A5012206251- Sarcoma Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Cardiac tumors and thrombi
- Vascular Tumors and Angiosarcomas
- Soft tissue tumor case studies
- Management of metastatic bone disease
- Orthopedic Surgery and Rehabilitation
- Orthopedic Infections and Treatments
- Cancer Immunotherapy and Biomarkers
- Bone fractures and treatments
- Cancer-related gene regulation
- Oral and Maxillofacial Pathology
- Epigenetics and DNA Methylation
- Renal and related cancers
- Lower Extremity Biomechanics and Pathologies
- Surgical site infection prevention
- Spine and Intervertebral Disc Pathology
- Foot and Ankle Surgery
- Neurofibromatosis and Schwannoma Cases
- Eosinophilic Disorders and Syndromes
- Genomic variations and chromosomal abnormalities
- Tendon Structure and Treatment
- Medical Imaging and Pathology Studies
- Cancer Cells and Metastasis
- Artificial Intelligence in Healthcare and Education
Medical University of Graz
2012-2024
University of Graz
2005-2021
Fusions involving NTRK1, NTRK2, and NTRK3 are oncogenic drivers occurring in a spectrum of mesenchymal neoplasms ranging from benign to highly malignant tumors. To gain further insights into the staining profile with pan-TRK assay, we analyzed large number soft tissue sarcomas correlated our findings molecular testing. Additionally, expand NTRK-fusion tumors by reporting lesion lung as well skin fibrous histiocytoma NTRK-fusion. We retrospectively reviewed diagnosed at Diagnostic Research...
Introduction Since its introduction in November 2022, the artificial intelligence large language model ChatGPT has taken world by storm. Among other applications it can be used patients as a source of information on diseases and their treatments. However, little is known about quality sarcoma-related provides. We therefore aimed at analyzing how sarcoma experts evaluate ChatGPT’s responses inquiries assess bot’s answers specific evaluation metrics. Methods The to sample 25 questions (5...
The standard definition of 'rare cancer' is a malignant disorder with an incidence <6 per 100 000 year according to the Surveillance Rare Cancers in Europe (RARECARE), wide variety for different rare cancers.
Round cell sarcomas are a heterogeneous group of mesenchymal neoplasms with overlapping morphology and immunohistochemical profile. Ewing sarcoma is the most well-known tumour in this characterised by EWSR1/FUS rearrangements members ETS family transcription factors. Undifferentiated round lacking these rearrangements, known as 'Ewing-like' sarcomas, usually show atypical clinical presentation focal CD99 positivity. This tumours can be subdivided into: capicua transcriptional repressor...
Soft tissue sarcomas (STS) are considered non-immunogenic, although distinct entities respond to anti-tumor agents targeting the tumor microenvironment. This study's aims were investigate relationships between tumor-infiltrating immune cells and patient/tumor-related factors, assess their prognostic value for local recurrence (LR), distant metastasis (DM), overall survival (OS).One-hundred-eighty-eight STS-patients (87 females [46.3%]; median age: 62.5 years) retrospectively analyzed. Tissue...
This retrospective study aimed at analyzing the impact of metastasectomy on post-metastasis survival (PMS) in bone sarcoma patients with lung metastases. Altogether, 47 (24 males, median age diagnosis metastases: 21.8 (IQR: 15.6-47.3) years) primary (n = 8) or secondary 39) metastases treated a single university hospital were retrospectively included. Based propensity score, inverse probability treatment weight (IPTW) was calculated to account for selection bias whether had undergone not....
Background: Bunionette is a common deformity for which number of operative procedures have been described. The objective this study was to evaluate the results modified distal horizontal metatarsal osteotomy in correction symptomatic bunionette. Methods: Metatarsal osteotomies were done 21 feet 14 patients (11 females, three males) with an average age 44 (range 20 67) years at time operation. followup 32 12 52) months. Results: Lesser Toe Metatarsophalangeal-Interphalangeal Score American...
To achieve clear margins in rare malignant clavicular neoplasms, claviculectomy may become necessary. This study aimed to review clinical, functional, and oncologic outcomes following partial or total without reconstruction.This retrospectively included 15 patients from 2 tertiary sarcoma centers (mean age, 42.6 ± 20.3 years; 66.7% male patients). The median length of clinical follow-up was 48.0 months (interquartile range [IQR], 24.0-83.5 months). Functional (Musculoskeletal Tumor Society...
In the last decade, new tumor entities have been described, including EWSR1/FUS::NFATC2-rearranged neoplasms of different biologic behavior. To gain further insights into behavior these tumors, we analyzed a spectrum and discuss their key diagnostic molecular features in relation to prognosis. We report five patients with neoplasms, one simple bone cyst (SBC), two complex cystic lesions lacking morphological characteristics SBC, sarcomas. three cases, fluorescence situ hybridization (FISH)...
Silver-coated megaprostheses are considered to reduce infection rate following reconstruction of bone defects in tumour surgery or revision arthroplasty. However, little is known about systemic silver exposure and possible side effects. The aim this study was analyse serum concentrations patients with silver-coated over a prolonged time period. Between 2004 2016, 46 (52.2% female, mean age at 47.1 ± 24.2 years) received for septic (n = 26) oncological 17; main implant since 2013)...
Scheipl, Susanne; Leithner, Andreas MD; Radl, Roman Beham-Schmid, Christine Ranner, Gerhard Linkesch, Werner Windhager, Reinhard MD Author Information
Soft tissue sarcomas are a group of rare mesenchymal neoplasms comprising 0.8% all malignant tumors. Workup should include medical history, physical examination, magnetic resonance imaging, biopsy, and thoracoabdominal computed tomography scan, in that order. Centralized multimodality treatment cross-disciplinary setting is mandatory. Treatment not according to current clinical practice guidelines common problem before referral specialized institution. The purpose this 10-year,...
Elastofibroma dorsi is a benign soft tissue lesion composed of abnormal elastic fibers. Degenerated fibers in skin and liver are associated with clusterin, an apoprotein that shares functional properties small heat shock proteins. We evaluated the staining pattern possible role clusterin elastofibroma dorsi.Twenty-one subcutaneous elastofibromas from scapular region were Elastica van Gieson Orcein stains, immunohistochemically antibodies to smooth muscle actin, S-100, vimentin CD34...
Abstract Purpose Drug screening programmes have revealed epidermal growth factor receptor inhibitors (EGFR i s) as promising therapeutics for chordoma, an orphan malignant bone tumour, in the absence of a known genetic driver. Concurrently, irreversible EGFR afatinib (Giotrif®) is being evaluated multicentric Phase II trial. As tyrosine kinase inhibitor (TKI) monotherapies are invariably followed by resistance, we aimed to evaluate potential therapeutic combinations with s. Methods We...
Molecular diagnosis has become an established tool in the characterisation of adult soft-tissue sarcomas (STS). FoundationOne® Heme analyses somatic gene alterations via DNA and RNA-hotspot sequencing tumour-associated genes.We evaluated testing 81 localised STS including 35 translocation-associated 46 complex-karyotyped cases from a single institution.Although achieved broad patient coverage identified at least five genetic each sample, sensitivity for fusion detection was rather low,...
Cellular myxoma is a benign soft tissue tumor frequently associated with GNAS mutation that may morphologically resemble low-grade myxofibrosarcoma. This study aimed to identify the undescribed methylation profile of cellular and compare it We performed molecular analysis on twenty myxomas nine myxofibrosarcomas analyzed results using methylation-based DKFZ sarcoma classifier. A total 90% had mutations (four loci not been previously described). Copy number variations were found in all but...
Tumour-to-tumour metastasis (TTM) occurs when one tumour metastasises to a separate within the same individual. TTM is observed frequently in breast cancer but has not been described male cancer. In addition reports describing solitary fibrous tumours (SFT) of pleura hosting other neoplasms' metastases are limited. We report an exceptional case metastasising extrapleural SFT, occurring subcutaneous tissue back 68-year old Caucasian patient.A was diagnosed with ductal He treated by mastectomy...