A5007568818- Advanced Chemical Sensor Technologies
- Respiratory Support and Mechanisms
- Olfactory and Sensory Function Studies
- Gut microbiota and health
- Anesthesia and Sedative Agents
- Metabolomics and Mass Spectrometry Studies
- Analytical Chemistry and Sensors
- Biosensors and Analytical Detection
- Analytical Chemistry and Chromatography
- Gas Sensing Nanomaterials and Sensors
- Cardiac Arrest and Resuscitation
- Diet and metabolism studies
- Microfluidic and Capillary Electrophoresis Applications
- Analytical chemistry methods development
- Antibiotic Resistance in Bacteria
- Poisoning and overdose treatments
- Insect Pheromone Research and Control
- Antibiotics Pharmacokinetics and Efficacy
- Infection Control and Ventilation
- Neurological Disorders and Treatments
- Clostridium difficile and Clostridium perfringens research
- Respiratory viral infections research
- Animal Behavior and Welfare Studies
- Probiotics and Fermented Foods
- Oral health in cancer treatment
University of Rostock
2012-2024
University of Bern
2023-2024
Agroscope
2022-2023
Federal Department of Economic Affairs, Education and Research
2023
In-Q-Tel
2009
North Tyneside General Hospital
1997
Mercy Hospital Springfield
1983
Hartford Hospital
1979-1980
Hartford Financial Services (United States)
1979
Abstract There is experimental evidence that volatile substances in human breath can reflect presence of neoplasma. Volatile aldehydes were determined exhaled 12 lung cancer patients, smokers and healthy volunteers. Alveolar samples collected under control expired CO 2 . Reactive transformed into stable oximes by means on‐fiber‐derivatization (SPME‐OFD). Aldehyde concentrations the ppt ppb level gas chromatography‐mass spectrometry (GC‐MS). Exhaled corrected for inspired values. C 1 – 10...
This study was intended to evaluate low-volume (20 mL) multibed needle trap (NTD) sampling combined with heart-cut gas chromatography/mass spectrometry (GC/MS) and comprehensive two-dimensional chromatography/time-of-flight mass (GC × GC/TOF-MS) for trace analysis under clinical conditions. NTDs, high-throughput automatic desorption separation systems, were tested in vitro within a 11 patients undergoing cardiac surgery respect reproducibility, reliability, applicability. NTD−heart-cut GC/MS...
Background While assumed to protect against coronavirus transmission, face masks may have effects on respiratory–haemodynamic parameters. Within this pilot study, we investigated immediate and progressive of FFP2 surgical exhaled breath constituents physiological attributes in 30 adults at rest. Methods We continuously monitored profiles within mask space older (age 60–80 years) young middle-aged 20–59 over the period 15 min by high-resolution real-time mass-spectrometry. Peripheral oxygen...
Abstract Background Volatile breath biomarkers provide a non-invasive window to observe physiological and pathological processes in the body. This study was intended assess impact of heart surgery with extracorporeal circulation (ECC) onto biomarker profiles. Special attention attributed oxidative or metabolic stress during circulation, which can cause organ damage poor outcome. Methods 24 patients undergoing cardiac were enrolled into this observational study. Alveolar samples (10 mL) taken...
In this research we present a low-cost system for breath acetone analysis based on UV-LED photoacoustic spectroscopy. We considered the end-tidal phase of exhalation, which represents systemic concentrations volatile organic compounds (VOCs) – providing clinically relevant information about human health. This is achieved via development CO2-triggered sampling system, collected alveolar over several minutes in sterile and inert containers. A real-time mass spectrometer coupled to serve as...
Breath volatile organics (VOCs) may provide immediate information on infection mechanisms and host response. We conducted real-time mass spectrometry-based breath profiling in 708 non-preselected consecutive subjects the screening scenario of a COVID-19 test center. Recruited were grouped based PCR-confirmed status presence or absence flu-like symptoms. Exhaled VOC profiles SARS-CoV-2-positive cases (n = 36) differed from healthy 256) those with other respiratory infections 416)....
Noninvasive breath analysis may provide valuable information for cancer recognition if disease-specific volatile biomarkers could be identified. In order to compare nondiseased and diseased tissue in vivo , this study took advantage of the special circumstances one-lung ventilation (OLV) during lung-surgery. 15 patients undergoing lung resection with OLV were enrolled. From each patient, alveolar samples taken separately from healthy lungs before after tumour resection. Volatile substances...
Due to their immediate exhalation after generation at the cellular/microbiome levels, exhaled volatile organic compounds (VOCs) may provide real-time information on pathophysiological mechanisms and host response infection. In recent years, metabolic profiling of most frequent respiratory infections has gained interest as it holds potential for early, non-invasive detection pathogens monitoring disease progression therapy. Using previously unpublished data, randomly selected individuals from...
We aimed to gain insights in a co-culture of 10 bacteria and their postbiotic supernatant.
Patients with end-stage renal disease (ESRD) are at risk for a numerous complications. This study was intended to evaluate breath analysis monitoring and therapy initiation under haemodialysis (HD). Exhaled alveolar air from 30 ESRD patients during 4 h thrice-weekly HD analysed by means of HS-SPME-GC-MS. Venous blood samples were taken determination conventional serum parameters. concentrations isoprene (10-589 ppbV) dropped increased the end HD. Isoprene concentration changes similar LDH...
Contemporary resuscitation guidelines for basic life support recommend an immediate onset of cardiac compressions in case arrest followed by rescue breaths. Effective ventilation is often omitted due to fear doing harm and infectious diseases. In order improve a pre-stage automatic respirator was developed use laypersons. Fifty-two healthy volunteers were ventilated means prototype via full-face mask pilot study. The public access ventilator (PAV) consisted low-cost self-designed turbine,...
Cancer therapy is often associated with severe side effects such as drug induced weight loss, also known chemotherapy-induced cachexia. The aim of this study was to investigate the a multispecies probiotic (OMNi-BiOTiC® 10 AAD) in chemotherapy mouse model. A total 24 male BALB/c mice were gavage-fed formulation or water, once day for 3 weeks. In third week, received intraperitoneal cyclophosphamide. At euthanasia, organs dissected, and serum sampled cytokine analysis. Tight junction...
We aimed to assess the in vitro antimicrobial activity and vivo effect on murine fecal microbiome volatile organic compound (VOC) profile of (S)-reutericyclin. The (S)-reutericyclin was tested against Clostridium difficile, Listeria monocytogenes, Escherichia coli, Enterococcus faecium, Staphylococcus aureus, (S.) epidermidis, Streptococcus agalactiae, Pseudomonas aeruginosa Propionibacterium acnes. Reutericyclin or water were gavage fed male BALBc mice for 7 weeks. Thereafter stool samples...
Background: Probiotics are generally considered as safe, but infections may rarely occur in vulnerable patients. Alternatives to live microorganisms manage dysbiosis be of interest these Reuterin is a complex component system exhibiting broad spectrum antimicrobial activity and possible candidate substance cases. Methods: supernatant was cultured from Lentilactobacillus diolivorans bioreactor two-step process. Storage stability at −20°C effect repeated freeze-thaw cycles were assessed by...
Ultra- and circadian activity rhythms of animals can provide important insights into animal welfare. The consistency behavioral patterns is characteristic healthy organisms, while changes in the regularity may indicate health stress-related challenges. This pilot study aimed to examine whether dairy cows free-stall barns with an automatic milking system (AMS) free cow traffic develop ultra- rhythms. On 4 farms, pedometers recorded 10 each over 28 days. Based on time series calculation,...
Due to their immediate exhalation after generation at the cellular level exhaled volatile organics (VOCs) may provide real-time information on pathophysiological mechanisms and host response infections. We conducted mass-spectrometry based consecutive breath profiling in 708 subjects under conditions of a realistic screening scenario COVID-19 test center. Recruited were grouped for further comparisons, PCR confirmed infection status (infected by SARS-CoV-2 or other respiratory pathogens...