A5081981029- Cutaneous Melanoma Detection and Management
- Sarcoma Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Melanoma and MAPK Pathways
- Gastrointestinal Tumor Research and Treatment
- Neurofibromatosis and Schwannoma Cases
- Nonmelanoma Skin Cancer Studies
- Esophageal Cancer Research and Treatment
- Thyroid Cancer Diagnosis and Treatment
- Metastasis and carcinoma case studies
- Soft tissue tumor case studies
- Neuroendocrine Tumor Research Advances
- Vascular Tumors and Angiosarcomas
- Cancer Immunotherapy and Biomarkers
- Gastrointestinal disorders and treatments
- Parathyroid Disorders and Treatments
- Esophageal and GI Pathology
- Immunotherapy and Immune Responses
- S100 Proteins and Annexins
- Head and Neck Anomalies
- Cardiac tumors and thrombi
- Helicobacter pylori-related gastroenterology studies
- Reconstructive Surgery and Microvascular Techniques
- Genetic Syndromes and Imprinting
- Multiple and Secondary Primary Cancers
Radboud University Medical Center
2015-2025
University Medical Center
2014-2025
Radboud University Nijmegen
2015-2025
Leiden University
2022
Erasmus MC Cancer Institute
2020-2021
Leiden University Medical Center
2012
University of Amsterdam
2000
Neoadjuvant chemoradiotherapy before surgery can improve survival in patients with potentially curable esophageal cancer, but not all respond. Fluorodeoxyglucose positron emission tomography (FDG-PET) has been proposed to identify nonresponders early during neoadjuvant chemoradiotherapy. The aim of the present study was determine whether FDG-PET could differentiate between responding and nonresponding tumors course chemoradiotherapy.This clinical trial comprised serial 14 days after start...
4004 Background: Based on encouraging results of a phase II study we initiated III comparing preoperative chemoradiotherapy (CRT) followed by surgery versus alone in patients (pts) with esophageal or esophagogastric junction cancer. Methods: Pts resectable (T2-3N0-1M0) tumors received CRT consisting weekly administrations paclitaxel 50 mg/m2 and carboplatin AUC = 2 for 5 weeks concurrent radiotherapy (41.4 Gy 23 fractions, days per week) alone. Stratification parameters included performance...
To identify the optimal surgical strategy for multiple endocrine neoplasia type 1 (MEN1)-related primary hyperparathyroidism (pHPT). describe course of postoperative hypoparathyroidism and to assess whether genotype is associated with persistent/recurrent pHPT.Surgery preferred treatment in MEN1-related pHPT, but procedure choice still uncertain.This retrospective cohort study was performed at Departments Endocrinology University Medical Centers Utrecht Nijmegen, Netherlands. Patients were...
Recent reports suggest the limited efficacy of immune checkpoints inhibitors in advanced acral melanoma (AM). This study aims to investigate clinical outcomes checkpoint patients with stage III and IV AM compare them cutaneous (CM).We included CM treated first-line anti-programmed cell death (PD)-1 monotherapy or ipilimumab-nivolumab registered prospective nationwide Dutch Melanoma Treatment Registry. Objective response rates, progression-free survival (PFS) overall (OS) were calculated. A...
Previous studies demonstrated limited efficacy of immune checkpoint inhibitors in unresectable acral melanoma (AM); it remains unclear how this translates to the adjuvant setting. This study investigates clinical outcomes compared cutaneous (CM) patients treated with anti-PD-1 after complete resection. All stages III-IV AM and CM receiving resection between 2018 2022 were included from prospective nationwide Dutch Melanoma Treatment Registry. We analyzed recurrence-free survival (RFS),...
Malignant peripheral nerve sheath tumours (MPNSTs) have high local recurrence (LR) rates. Literature varies on LR risk factors and treatment. This study aimed to elucidate treatment options for first second LRs (LR1 LR2) in a large multicentre cohort.
BackgroundLittle is known about outcomes of adjuvant-treated melanoma patients beyond the clinical trial setting. Since 2019, have been registered in DMTR, a population-based registry to monitor quality and safety care Netherlands. This study aims describe treatment patterns, relapse, toxicity rates setting.MethodsAnalyses were performed on included DMTR. Descriptive statistics used analyse patient-, characteristics. A baseline registration completeness analysis was performed, an eligibility...
The aim of the study is to assess effect perioperative chemotherapy (CTX) in patients with grade II-III extremity soft tissue sarcoma (eSTS) on overall survival (OS) and evaluate whether PERSARC prediction tool could identify eSTS more likely benefit from CTX.Patients (18-70 years) primary high-grade surgically treated curative intent were included retrospective cohort study. any CTX anthracycline + ifosfamide (AI)-based OS was investigated three PERSARC-risk groups (high/intermediate/low)....
Neoadjuvant imatinib therapy plays a crucial role in the management of gastrointestinal stromal tumors (GISTs), but its impact across various mutational profiles remains uncertain. The aim this study is to describe clinicopathological features and assess response surgical outcomes neoadjuvant GIST patients exhibiting diverse profiles. We conducted retrospective study, extracting data from Dutch Registry, including treated with imatinib. Response rate was primary outcome, secondary were time...
Background. A randomized trial was undertaken comparing the Western R1 resection with limited N1-level lymphadenectomy and Japanese R2 extended lymphadenectomy, including N2-level for curative of gastric cancer patients. After 389 patients were entered in trial, protocol deviations observed that reduced intended distinction between two types lymphadenectomy: noncompliance, i.e., no substantiation by nodal yields at indicated stations, contamination, extension outside allocated level...
Abstract Purpose: Autosomal dominant hereditary diffuse gastric cancer (HDGC) is caused by germ-line E-cadherin (CDH1) gene mutations. Early detection of in carriers difficult because HDGC escapes endoscopic detection. We hypothesized that the glucose metabolism enhanced and this can be detected with [18F]fluoro-2-deoxy-d-glucose positron emission tomography (FDG-PET). Experimental Design Results: An asymptomatic twenty-eight year-old female was seen at our outpatient clinic a request for...
Medullary thyroid carcinoma (MTC) derives from the parafollicular C-cells of gland. Somatostatin receptors (SSTRs) are expressed in various neuroendocrine tumours including MTC. The aim this study was to evaluate SSTR2A as a prognostic factor for MTC, distribution expression within and compare between primary corresponding lymph node metastases. Patients who underwent surgery 1988 2014 MTC five tertiary referral centres Netherlands were included. In total, 114 patients metastases 34 analysed...
Nonsurgical management of patients with desmoid-type fibromatosis (DF) is increasing. This study tries to provide insight on type, usage, and outcome first-line nonsurgical strategies.From the Dutch Pathology Registry (PALGA), extra-abdominal or trunk/abdominal wall DF, diagnosed between 1993 2013, were identified. First-line treatment was analyzed. Best response (BR) using RECIST criteria from start treatment/surveillance until change last follow-up analyzed.Ninety-one 1141 identified had...
The efficacy of the classical treatment modalities surgery and radiotherapy in aggressive fibromatosis is presently disputed there a shift towards more conservative approach. aim present study to objectify tumor growth patients with extra-abdominal or abdominal wall fibromatosis, while adhering "watchful waiting" policy. Other objectives are investigate quality life identify factors associated growth, particular relation presence CTNNB1-gene mutation tumor.GRAFITI nationwide, multicenter,...
No studies extensively compared the young adults (YA, 18-39 years), middle-aged (40-69 and elderly (≥70 years) population with primary high-grade extremity soft tissue sarcoma (eSTS). This study aimed to determine whether known effect of age on overall survival (OS) disease progression can be explained by differences in tumour characteristics treatment protocol among YA, patients eSTS treated curative intent.In this retrospective multicentre study, inclusion criteria were 18 years older,...
Abstract Background In renal hyperparathyroidism, it remains unclear whether intraoperative parathyroid hormone (PTH) measurements can predict postoperative outcome and guide the extent of surgical exploration. Methods 42 parathyroidectomies for we analyzed predictive value Miami Criterion 50% PTH decrease. We used receiver operating characteristic (ROC) curves to find criterion with best diagnostic performance. also investigated whole assay improved accuracy. Results Twenty‐six operations...
Patients with palpable melanoma groin metastases have a poor prognosis. There is debate whether combined superficial and deep dissection (CGD) necessary or if (SGD) alone sufficient. The aim of this study was to analyze risk factors for pelvic nodal involvement in retrospective, multicenter cohort metastases. This could aid the development an algorithm selective surgery future. related 209 therapeutic CGDs from four tertiary centers Netherlands (1992–2013), selected based on complete...