A5016409767- Sarcoma Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Vascular Tumors and Angiosarcomas
- Cardiac tumors and thrombi
- Musculoskeletal synovial abnormalities and treatments
- Management of metastatic bone disease
- Cancer Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Orthopaedic implants and arthroplasty
- Surgical site infection prevention
- Medical Imaging and Pathology Studies
- Oral and Maxillofacial Pathology
- Bone health and treatments
- CAR-T cell therapy research
- Colorectal and Anal Carcinomas
- Tumors and Oncological Cases
- Reconstructive Surgery and Microvascular Techniques
- Orthopedic Infections and Treatments
- Soft tissue tumors and treatment
- Pelvic and Acetabular Injuries
- Bone fractures and treatments
- Advanced Numerical Analysis Techniques
- Elbow and Forearm Trauma Treatment
- Salmonella and Campylobacter epidemiology
- Body Contouring and Surgery
Helios Hospital Berlin-Buch
2015-2024
Erasmus MC Cancer Institute
2020-2021
Helios Klinikum Emil von Behring
2015
Klinikum Stuttgart
2015
Vivantes Klinikum
2015
Charité - Universitätsmedizin Berlin
2000-2010
Universitätszahnklinik Wien
2009
Medical University of Vienna
2009
Max Delbrück Center
2001-2004
Humboldt-Universität zu Berlin
1995
EURAMOS-1, an international randomized controlled trial, investigated maintenance therapy with pegylated interferon alfa-2b (IFN-α-2b) in patients whose osteosarcoma showed good histologic response (good response) to induction chemotherapy.
The use of adjuvants after curettage has been well established for the treatment giant cell tumor bone. purpose this study was to analyze rates recurrence following different types as influence various factors presentation on those rates.The data regarding benign tumors appendicular skeleton from ten bone centers were evaluated. Axial and malignant excluded. associated with modalities analyzed, hazard ratios a calculated multiple presentation.The included 384 surgical procedures, involving...
Abstract Osteosarcomas are aggressive bone tumours with a high degree of genetic heterogeneity, which has historically complicated driver gene discovery. Here we sequence exomes 31 and decipher their evolutionary landscape by inferring clonality the individual mutation events. Exome findings interpreted in context SNP array data from replication set 92 tumours. We identify 14 genes as main drivers, some were formerly unknown osteosarcoma. None drivers is clearly responsible for majority even...
Background and purpose There have been few long-term studies on the outcome of chondrosarcoma findings regarding prognostic factors are controversial. We examined a homogeneous group patients with primary central bone who were treated according to uniform surgical protocol at our institution, in order determine that influence survival identify potential improvements therapeutic algorithm.Patients methods performed retrospective analysis 115 presented localized disease had minimum follow-up 5...
Studies focusing on the oncological outcome after treatment of conventional primary central chondrosarcoma pelvic bone are lacking. We conducted this retrospective study at 5 referral centers to gain insight in for tumor type and identify risk factors impaired outcome.One hundred sixty-two consecutive patients (118 male [73%]) who underwent resection a from 1985 2013 were evaluated. The median age was 51 years (range, 15 78 years). follow-up 12.6 (95% confidence interval [CI], 8.4 16.9 There...
The objective of this study was to evaluate noninvasive magnetic resonance (MR) thermography for the monitoring regional hyperthermia (RHT) in patients with soft tissue sarcomas lower extremities and pelvis.Noninvasive MR during RHT performed 9 who had high-risk or pelvis neoadjuvant chemotherapy plus scope European Organization Research Treatment Cancer 62961/European Society Hyperthermic Oncology RHT-95 study. Anatomic temperature-sensitive data sets were acquired every 10 minutes before...
Unplanned excisions (UE) of soft tissue sarcomas (STS) carry a high risk for local recurrence (LR) due to marginal/intralesional resections. However, there are reports about improved prognosis UE patients who have re-resection compared with undergo planned surgery. The present multicentre study was designed define characteristics and investigate the impact on subsequent therapy patient outcomes. A total 728 STS (376 males, 352 females; mean age: 58 years) underwent definite surgery at one...
The objective of this study was to investigate potential correlations between pathologic fractures (PFs) and prognosis patients with primary central high-grade osteosarcoma the extremities.We retrospectively analyzed 2,847 registered in Consecutive Cooperative Osteosarcoma Study Group database extremities, treated 1980 2010. Intended treatment included pre- postoperative chemotherapy surgery. Univariable multivariable survival analyses were performed for all then differentiated adult...
Ribosome profiling revealed widespread translational activity at upstream open reading frames (uORFs) and validated uORF-mediated control as a commonly repressive mechanism of gene expression. Translational activation proto-oncogenes through loss-of-uORF mutations has been demonstrated, yet systematic search for cancer-associated genetic alterations in uORFs is lacking. Here, we applied PCR-based, multiplex identifier-tagged deep sequencing approach to screen 404 uORF translation initiation...
The relatively low incidence and often atypical clinical presentation of soft-tissue sarcomas (STS) impedes early adequate diagnosis. Patients may report on recently enlarged swellings, infrequently complain painful lesions, or even have no symptoms at all.A thorough diagnostic work-up is essential in order to distinguish between benign tumours STSs. Patient history, features radiological findings all help assessing the underlying pathology. 'Worrying' such as recent increase size, deep...
Fritsche‐Guenther R, Noske A, Ungethüm U, Kuban R‐J, Schlag PM, Tunn P‐U, Karle J, Krenn V, Dietel M & Sers C (2010) Histopathology 57, 836–850 De novo expression of EphA2 in osteosarcoma modulates activation the mitogenic signalling pathway Aims: In patients development metastases, often to lungs, is most frequent cause death. The aim this study was elucidate molecular mechanisms governing and dissemination and, thereby, identify possible novel drug targets for improved treatment....
<b><i>Objective:</i></b> Epithelioid sarcoma (ES) presents unique clinical features in comparison to other subtypes. Data regarding the benefits of chemotherapy are very limited. Combination regimens using gemcitabine and docetaxel (Gem/Doce) have proven be effective, especially uterine nonuterine leiomyosarcoma. Yet, there is no available data on efficacy Gem/Doce ES. <b><i>Methods:</i></b> A retrospective analysis three participating...
Background. Surgical treatment of malignant pelvic bone tumors can be very challenging. The objective this retrospective study was to evaluate the oncological as well clinical and functional outcome after limb salvage surgery biological reconstruction. Methods. files 27 patients with tumors, who underwent surgical resection at our department between 2000 2011, were retrospectively analyzed (9 Ewing's sarcoma, 8 chondrosarcoma, 4 osteosarcoma, 1 synovial fibrous histiocytoma, carcinoma...
Abstract Background Isolated limb perfusion (ILP) is an effective salvage strategy in patients with advanced soft tissue sarcoma (STS) where surgery alone would result significant functional morbidity or mandate amputation. Most previous reports of undergoing ILP focus on rates rather than local and distant relapse rates. Here, we report the oncological outcome treated by surgery. Methods Data were retrieved from prospective databases two centers following similar techniques surgical...
The aim of the study is to assess effect perioperative chemotherapy (CTX) in patients with grade II-III extremity soft tissue sarcoma (eSTS) on overall survival (OS) and evaluate whether PERSARC prediction tool could identify eSTS more likely benefit from CTX.Patients (18-70 years) primary high-grade surgically treated curative intent were included retrospective cohort study. any CTX anthracycline + ifosfamide (AI)-based OS was investigated three PERSARC-risk groups (high/intermediate/low)....
To review the long term clinical outcomes in treatment of osteoid osteoma (OO) using radiofrequency ablation (RFA).Our retrospective study included 59 patients who were treated period from April 2001 to December 2012 due a symptomatic OO RFA. Here, occurrence complications and postoperative recurrence, as well patient satisfaction examined. Patients was assessed by means telephone interview with visual analogue scale (VAS).Mean follow-up 50 months (2 - 116 months). The average size nidus 6...