A5070084303- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Neonatal Respiratory Health Research
- Reproductive System and Pregnancy
- Connective tissue disorders research
- Congenital Diaphragmatic Hernia Studies
- Kruppel-like factors research
- Genetic Syndromes and Imprinting
- Heterotopic Ossification and Related Conditions
- MicroRNA in disease regulation
- GDF15 and Related Biomarkers
Mercy Hospital for Women
2023-2025
Max Delbrück Center
2023-2025
Charité - Universitätsmedizin Berlin
2023-2025
The University of Melbourne
2023-2025
German Centre for Cardiovascular Research
2023-2025
Humboldt-Universität zu Berlin
2023-2025
Freie Universität Berlin
2023-2025
Max Planck Institute for Molecular Genetics
2023
Abstract Preeclampsia results from placental insufficiency and causes maternal endothelial dysfunction multi-organ damage. Our in-silico analysis identified Cystatin 6 (CST6), a cysteine protease inhibitor, as located on the surface where it might be released into circulation. This study aimed to characterise CST6 one of its high affinity targets, Legumain (LGMN), in preeclampsia assess biomarker potential by measuring levels Placental mRNA expression was significantly increased 78...
Dysregulated progenitor cell populations may contribute to poor placental development and insufficiency pathogenesis. Side-population cells possess properties. Recent human trophoblast side-population isolation identified enrichment of 8 specific genes (CXCL8, ELL2, GATA6, HK2, HLA-DPB1, INTS6, SERPINE3 UPP1) (Gamage et al. 2020, Stem Cell Rev Rep). We characterised these markers in placenta disorders: preeclampsia fetal growth restriction (FGR). Trophoblast localised mononuclear...
Heterotopic ossification is a disorder caused by abnormal mineralization of soft tissues in which signaling pathways such as BMP, TGFβ and WNT are known key players driving ectopic bone formation. Identifying novel genes related to the process important steps for future gene therapy disorders. In this study, we detect an inter-chromosomal insertional duplication female proband disrupting topologically associating domain causing ultra-rare progressive form heterotopic ossification. This...
Preeclampsia (PE), a pregnancy-related complication, is major cause of maternal and fetal morbidity mortality. The pathophysiology not fully elucidated. Activin A GDF15 are part the TGFβ superfamily markers for trophoblast differentiation. Both senescence associated secretory phenotype (SASP) factors that have been with cardiovascular disease. Mitochondrial dysfunction SASP both described in PE. Serum levels A, were elevated blood prior to onset PE found be placental tissue women BeWo cells...