A5035624917- Angiogenesis and VEGF in Cancer
- Lymphatic System and Diseases
- 14-3-3 protein interactions
- HER2/EGFR in Cancer Research
- Cell Adhesion Molecules Research
- Single-cell and spatial transcriptomics
- Atherosclerosis and Cardiovascular Diseases
- Lymphoma Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Barrier Structure and Function Studies
- Ubiquitin and proteasome pathways
- Zebrafish Biomedical Research Applications
- Estrogen and related hormone effects
- Immunotherapy and Immune Responses
- Bioinformatics and Genomic Networks
- Cancer-related gene regulation
- Computational Drug Discovery Methods
- RNA Research and Splicing
- Advanced Biosensing Techniques and Applications
- interferon and immune responses
- Glioma Diagnosis and Treatment
- Systemic Lupus Erythematosus Research
- RNA Interference and Gene Delivery
- Cancer Cells and Metastasis
- CAR-T cell therapy research
Uppsala University
2021-2023
Max Delbrück Center
2014-2023
Science for Life Laboratory
2022
Fraunhofer Society
2008
Dysfunctional and leaky blood vessels resulting from disruption of the endothelial cell (EC) barrier accompanies numerous diseases. The EC is established through tight adherens junctions. However, expression pattern precise contribution different junctional proteins to poorly understood. Here, we focus on organs with continuous endothelium identify structural functional in vivo characteristics barrier. Assembly multiple single-cell RNAseq datasets into a single integrated database revealed...
Abstract Background Patient-derived xenograft (PDX) models of glioblastoma (GBM) are a central tool for neuro-oncology research and drug development, enabling the detection patient-specific differences in growth, vivo response. However, existing PDX not well suited large-scale or automated studies. Thus, here, we investigate if fast zebrafish-based model, supported by longitudinal, AI-driven image analysis, can recapitulate key aspects growth enable case-comparative testing. Methods We...
The migration of lymphatic endothelial cells (LECs) is key for the development complex and vast vascular network that pervades most tissues in an organism. In zebrafish, arterial intersegmental vessels together with chemokines have been shown to promote cell from horizontal myoseptum (HM). We observed emergence mural around arteries coincides departure HM which raised possibility LEC migration. Our live imaging ablation experiments revealed LECs migrate slower fail establish absence cells....
Abstract Tumor-induced remodeling of the microenvironment relies on formation blood vessels, which go beyond regulation metabolism, shaping a maladapted survival niche for tumor cells. In high-grade B-cell lymphoma, angiogenesis correlates with poor prognosis, but attempts to target established proangiogenic pathways within vascular have been inefficient. Here, we analyzed Myc-driven lymphoma–induced in mice. A few lymphoma cells were sufficient activate angiogenic switch lymph nodes. unique...
<p>Influence of LT beta receptor signaling on HEVs</p>
<p>Top GO and GSEA pathways</p>
<p>Lack of inflammatory gene signatures</p>
<p>Influence of LT beta receptor signaling on HEVs</p>
<p>Solid tumors respond to VEGFR-2 inhibition</p>
<p>Lack of hypoxia and tip cell signature</p>
<p>Supplementary Material+Methods, Legends, References</p>
<p>Top GO and GSEA pathways</p>
<p>Solid tumors respond to VEGFR-2 inhibition</p>
<p>PNAd detection on DLBCL</p>
<p>Vascular permeability and leukocyte transmigration</p>
<p>Proliferation induction</p>
<p>PNAd detection on DLBCL</p>
<div>Abstract<p>Tumor-induced remodeling of the microenvironment relies on formation blood vessels, which go beyond regulation metabolism, shaping a maladapted survival niche for tumor cells. In high-grade B-cell lymphoma, angiogenesis correlates with poor prognosis, but attempts to target established proangiogenic pathways within vascular have been inefficient. Here, we analyzed <i>Myc</i>-driven lymphoma–induced in mice. A few lymphoma cells were sufficient activate...
<p>Lack of hypoxia and tip cell signature</p>