A5042481766- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Neonatal Respiratory Health Research
- Reproductive System and Pregnancy
- Congenital Diaphragmatic Hernia Studies
- Prenatal Screening and Diagnostics
- MicroRNA in disease regulation
- Renal and related cancers
- Galectins and Cancer Biology
- RNA modifications and cancer
- Circular RNAs in diseases
- Maternal and fetal healthcare
Mercy Hospital for Women
2021-2025
The University of Melbourne
2021-2024
University of Mississippi Medical Center
2024
Abstract Background: Preeclampsia is a severe complication of pregnancy. Chemerin an adipokine secreted from adipose tissue and highly expressed in placenta. This study evaluated the biomarker potential circulating chemerin to predict preeclampsia. Methods: Maternal plasma placenta were collected women with early-onset preeclampsia (<34 weeks), eclampsia, or before diagnosis (36 weeks). Human trophoblast stem cells differentiated into syncytiotrophoblast extravillous trophoblasts...
Background Preeclampsia is pregnancy specific, involving significant maternal endothelial dysfunction. Predictive biomarkers are lacking. We evaluated the biomarker potential, expression, and function of PSG7 (pregnancy-specific β-1 glycoprotein 7) PSG9 9) in preeclampsia. Methods Results At 36 weeks gestation preceding term preeclampsia diagnosis, (in Australian cohorts n=918 n=979, respectively) were significantly increased before onset (PSG7, P=0.013; PSG9, P=0.0011). In samples collected...
Biomarkers for placental dysfunction are currently lacking. We recently identified SPINT1 as a novel biomarker; SPINT2 is functionally related protease inhibitor. This study aimed to characterise expression in insufficiency. Circulating was assessed three prospective cohorts, collected at the following: (1) term delivery (n = 227), (2) 36 weeks 364), and (3) 24-34 weeks' 294) gestation. also measured plasma placentas of women with established disease preterm (<34 weeks) delivery. Using...
Preeclampsia is a disease of pregnancy responsible for significant maternal and neonatal mortality. Galectin-3 β-Galactoside binding protein. This study aimed to characterise galectin-3 in women with preeclampsia human trophoblast stem cells (hTSCs). was measured placental lysates plasma collected from patients early-onset (delivered <34 weeks' gestation) gestation matched controls. Placental protein significantly reduced 43 compared 21 mRNA expression LGALS3 (galectin-3 encoding gene) 29...
Preeclampsia is a severe complication of pregnancy which attributed to placental dysfunction. The retrotransposon, Paternal Expressed Gene 10 (PEG10) harbours critical functions pertaining trophoblast cells. Limited evidence exists on whether PEG10 involved in preeclampsia pathogenesis. This study characterised the expression and regulation placentas from patients with early-onset compared gestation-matched controls.PEG10 was measured plasma collected (< 34 weeks') controls using ELISA...
Abstract Fetal growth restriction is a leading cause of stillbirth that often remains undetected during pregnancy. Identifying novel biomarkers may improve detection pregnancies at risk. This study aimed to assess syndecan-1 as biomarker for small gestational age (SGA) or fetal restricted (FGR) and determine its molecular regulation. Circulating maternal was measured in several cohorts; large prospective cohort collected around 36 weeks’ gestation (n = 1206), case control from the Manchester...
Placental dysfunction is the leading cause of both preeclampsia and fetal growth restriction. This study aimed to characterize endothelial protein C receptor (EPCR) in preterm preeclampsia, term restriction (defined by delivery a small for gestational age [SGA] infant [<10% birthweight centile]) examine its regulation primary syncytiotrophoblast. EPCR mRNA were significantly increased patients with (<34 weeks gestation) compared gestation-matched controls (p < .0001). In plasma, was also...