A5032841187- Sarcoma Diagnosis and Treatment
- Venous Thromboembolism Diagnosis and Management
- Vascular Tumors and Angiosarcomas
- Colorectal Cancer Treatments and Studies
- Gastric Cancer Management and Outcomes
- Soft tissue tumor case studies
- Gastrointestinal Tumor Research and Treatment
- Neurofibromatosis and Schwannoma Cases
- Musculoskeletal synovial abnormalities and treatments
- Esophageal Cancer Research and Treatment
- Colorectal and Anal Carcinomas
- Chronic Lymphocytic Leukemia Research
- Renal cell carcinoma treatment
- Reliability and Agreement in Measurement
- Bone Tumor Diagnosis and Treatments
- Diet and metabolism studies
- Plant and Fungal Interactions Research
- Cancer and Skin Lesions
- Frailty in Older Adults
- Delphi Technique in Research
- Gastrointestinal disorders and treatments
- Blood Coagulation and Thrombosis Mechanisms
- Genetic factors in colorectal cancer
- Cardiac Imaging and Diagnostics
- Economic and Financial Impacts of Cancer
Reinier de Graaf Hospital
2023-2024
Leiden University Medical Center
2015-2022
Leiden University
2014-2020
Groene Hart Ziekenhuis
2012
Background and purpose — Tenosynovial giant cell tumors (TGCT) are rare, benign tumors, arising in synovial lining of joints, tendon sheaths, or bursae. 2 types distinguished: localized, either digits extremity, diffuse lesions. Current TGCT incidence is based on 1 single US-county study 1980, with an 9 per million person-years localized (including digits) TGCT, respectively. We aim to determine nationwide worldwide rates (IR) affecting digits, localized-extremity diffuse-type TGCT.Material...
Recently, the phase III PALETTE study introduced pazopanib (Votrient®) as treatment for adult patients with locally advanced or metastatic non-liposarcoma soft tissue sarcoma after prior doxorubicin and/or ifosfamide. Pneumothorax was reported adverse event in 8 of 246 treated (3.3%) that study. This case series presents incidence and clinic this complication Leiden University Medical Centre.Forty-three were which six (14.0%) developed a pneumothorax. These malignant peripheral nerve sheath...
Background and purpose — Giant cell tumors of bone (GCT-B) are rare, locally aggressive characterized by an abundance giant cells. Incidence studies for GCT-B rare. This is the first study using a fully automated 100% covering pathology database, nationwide Dutch Pathology Registry (17 million inhabitants), PALGA, to calculate incidence rates GCT-B. Patients methods From all excerpts were retrieved patients diagnosed with GCT-B, tenosynovium, soft tissue between January 1, 2009 December 31,...
Symptomatic gastrointestinal stromal tumours (GIST) are infrequent with an incidence of 12.7 per million inhabitants in the western population. We studied whether GIST has further increased between 2003 and 2012 assessed frequency mutations, risk groups, histological subtypes immunohistochemistry results. From PALGA, nationwide Dutch Pathology Registry, pathology excerpts from all patients a or GIST-like tumour were retrieved to calculate rates. Full reports resections 2011 study The 17.7...
Abstract Background Accurate detection of patients with minimal residual disease (MRD) after surgery for stage II colon cancer (CC) remains an urgent unmet clinical need to improve selection who might benefit form adjuvant chemotherapy (ACT). Presence circulating tumor DNA (ctDNA) is indicative MRD and has high predictive value recurrent disease. The MEDOCC-CrEATE trial investigates how many CC detectable ctDNA will accept ACT whether reduces the risk recurrence in these patients....
Abstract Background Doxorubicin based chemotherapy is standard first line treatment for patients with soft tissue sarcoma. Currently several options to improve survival after doxorubicin are being studied. This study reports on completing 6 cycles of containing treatment, which important when designing studies trying outcomes treatment. Methods A retrospective database analysis was performed 2045 from 12 EORTC sarcoma trials (inclusion period 1980–2012) receiving advanced in order establish...
Pazopanib is an oral tyrosine kinase inhibitor registered for metastatic renal cell carcinoma and soft tissue sarcoma. Liver toxicity a common side effect this class of agents. The current opinion that in case severe liver pazopanib should be interrupted restarted at lower dose after returning to Common Terminology Criteria Adverse Events (CTCAE) grade 1. After recurrence the it advised permanently stop pazopanib. We describe patient with YWHAE-FAM22 translocated endometrial stromal sarcoma...
Nonsurgical management of patients with desmoid-type fibromatosis (DF) is increasing. This study tries to provide insight on type, usage, and outcome first-line nonsurgical strategies.From the Dutch Pathology Registry (PALGA), extra-abdominal or trunk/abdominal wall DF, diagnosed between 1993 2013, were identified. First-line treatment was analyzed. Best response (BR) using RECIST criteria from start treatment/surveillance until change last follow-up analyzed.Ninety-one 1141 identified had...
Home treatment of cancer-associated venous thromboembolism (VTE) is challenging due to the high risk adverse events. While home quite agreeable cancer patients, studies evaluating safety VTE in this setting are largely unavailable.This was an observational study patients with VTE. The main outcomes were proportion treated at (hospital discharge <24 h after diagnosis) and 3-month incidence VTE-related events (major bleeding, recurrent and/or suspected mortality) managed hospital versus home.A...
Abstract Background The effectiveness of second-line palliative chemotherapy in patients with recurrent/metastatic osteosarcoma is not well defined. Several small studies (6–19 patients) have reported on ifosfamide as treatment. In this study we report our single-center experience monotherapy treated for osteosarcoma. Methods A chart review was conducted all from 1978 until 2017. Until 1997 a 5 g/m2 regimen used, and onwards 9 used. Overall survival (OS) start the primary endpoint....
New treatment strategies have improved survival of metastatic colorectal cancer in trials. However, it is not clear whether older patients benefit from these novel therapies, as they are often included pivotal Therefore, we investigated patterns and overall over time with a population-based study. We identified 22.192 Dutch aged ≥70 years diagnosed synchronous between 2005 2020 the Netherlands Cancer Registry. Changes were assessed logistic regression models. Survival was by Cox proportional...
<h3>Importance</h3> Triplet chemotherapy with fluorouracil, folinic acid, oxaliplatin, and irinotecan plus bevacizumab (FOLFOXIRI-B) is an effective first-line treatment option for patients metastatic colorectal cancer (mCRC). However, the degree of implementation FOLFOXIRI-B in daily practice unknown. <h3>Objectives</h3> To evaluate current adoption rate mCRC investigate perspectives medical oncologists toward this option. <h3>Design, Setting, Participants</h3> This 1-week, multicenter,...
Recent developments in esophageal cancer treatment, including studies exploring active surveillance following chemoradiotherapy, have led to a need for clear terminology and definitions regarding different multimodal treatment options.
Treating older adults with chemotherapy remains a challenge, given their under-representation in clinical trials and the lack of robust treatment guidelines for this population. Moreover, patients, especially those frailty, have an increased risk developing chemotherapy-related toxicity, resulting decreased quality life (QoL), hospitalisations high healthcare costs. Phase II suggested that upfront dose reduction can reduce toxicity rates while maintaining efficacy, leading to fewer...
Desmoid-type fibromatosis is a rare, highly infiltrative, locally destructive neoplasm that does not metastasize, but recurs often after primary surgery. Activation of the Wnt/β-catenin pathway pathogenic mechanism, caused by an activating mutation in exon 3 CTNNB1 (85% sporadic patients). Radiotherapy frequent treatment modality with local control rate approximately 80%. In very rare cases, this may result development radiation-induced sarcoma. It unclear whether these sarcomas develop from...
Patients with osteosarcoma (OS) and Ewing sarcoma (ES) are considered to have a high venous thromboembolism (VTE) risk, although the exact incidence prognostic impact under-researched in general as well relevant age groups.To study of VTE major bleeding (MB) OS ES patients, subdivided children, Adolescents Young Adults (AYAs; aged 18-39) older adults.Retrospective single-center chart review 519 165 patients treated between 1980 2018. were followed from diagnosis until an outcome interest...
Agranulocytosis is a rare but serious side effect of imatinib in gastrointestinal stromal tumor (GIST) patients. Imatinib an inhibitor the proto-oncogene tyrosine kinase (c-kit) and first-line agent patients with locally advanced metastatic GIST. Little evidence available on management this adverse event, consensus-based guidelines are lacking. In article, we describe 4 agranulocytosis after starting imatinib. addition, overview literature concerning underlying mechanisms given, therapeutic...
Developments in esophageal cancer treatment have led to need for clear terminology and definitions.This Delphi consensus study (https://