and enhanced efficacy anti-cancer adoptive T cell therapy. A major clinical problem after allogeneic hematopoietic stem transplantation (alloHSCT) chimeric antigen receptor (CAR) T-cell therapy is induction hyperinflammatory side effects, which are typically associated with severe endothelial...
Coordinated development of muscles, tendons, and their attachment sites ensures emergence functional musculoskeletal units that are adapted to diverse anatomical demands among different species. How these tissues patterned functionally assembled during embryogenesis is poorly understood. Here, we investigated the morphogenesis extraocular muscles (EOMs), an evolutionary conserved cranial muscle group crucial for coordinated movement eyeballs visual acuity. By means lineage analysis,...
Heterotopic ossification is a disorder caused by abnormal mineralization of soft tissues in which signaling pathways such as BMP, TGFβ and WNT are known key players driving ectopic bone formation. Identifying novel genes related to the process important steps for future gene therapy disorders. In this study, we detect an inter-chromosomal insertional duplication female proband disrupting topologically associating domain causing ultra-rare progressive form heterotopic ossification. This...
In pituitary adenomas, early recurrences and resistance to conventional pharmacotherapies are common, but the mechanisms involved still not understood. The high expression of epidermal growth factor receptor 2 (HER2)/extracellular signal-regulated kinase (ERK1/2) signal observed in human together with low levels antimitogenic transforming beta (TBR2), encouraged us evaluate effect specific HER2 inhibition trastuzumab on experimental tumor cell its antiproliferative response TGFB1....
ABSTRACT Coordinated development of muscles, tendons, and their attachment sites ensures emergence functional musculoskeletal units that are adapted to diverse anatomical demands among different species. How these tissues patterned functionally assembled during embryogenesis is poorly understood. Here, we investigated the morphogenesis extraocular muscles (EOMs), an evolutionary conserved cranial muscle group crucial for coordinated movement eyeballs visual acuity. By means lineage analysis,...
ABSTRACT The lymphatic system is formed during embryonic development by the commitment of specialized endothelial cells (LECs) and their subsequent assembly in primary vessels. Although are continuous contact with mesenchymal adult tissues, role vasculature remains poorly characterized. Here, we show that a subpopulation expressing transcription factor Osr1 close association migrating LECs established vessels mice. Lineage tracing experiments revealed Osr1+ precede LEC arrival back embryo....
Abstract Fibro-adipogenic progenitors (FAPs) are resident mesenchymal in adult skeletal muscle that support repair, but also give rise to fibrous and adipose infiltration response disease chronic injury. FAPs currently identified using cell surface markers do not distinguish between quiescent actively engaged the regenerative process. We have shown previously derived from cells express transcription factor Osr1 during development. Here we show at low levels frequency, however upon acute...
Abstract The lymphatic system is formed during embryonic development by the commitment of specialized endothelial cells (LECs) and their subsequent assembly in primary vessels. While are continuous contact with mesenchymal adult tissues, role vasculature remains poorly characterized. Here, we show that a subpopulation expressing transcription factor Osr1 close association migrating LECs established vessels mice. Lineage tracing experiments revealed Osr1+ precede LEC arrival back embryo....
The emergence of lymph nodes (LNs) is orchestrated by lymphoid tissue organizer cells (LTos) that attract and retain inducer (LTis) at strategic positions in the embryo. Identity mode action applied LTos during first LTi attraction have remained poorly characterized. Here, we show expressing gene Osr1 are mesenchymal LTo progenitors. By dissecting Osr1+ cell heterogeneity demonstrate distinct signatures diverse anatomical locations reveal a common progenitor LN‐associated adipose tissue....
Abstract Skeletal muscle regeneration requires the coordinated interplay of diverse tissue-resident- and infiltrating cells. Fibro-adipogenic progenitors (FAPs) are an interstitial cell population that provides a beneficial microenvironment for stem cells (MuSCs) during regeneration. Here we show transcription factor Osr1 is essential FAPs to communicate with MuSCs macrophages, thus coordinating Conditional inactivation impaired reduced myofiber growth formation excessive fibrotic tissue...
We aimed to identify the underlying genetic cause for a novel form of distal arthrogryposis.Rare variant family-based genomics, exome sequencing, and disease-specific panel sequencing were used detect ADAMTS15 variants in affected individuals. Adamts15 expression was analyzed at single-cell level during murine embryogenesis. Expression patterns characterized using situ hybridization RNAscope.We identified homozygous rare alleles 5 individuals from 4 unrelated consanguineous families...