A5037650415- Congenital Diaphragmatic Hernia Studies
- Esophageal and GI Pathology
- Intestinal Malrotation and Obstruction Disorders
- Tracheal and airway disorders
- Congenital Anomalies and Fetal Surgery
- Diet and metabolism studies
- Congenital gastrointestinal and neural anomalies
- Gut microbiota and health
- Gastrointestinal disorders and treatments
- Neonatal Respiratory Health Research
- Pediatric Urology and Nephrology Studies
- Minimally Invasive Surgical Techniques
- Bariatric Surgery and Outcomes
- Appendicitis Diagnosis and Management
- Gastroesophageal reflux and treatments
- Neuroblastoma Research and Treatments
- Hernia repair and management
- Dysphagia Assessment and Management
- Orthopedic Surgery and Rehabilitation
- Bone fractures and treatments
- Abdominal Surgery and Complications
- Obesity and Health Practices
- Urological Disorders and Treatments
- Renal and related cancers
- Sports injuries and prevention
Medical University of Graz
2015-2024
Universitätsklinik für Kinder und Jugendpsychiatrie
2013-2024
Imperial College London
2024
Royal College of Paediatrics and Child Health
2024
The London College
2024
Graz University Hospital
2017-2023
Austrian Society of Cardiology
2021
Pediatric Oncology Group
2021
Charité - Universitätsmedizin Berlin
2020
Universität Hamburg
2020
Summary Recent research has disclosed a tight connection between obesity, metabolic gut microbial activities and host health. Obtaining complete understanding of this relationship remains major goal. Here, we conducted comparative metagenomic metaproteomic investigation communities in faecal samples taken from an obese lean adolescent. By analysing the diversity 16S rDNA amplicons (10% operational phylogenetic units being common), 22 Mbp consensus metagenome sequences (∼ 70% common)...
Obesity is associated with multiple adverse health effects and a high risk of developing metabolic cardiovascular diseases. Therefore, there great need to identify circulating parameters that link changes in body fat mass obesity. This study combines proteomic metabolomic approaches molecules discriminate healthy lean from obese individuals an exploratory design. To correct for variations physical activity, participants performed one hour exercise bout exhaustion. Subsequently, factors...
Accumulation of fat mass in obesity may result from hypertrophy and/or hyperplasia and is frequently associated with adipose tissue (AT) dysfunction adults. Here we assessed early alterations AT biology function by comprehensive experimental clinical characterization 171 samples lean obese children aged 0 to 18 years. We show an increase adipocyte size number compared beginning childhood. These composition were accompanied decreased basal lipolytic activity significantly enhanced stromal...
Use of PET/MR in children has not previously been reported, to the best our knowledge. Children with systemic malignancies may benefit from reduced radiation exposure offered by PET/MR. We report initial experience hybrid imaging and current established sequence protocol after 21 studies 15 multifocal malignant diseases. The effective dose a scan was only about 20% that equivalent PET/CT examination. Simultaneous acquisition PET MR data combines advantages two separate modalities....
Due to their fundamentally different biology, archaea are consistently overlooked in conventional microbiome surveys. Using amplicon sequencing, we evaluated methodological set-ups detect samples from five body sites: respiratory tract (nasal cavity), digestive (mouth, appendix, and stool) skin. With optimized protocols, the detection of archaeal ribosomal sequence variants (RSVs) was increased one (found currently used, so-called "universal" approach) 81 RSVs a representative sample set....
Fusions involving NTRK1, NTRK2, and NTRK3 are oncogenic drivers occurring in a spectrum of mesenchymal neoplasms ranging from benign to highly malignant tumors. To gain further insights into the staining profile with pan-TRK assay, we analyzed large number soft tissue sarcomas correlated our findings molecular testing. Additionally, expand NTRK-fusion tumors by reporting lesion lung as well skin fibrous histiocytoma NTRK-fusion. We retrospectively reviewed diagnosed at Diagnostic Research...
Recent studies suggested the persistence of brown adipocytes in adult humans, as opposed to being exclusively present infancy. In this study, we investigated presence brown-like adipose tissue (AT) samples children and adolescents aged 0 18 years evaluated association with age, location, obesity. For this, analysed AT from 131 23 adults by histological, immunohistochemical expression analyses. We detected UCP1 positive 10.3% 87 lean (aged 0.3 10.7 years) one overweight infant, whereas did...
Since the first description in 1998, minimally invasive repair of pectus excavatum has gained increasing acceptance. The aim this survey is to report on experiences eight European centres with technique.
The digestion of food ingredients depends on the action gut microbiota and has a significant influence health, especially in case metabolic diseases, host organism. Despite relevance structure functionalities for metabolism host, spatial resolution microbial consortia different sections rat are mostly unknown. Since there suitable models human is special interest. Samples along intestinal tract rats were investigated using metaproteomics 16S rRNA gene pyrosequencing. procedures harvesting...
Recent advances in the vitro characterization of human adult enteric neural progenitor cells have opened new possibilities for cell-based therapies gastrointestinal motility disorders. However, whether these are able to integrate within an vivo gut environment is still unclear. In this study, we transplanted progenitor-containing neurosphere-like bodies (NLBs) a mouse model hypoganglionosis and analyzed cellular integration NLB-derived cell types functional improvement. NLBs were propagated...
<b>Introduction</b> We present the experiences from two European centers performing Foker technique (FT) of esophageal lengthening by axial traction and Kimura advancement (KA) method upper pouch extrathoracic resiting a spit fistula (SF) in children with long-gap atresia (LGEA, gap length > 5 cm). <b>Materials Methods</b> A total 15 were treated (8 pure EA, 6 lower tracheoesophageal [TEF], 1 TEF). Gaps ranged to 14 cm. Nine already had SF. Patients grouped according presence SF subsequent...
Mounting evidence suggests that acute appendicitis (AA) is not one but two diseases: complicated appendicitis, which associated with necrosis leading to perforation or periappendicular abscess, and uncomplicated does necessarily result in perforation. Even though AA the most frequent cause of surgery from abdominal pain, little known about origins etiopathogenesis this disease, much less regarding different disease types. In study, we investigated microbiome (inter-domain amplicon metagenome...
objectives were to investigate the relations between associated anomalies and ARM types, timing of reconstructive surgery. Subjects data collectionARM patients under 18 years age treated in one ARM-Net Consortium registered registry until 1 March 2023 included.Each centre has a lead paediatric surgeon who is responsible for patient registration collection at their respective centre.Patient are de-identified pseudonymized before collection.Surgeons can only re-identify own with personal...
Proton pump inhibitors (PPIs) are the standard therapy for gastroesophageal reflux disease. In adults, PPI treatment is associated with Clostridium difficile infections (CDI). contrast to adults microbiome of infants develops from sterility at birth towards an adult-like profile in first years life. The effect PPIs on this developing has never been studied. aim present study was determine oral fecal disease (GERD). prospective longitudinal 12 proven GERD received a mean period 18 weeks...
Background: This study aimed to report a European multi-institutional experience about thoracoscopic management of children with congenital lung malformations. Methods: The records 102 patients (49 girls and 53 boys) median age at surgery 1 year (range 6 months-1.5 years), who underwent lobectomy in five Pediatric Surgery units, were retrospectively collected. Indications for included pulmonary airway malformation (CPAM) (n = 47), intra- extralobar sequestration 34), hybrid lesion...
No AccessJournal of UrologyInvestigative Urology1 Aug 2004CAJAL-LIKE CELLS IN THE HUMAN UPPER URINARY TRACT ROMAN METZGER, TOBIAS SCHUSTER, HOLGER TILL, MAXIMILIAN STEHR, FOLKER-ERNST FRANKE, and HANS-GEORG DIETZ METZGERROMAN METZGER , SCHUSTERTOBIAS SCHUSTER TILLHOLGER TILL STEHRMAXIMILIAN STEHR FRANKEFOLKER-ERNST FRANKE DIETZHANS-GEORG View All Author Informationhttps://doi.org/10.1097/01.ju.0000130571.15243.59AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack...
Introduction: Laparoendoscopic single-site surgery (LESS) represents the latest innovation in laparoscopic surgery. We compare dry and animal laboratory efficacy of recently introduced pre-bent instruments with conventional flexible terms time requirement, maneuvrability, ease handling. Materials Methods: Participants varying experience were included study divided groups according to their experience. The participants performed predetermined tasks using all sets instruments. An experienced...