A5038438044- Language Development and Disorders
- Neurobiology of Language and Bilingualism
- RNA Research and Splicing
- Autism Spectrum Disorder Research
- RNA and protein synthesis mechanisms
- Infant Development and Preterm Care
- RNA modifications and cancer
- Birth, Development, and Health
- Reading and Literacy Development
- Assistive Technology in Communication and Mobility
- Phonetics and Phonology Research
- Family and Disability Support Research
- Maternal Mental Health During Pregnancy and Postpartum
- Amino Acid Enzymes and Metabolism
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Pregnancy and preeclampsia studies
- Child and Adolescent Psychosocial and Emotional Development
- Voice and Speech Disorders
- Stuttering Research and Treatment
- Neonatal Respiratory Health Research
- Adolescent and Pediatric Healthcare
- Osteomyelitis and Bone Disorders Research
- Innovations in Medical Education
- Metabolism and Genetic Disorders
The University of Sydney
2013-2025
Google (United States)
2014-2024
Nationwide Children's Hospital
2024
Speech Pathology Australia
2024
Hofstra University
2023
Marquette University
2023
New York University
2023
University of Vermont
2023
Parliament of Australia
2023
University of Nottingham
2021
Although papillary thyroid carcinoma (PTC) displays strong heritability, no predisposing germ-line mutations have been found. We show that a common G/C polymorphism (rs2910164) within the pre-miR-146a sequence reduced amount of pre- and mature miR-146a from C allele 1.9- 1.8-fold, respectively, compared with G allele. This is matched by similar decrease in each pre-miR generated corresponding pri-miR-146a an vitro processing reaction. The also interfered binding nuclear factor to...
4E-transporter (4E-T) is one of several proteins that bind the mRNA 5'cap-binding protein, eukaryotic initiation factor 4E (eIF4E), through a conserved binding motif. We previously showed 4E-T nucleocytoplasmic shuttling which mediates import eIF4E into nucleus. At steady state, predominantly cytoplasmic and concentrated in bodies conspicuously resemble recently described processing (P-bodies), are believed to be sites decay. In this paper, we demonstrate colocalizes with decapping factors...
The gold standard for diagnosing childhood apraxia of speech (CAS) is expert judgment perceptual features. aim this study was to identify a set objective measures that differentiate CAS from other disorders.Seventy-two children (4-12 years age) diagnosed with suspected by community speech-language pathologists were screened. Forty-seven participants underwent diagnostic assessment including presence or absence Twenty-eight met two sets criteria (American Speech-Language-Hearing Association,...
This randomized controlled trial compared the experimental Rapid Syllable Transition (ReST) treatment to Nuffield Dyspraxia Programme-Third Edition (NDP3; Williams & Stephens, 2004), used widely in clinical practice Australia and United Kingdom. Both programs aim improve speech motor planning/programming for children with apraxia of (CAS), but they differ types stimuli used, level stimulus complexity at initiation treatment, principles learning that apply.Treatment was delivered 26 mild...
Behavioural/emotional problems may be common in preschool children living resource-poor settings, but assessment of these from poor areas is challenging owing to lack appropriate behavioural screening tools. The child behaviour checklist (CBCL) widely known for its reliability identifying behavioural/emotional children, it has not been validated use sub-Saharan Africa. With permission developers CBCL, we translated this tool into Ki-Swahili and adapted the items make them culturally...
Abstract Background There has been increasing interest in the relative effects of mothers' and fathers' interactions with their infants on later development. However to date there little work children's cognitive outcomes. Methods We examined influence sensitivity during children at end child's first year (10–12 months, n = 97), child general development 18 months language 36 months. Results Both parents' was associated outcomes univariate analyses. Mothers' sensitivity, however, appeared be...
Cross-cohort comparison is an established method for improving causal inference. This study compared 2 cohorts, 1 from a high-income country and another middle-income country, to (1) establish whether birth exposures may play role in the development of childhood attention problems; (2) identify confounding structures different parent-reported difficulties with deficit hyperactivity disorder (ADHD) diagnoses.Birth included low weight (LBW), small-for-gestational age (SGA), small head...
Chronic nonbacterial osteomyelitis (CNO) is an autoinflammatory bone disorder that if left untreated can result in destruction and severe continuing pain due to persistent inflammation. The impact this chronic disease has on the daily lives of affected children their families not well known. purpose study understand burden socioeconomic psychological CNO from patients' families' perspectives identify areas improvement for patient care reduced based responses.Participants were invited through...
Objectives To describe the construction of international INTERGROWTH-21st Neurodevelopment Assessment (INTER-NDA) standards for child development at 2 years by reporting cognitive, language, motor and behaviour outcomes in optimally healthy nourished children Project. Design Population-based cohort study, Setting Brazil, India, Italy, Kenya UK. Participants 1181 prospectively recruited from early fetal life according to prescriptive WHO approach, confirmed be low risk adverse perinatal...
Background We investigated the biomarker potential of growth differentiation factor 15 (GDF‐15), a stress response protein highly expressed in placenta, to predict preeclampsia. Methods and Results In 2 prospective cohorts (cohort 1: 960 controls, 39 women who developed preeclampsia; cohort 2: 950 41 preeclampsia), plasma concentrations GDF‐15 at 36 weeks' gestation were significantly increased among those preeclampsia ( P <0.001), area under receiver operating characteristic curves (AUC)...
The presence of two systems in Escherichia coli for gluconate transport and phosphorylation is puzzling. main system, GntI, well characterized, while the subsidiary GntII, poorly understood. Genomic sequence analysis region known to contain genes GntII system led a hypothesis which was tested biochemically confirmed: encodes pathway catabolism L-idonic acid D-gluconate an intermediate. have been named accordingly: idnK gene, encoding thermosensitive kinase, monocistronic transcribed...
The Escherichia coli eda gene, which encodes the Entner-Doudoroff aldolase, is central to catabolism of several sugar acids. Here, we show that Eda synthesis induced by growth on gluconate, glucuronate, or methyl-beta-D-glucuronide; phosphate limitation; and carbon starvation. Transcription initiates from three promoters, designated P1, P2, P4, each responsible for induction under different conditions. P1 controls gluconate regulated GntR. P2 glucuronate galacturonate KdgR. P4 active...
The A؉U-rich elements (or AREs) are cis-acting sequences that activate rapid mRNA decay, yet the overall polarity of this process is unknown.The current study describes an unbiased approach to using Invader RNA assay (Third Wave Technologies, Inc.) quantify decay each three exons human -globin without added instability or with AREs from c-fos granulocyte-macrophage colony-stimulating factor (GM-CSF) in 3 untranslated region.Each these genes under tetracycline operator control was stably...
Childhood Apraxia of Speech is an impairment speech motor planning that manifests as difficulty producing the sounds (articulation) and melody (prosody) speech. These difficulties may persist through life are detrimental to academic, social, vocational development. A number published single subject case series studies treatments available. There currently no randomised control trials or other well designed group available guide clinical practice. parallel group, fixed size trial will be...
speechBITE (http://www.speechbite.com) is an online database established in order to help speech and language therapists gain faster access relevant research that can used clinical decision-making. In addition containing more than 3000 journal references, the also provides methodological ratings on PEDro-P (an adapted version of PEDro) scale assist clinicians identifying scientific quality randomized (RCTs) non-randomized control trials (NRCTs). While reliability PEDro has been by similar...
This article uses the International Classification of Functioning (ICF) framework to outline assessment needs children with apraxia speech. Specifically, level breakdown for speech—that motor planning and programming at body functions—is delineated using operationally defined criteria greater diagnostic transparency.
Background The INTER-NDA is a novel assessment of early child development measuring cognition, language, motor skills, behaviour, attention, and socio-emotional reactivity in 2 year olds 15 minutes. Here, we present the results an evaluation against Bayley Scales Infant Development III edition (BSID-III), its sensitivity specificity psychometric properties. Methods Eighty-one infants from Oxford, UK, aged 23.1–28.3 months, were evaluated using BSID-III. agreement between BSID-III was...
Background There are an increasing number of reports on time trends in child and adolescent psychological problems but none from low‐ middle‐income countries, very few covering the preschool period. The aim was to investigate changes behavioral/emotional two birth cohorts a country born 11 years apart. Methods We analyzed data 1993 2004 Pelotas cohort studies Brazil. A subsample 4‐year olds (634) all (3750) were assessed for through maternal report using Child Behavior Checklist ( CBCL )....
Purpose Childhood apraxia of speech (CAS) is a disorder that many generalist speech-language pathologists feel underqualified to treat. For children with CAS, this may result in ad hoc interventions resulting slower progress. Research evidence for various CAS treatments primarily limited single-case experimental design studies; however, two (Rapid Syllable Transition Treatment [ReST] and the Nuffield Dyspraxia Programme, Third Edition) have been compared single randomized controlled trial....