A5052230278- Veterinary Equine Medical Research
- Chronic Lymphocytic Leukemia Research
- Veterinary Orthopedics and Neurology
- Tendon Structure and Treatment
- Phagocytosis and Immune Regulation
- Immune Cell Function and Interaction
- Immunodeficiency and Autoimmune Disorders
- Spine and Intervertebral Disc Pathology
- Angiogenesis and VEGF in Cancer
- Acute Myeloid Leukemia Research
- 14-3-3 protein interactions
- Cell Adhesion Molecules Research
- HER2/EGFR in Cancer Research
- CAR-T cell therapy research
- Veterinary Oncology Research
- Lymphoma Diagnosis and Treatment
- Musculoskeletal synovial abnormalities and treatments
- Monoclonal and Polyclonal Antibodies Research
- Microbial infections and disease research
- Sports injuries and prevention
- Atherosclerosis and Cardiovascular Diseases
- Medical Imaging and Pathology Studies
- Education Methods and Technologies
- T-cell and B-cell Immunology
- Animal health and immunology
Leipzig University
2014-2024
Max Delbrück Center
2009-2024
Bielefeld University
2023
John Wiley & Sons (United States)
2022-2023
Hudson Institute
2023
University Hospital Leipzig
2018-2019
Asklepios Klinik Barmbek
2018
Onderstepoort Veterinary Academic Hospital
2018
University of Pretoria
2018
Freie Universität Berlin
2013
In human chronic lymphocytic leukemia (CLL) pathogenesis, B-cell antigen receptor signaling seems important for ontogeny, whereas the microenvironment influences activation, tumor cell lodging, and provision of antigenic stimuli. Using murine Eμ-Tcl1 CLL model, we demonstrate that CXCR5-controlled access to follicular dendritic cells confers proliferative stimuli B cells. Intravital imaging revealed a marginal zone cell-like trafficking route. Murine reciprocally stimulated resident...
Background: While point‐of‐care testing (POCT) is being used increasingly as a basis for deciding on perioperative erythrocyte transfusion, no valid standards currently exist concerning the accuracy of Hb concentration measurements. For clinical employment, however, confidence limits (±2 SD) these measurements should lie close to 5 g/l. The aim present study was evaluate and precision blood hemoglobin (cHb in g/l) critically ill patients. Methods: Fifty samples from 50 postoperative patients...
Recruitment of tumor-associated macrophages and neutrophils (TAM TAN) to solid tumors contributes immunosuppression in the tumor microenvironment; however, their contributions lymphoid neoplasms are less clear. In human chronic lymphocytic leukemia (CLL), B cells lodge lymph nodes where interactions with microenvironment occur. Tumor cell homing stimulates proliferation, such that engagement B-cell receptor is important for malignant progression. Eμ-Tcl1 murine model CLL, we identified gene...
Summary Reasons for performing study Reductions in distances between dorsal spinous processes on radiographs are used as criteria the diagnosis of impingement thoracic horses but potentially altered by spine motion and different head neck positions. Objectives To determine influence positions intervertebral spines clinically sound horses. Methods Lateral–lateral were obtained from 23 3 The width adjacent measured at points perpendicular to a tangent caudal extremity vertebrae. Results A low...
Sheep are commonly used as a model for human spinal orthopaedic research due to their similarity in morphological and biomechanical features. This study aimed document the volumes of vertebral bodies compare generated results well morphometry sheep lumbar spine published data. For this purpose, computed tomography scans were carried out on five adult Merino under general anaesthesia. Transverse 5 mm thick images acquired from L1 L6 using multi-detector-row helical CT scanner. Volume...
The advent of CAR T cells targeting CD19 or BCMA on B cell neoplasm demonstrated remarkable efficacy, but rapid relapses and primary refractoriness remains challenging. A leading cause failure is their lack expansion limited persistence. Long-lived, self-renewing multipotent memory stem (TSCM) central (TCM) likely sustain superior tumor regression, low frequencies in blood from cancer patients impose a major hurdle for clinical production. We designed clinically compliant protocol generating...
Treatment of tendon disease with multipotent mesenchymal stromal cells (MSC) is a promising option to improve tissue regeneration. To elucidate the mechanisms by which MSC support regeneration, longitudinal tracking labelled superparamagnetic iron oxide (SPIO) magnetic resonance imaging (MRI) could provide important insight. Nine equine patients suffering from were treated SPIO‐labelled or nonlabelled allogeneic umbilical cord‐derived local injection. Labelling was confirmed microscopy and...
Mediastinal large B-cell lymphomas (MLBCLs) are considered as a subtype of diffuse lymphoma; however, they exhibit completely different patterns dissemination. Since share number surface markers with thymic B cells, close relationship was assumed. MLBCLs arise extranodally within the anterior mediastinum and have low propensity to metastasize. To address preferential positioning MLBCL, we focused on homeostatic chemokines involved in compartmental homing secondary lymphoid organs, which also...
The sheep spine is widely used as a model for preclinical research in human medicine to test new spinal implants and surgical procedures. Therefore, precise morphometric data are needed. present study aimed provide computed tomographic (CT) morphometry of thoracolumbar spine. Five adult normal Merino were included this study. Sheep anaesthetised positioned sternal recumbency. Subsequently, transverse sagittal images obtained using multi-detector-row helical CT scanner. Measurements the...
Abstract Tumor-induced remodeling of the microenvironment relies on formation blood vessels, which go beyond regulation metabolism, shaping a maladapted survival niche for tumor cells. In high-grade B-cell lymphoma, angiogenesis correlates with poor prognosis, but attempts to target established proangiogenic pathways within vascular have been inefficient. Here, we analyzed Myc-driven lymphoma–induced in mice. A few lymphoma cells were sufficient activate angiogenic switch lymph nodes. unique...
Multiple myeloma (MM) is a plasma cell disease with preferential bone marrow (BM) tropism. Enforced expression of tissue-specific chemokine receptors has been shown to successfully guide adoptively-transferred CAR NK cells towards the malignant milieu in solid cancers, but also BM-resident AML and MM. For redirection BM-associated CXCL12, we armored BCMA CAR-NK-92 as well primary ectopic either wildtype CXCR4 or gain-of-function mutant R334X . Our data showed that -primary equipped gained an...
The aim of the study was to describe anatomy bovine tarsus using magnetic resonance imaging in a low-field scanner. T1-weighted transverse and sagittal images five isolated hindlimbs were evaluated 0.5 Tesla magnet knee coil. MR compared corresponding frozen sections cadaver limbs. Anatomical structures labelled at each level. resulting provided excellent detail tarsus. This should serve as basic reference for orthopaedic problems related cattle.
A retrospective analysis of 619 upper and lower cheek teeth from 62 horses was performed. Based on clinical findings, as well radiographic magnetic resonance (MR) imaging the were classified into five groups. There 20 with abnormal MR signals alterations 599 healthy teeth. Using imaging, appearance pulp in diseased disease‐free compared, studied. Subsequently, ability to diagnose pulpitis necrosis normal external investigated. In clinically verified dental disease, findings confirmed all...
The purpose of this study was to provide a detailed computed tomographic (CT) anatomic reference for the dromedary camel tarsus. Six cadaver pelvic limbs, obtained from three clinically and radiographically sound camels, were scanned in both soft tissue bone windows starting calcaneal tuber towards proximal metatarsus. Limbs frozen at −20°C sectioned transversely via an electric saw. CT images evaluated correlated with their corresponding cryosections. resulting provided features bones,...
Scintigraphic examination of the thoracic spine is well documented. However, there limited information about effects time on image quality in period following injection radionuclide. This study aimed to determine optimal point after 99m Tc‐HDP (hydroxymethylene‐diphosphonate) achieve scintigraphic images with best possible contrast and adequate count rates. 21 horses were acquired two, four six hours administering Tc‐HDP. Eight regions interest drawn images, spinous processes adjacent soft...
Abstract Background Osteochondral fragment removal is commonly performed but there are little scientific data supporting this procedure in the absence of clinical signs. More information needed to facilitate decision‐making regarding metacarpo−/metatarsophalangeal joint. Objectives To assess prevalence cartilage injury equine joint and its association size, location, age lameness. Study design Retrospective observational study. Methods Clinical records, including radiographs 823 joints (640...
Summary A 5‐year‐old Warmblood mare was presented to the clinic 8 h after being found by owners with luxation of second cervical vertebra. Clinically, horse showed an extended posture and reduced movement head neck. defined lateral swelling neck at level first vertebrae evident. Successful reduction achieved under general anaesthesia in recumbency using electrically powered hand pallet truck. The no neurological disorders before or reduction. Seven months incident could be ridden exhibited...
Many proteins mature within the secretory pathway by acquisition of glycans. Failure to maintain proper distribution glycosylation machinery might lead disease. High expression levels ubiquitous Golgi protein estrogen receptor-binding fragment-associated gene 9 (EBAG9) in human tumors correlate with poor clinical prognosis, and EBAG9 overexpression epithelial cell lines induces truncated glycans, typical many carcinomas. Here, we addressed pathogenetic link between alteration cellular...
Abstract This prospective, cross‐sectional, pilot study aimed to investigate the effects of furosemide as a diuretic on image quality bone scintigraphy performed using 99m Tc‐HDP and impact radiation dose rate. Thirty‐one horses undergoing were included. The divided into control (n = 14) group 17), which received 1 mg/kg intravenously h post administration. was assessed subjectively semi‐quantitatively. bone‐to‐soft tissue (B:S) ratio calculated from counts per pixel regions interest (ROI)...
The objective of this study was to provide a detailed multiplanar computed tomographic (CT) anatomic reference for the bovine tarsus. tarsal regions from twelve healthy adult cow cadavers were scanned in both soft and bone windows via 16-slice multidetector CT scanner. Tarsi frozen at −20o C sectioned 10-mm-thick slices transverse, dorsal sagittal planes respecting imaging protocol. sections cleaned then photographed. Anatomic structures identified, labelled compared with corresponding...