A5002873690- Advanced Chemical Sensor Technologies
- Bone and Joint Diseases
- Analytical Chemistry and Chromatography
- Bone Metabolism and Diseases
- Mesenchymal stem cell research
- Insect Pheromone Research and Control
- RNA and protein synthesis mechanisms
- Bone fractures and treatments
- Hematopoietic Stem Cell Transplantation
- Gas Sensing Nanomaterials and Sensors
- Influenza Virus Research Studies
- Biochemical Analysis and Sensing Techniques
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2020-2023
University of Rostock
2018-2020
Influenza is one of the most common causes virus diseases worldwide. Virus detection requires determination RNA in upper respiratory tract. Efficient screening not possible this way. Analysis volatile organic compounds (VOCs) breath holds promise for non-invasive and fast monitoring disease progression. Breath VOC profiles 14 (3 controls 11 infected animals) swine were repeatedly analyzed during a complete infection cycle A under high safety conditions. VOCs pre-concentrated by means needle...
Abstract Influenza A is a serious pathogen itself, but often leads to dangerous co-infections in combination with bacterial species such as Streptococcus pyogenes . In comparison classical biochemical methods, analysis of volatile organic compounds (VOCs) headspace above cultures can enable destruction free monitoring metabolic processes vitro Thus, biomarkers emitted from biological cell and pathogens could serve for infection this study we analysed VOCs (co)-infected human cells by using...
Background: The healing of a bone injury is highly complex process involving multitude different tissue and cell types, including immune cells, which play major role in the initiation progression regeneration. Methods: We histologically analyzed spatio-temporal occurrence cells innate system (macrophages), adaptive (B T lymphocytes), (osteoblasts osteoclasts) fracture area femoral osteotomy over time. This study was performed gap mouse model. also investigated two key challenges successful...
The interaction of hematopoietic cells and the bone microenvironment to maintain homeostasis is increasingly appreciated. We hypothesized that transfer allogeneic T lymphocytes has extensive effects on biology investigated trabecular cortical structures, osteoblast reconstitution, vasculature in experimental stem cell transplantations (HSCT). Allogeneic or syngeneic (HSC) were isolated transferred a murine model. After 20, 40, 60 days, structures visualized using microCT histology. Immune...
Breath analysis holds promise for non-invasive in vivo monitoring of disease related processes. However, physiological parameters may considerably affect profiles exhaled volatile organic substances (VOCs). Volatile can be released via alveoli, bronchial mucosa or from the upper airways. The aim this study was systematic investigation influence different sampling sites respiratory tract on VOC concentration by means a novel experimental setup. After ethical approval, breath samples were...