Leontine E.A.M.M. Spierings
A5000314244- Colorectal Cancer Treatments and Studies
- Colorectal Cancer Surgical Treatments
- Cancer Treatment and Pharmacology
- Gastric Cancer Management and Outcomes
- Cancer Genomics and Diagnostics
- Genetic factors in colorectal cancer
- Cancer survivorship and care
- Cancer Risks and Factors
- Healthcare cost, quality, practices
- Anorectal Disease Treatments and Outcomes
- Synthesis and biological activity
- Advanced Breast Cancer Therapies
- Stoma care and complications
- Economic and Financial Impacts of Cancer
- Biomedical and Engineering Education
- Curcumin's Biomedical Applications
- Chronic Lymphocytic Leukemia Research
- Pancreatic and Hepatic Oncology Research
- Retinoids in leukemia and cellular processes
- Frailty in Older Adults
- Colorectal Cancer Screening and Detection
- Metabolism, Diabetes, and Cancer
- Estrogen and related hormone effects
- Cancer-related Molecular Pathways
Alrijne Ziekenhuis
2018-2025
Amsterdam UMC Location University of Amsterdam
2015
Abstract Background Accurate detection of patients with minimal residual disease (MRD) after surgery for stage II colon cancer (CC) remains an urgent unmet clinical need to improve selection who might benefit form adjuvant chemotherapy (ACT). Presence circulating tumor DNA (ctDNA) is indicative MRD and has high predictive value recurrent disease. The MEDOCC-CrEATE trial investigates how many CC detectable ctDNA will accept ACT whether reduces the risk recurrence in these patients....
BackgroundThe aim of this nationwide cohort study was to examine the course symptoms and trajectories health-related quality life (HR-QoL) psychological distress during follow-up identify vulnerable patients.MethodsPatients with pathological stage I–III colorectal cancer (CRC) between 2013 2018 were included. Baseline characteristics collected from Netherlands Cancer Registry, patients completed European Organisation for Research Treatment QLQ-C30/CR29, Hospital Anxiety Depression Scale low...
Tamoxifen is a prodrug that primarily metabolized into the pharmacologically active metabolite endoxifen and eventually inactive metabolites. The herb curcumin may increase exposure by affecting phase II metabolism. We compared tamoxifen in breast cancer patients with or without curcumin, addition of bio-enhancer piperine. (20–30mg per day (q.d.)) was either given alone, combined (1200 mg three times daily (t.i.d.)) +/− piperine (10 t.i.d.). primary endpoint this study difference geometric...
Abstract Purpose Palbociclib has become the standard of care for estrogen receptor-positive (ER+), human epidermal growth factor receptor 2 negative (HER2-) metastatic breast cancer, but real-world evidence in older women remains scarce. Therefore, we investigated tolerability palbociclib with cancer. Methods Consecutive aged ≥ 70 ER+/HER2- treated any treatment line six hospitals, were included. Primary endpoint was grade 3 palbociclib-related toxicity. Predictors toxicity identified using...
PURPOSE The development of subcutaneous (SC) formulations for monoclonal antibodies (mAbs), as an alternative to conventional intravenous (IV) infusion, represents a shift in health care delivery. relative environmental impact these two administration methods is not well understood. Minimizing the footprint crucial due its substantial contribution greenhouse gas (GHG) emissions. This study compared carbon SC and IV using pertuzumab/trastuzumab case example. METHODS A Life Cycle Assessment...
Bowel dysfunction after rectal cancer surgery is common, with some experiencing low anterior resection syndrome (LARS) common surgery. This study examined if transanal total mesorectal excision (TaTME) has a similar risk of LARS and altered quality life (QoL) as patients who undergo (LAR).Patients underwent TaTME or traditionally approached in prospective colorectal cohort (2014-2019) were propensity score matched 1 : ratio. QoL scores assessed before primary endpoint major at 12 months...
The RECOURSE trial demonstrated a modest benefit in overall survival (OS) for trifluridine/tipiracil (FTD/TPI) versus placebo pretreated metastatic colorectal cancer (mCRC) patients. Unfortunately, quality of life (QoL) was not assessed. We evaluated QoL and patients treated with FTD/TPI daily practice.QUALITAS is substudy the Prospective Dutch CRC cohort (PLCRC). From 150 mCRC FTD/TPI, (EORTC QLQ-C30 QLQ-CR29) assessed monthly from study entry, linked to clinical data Netherlands Cancer...
New treatment strategies have improved survival of metastatic colorectal cancer in trials. However, it is not clear whether older patients benefit from these novel therapies, as they are often included pivotal Therefore, we investigated patterns and overall over time with a population-based study. We identified 22.192 Dutch aged ≥70 years diagnosed synchronous between 2005 2020 the Netherlands Cancer Registry. Changes were assessed logistic regression models. Survival was by Cox proportional...
<h3>Importance</h3> Triplet chemotherapy with fluorouracil, folinic acid, oxaliplatin, and irinotecan plus bevacizumab (FOLFOXIRI-B) is an effective first-line treatment option for patients metastatic colorectal cancer (mCRC). However, the degree of implementation FOLFOXIRI-B in daily practice unknown. <h3>Objectives</h3> To evaluate current adoption rate mCRC investigate perspectives medical oncologists toward this option. <h3>Design, Setting, Participants</h3> This 1-week, multicenter,...
The oral fluoropyrimidine S-1 has shown comparable efficacy to capecitabine in Asian and some Western studies on metastatic colorectal cancer. is associated with a lower incidence of hand-foot syndrome (HFS) cardiac toxicity. We assessed the long-term tolerability patients who discontinued for reasons HFS or Patients cancer switched from S-1, given as monotherapy combination other agents, were identified Dutch prospective cohort study (2016-2021). severity HFS, cardiotoxicity toxicities...
2572 Background: Tamoxifen is extensively used as endocrine therapy for breast cancer. It a prodrug that primarily metabolized by CYP2D6 and CYP3A4, particular into endoxifen. In daily practice, the herb curcumin widely among patients (pts) because of its presumed anti-tumor effects. Preclinical studies show effects on phase I II drug metabolism, leading to altered plasma levels. We hypothesized increases endoxifen exposure affecting metabolism. Therefore, we performed randomized, 3-phase,...