A5035401898- Cancer survivorship and care
- Childhood Cancer Survivors' Quality of Life
- Breast Cancer Treatment Studies
- Genomics and Rare Diseases
- Advanced Breast Cancer Therapies
- COVID-19 and healthcare impacts
- Family Support in Illness
- Cancer Genomics and Diagnostics
- Cancer Treatment and Pharmacology
- Palliative Care and End-of-Life Issues
- Ethics in Clinical Research
- BRCA gene mutations in cancer
- Acute Lymphoblastic Leukemia research
- Cancer-related cognitive impairment studies
- Breast Implant and Reconstruction
- Biomedical Ethics and Regulation
- Global Cancer Incidence and Screening
- Cancer Diagnosis and Treatment
- Ethics in medical practice
- Adolescent and Pediatric Healthcare
- Patient-Provider Communication in Healthcare
- Economic and Financial Impacts of Cancer
- Healthcare Operations and Scheduling Optimization
- Multiple and Secondary Primary Cancers
- Healthcare Policy and Management
University Medical Center Utrecht
2016-2025
Utrecht University
2018-2025
Cancer Genomics Centre
2018-2025
The Netherlands Cancer Institute
2019
Heidelberg University
2019
University Hospital Heidelberg
2019
Elisabeth-TweeSteden Ziekenhuis
1982
Abstract Background The coronavirus disease 2019 (COVID-19) pandemic (officially declared on the March 11, 2020), and resulting measures, are impacting daily life medical management of breast cancer patients survivors. We evaluated to what extent these changes have affected quality life, physical, psychosocial well-being previously or currently being treated for cancer. Methods This study was conducted within a prospective, multicenter cohort survivors (Utrecht Multiple BREast intervention...
Abstract Background Despite growing (inter)national awareness and appreciation, age‐specific care is still not always self‐evident accepted as standard of for adolescent young adult (AYA) cancer patients. It unknown whether long‐term AYA survivors have missed care, if so, which it regarding topics. Methods The Netherlands Cancer Registry (NCR) identified all (aged 18–39 years at initial diagnosis, 5–20 past diagnosis) in the Netherlands, who were invited to participate a population‐based,...
Abstract Physical exercise both during and after curative cancer treatment has been shown to reduce side effects. Evidence in the metastatic setting is scarce, interventions that improve health-related quality of life (HRQOL) are much needed for patients with breast (MBC). The multinational randomized controlled PREFERABLE-EFFECT trial assessed effects on fatigue HRQOL MBC. In total, 357 MBC a expectancy ≥6 months but without unstable bone metastases were recruited at eight study centers...
This study evaluates the risk of cardiovascular disease (CVD) following breast cancer, accounting for baseline CVD risk. Within EPIC-NL (Dutch part European Prospective Investigation into Nutrition and Cancer) cohort, 1103 women were diagnosed with cancer. For every cancer patient, 3–4 without (n = 4328) selected matched age, year, time since cohort enrollment. Based on factors at enrollment, 10-year was calculated categorized: low (< 10%), intermediate (10–20%), high (> 20%). Cox...
Adolescent and young adult (AYA) cancer patients, aged 15-39 years at primary diagnosis, form a distinct, understudied, underserved group in care. This study aimed to assess long-term trends incidence, survival, mortality of AYA patients within the Netherlands. Data on all malignant tumours diagnosed between 1990-2016 (n = 95,228) were obtained from Netherlands Cancer Registry. European age-standardised incidence rates with average annual percentage change (AAPC) statistics five-year...
Participation of Adolescents and Young Adults with cancer (AYAs: 18-39 years at time diagnosis) in patient-reported outcome studies is warranted given the limited knowledge (long-term) physical psychosocial health outcomes. We examined representativeness AYAs participating study, to observe impact various invitation methods on response rates reasons for non-participation.A population-based, cross-sectional cohort study was performed among long-term (5-20 years) AYA survivors. All...
Abstract Purpose To describe recall of fertility-related consultations and cryopreservation to examine reproductive goals reproduction post-treatment in long-term survivors adolescent young adult (AYA) (age, 18–39 years) cancer. Methods This study included n = 1457 male 2112 female ( M age 43–45 years; 5–22 years from diagnosis) who provided self-report. Clinical data were supplied by the Netherlands Cancer Registry. Results Most (72.7%) recalled 22.6% completed sperm cryopreservation....
The association between lymphedema of the arm and impaired health-related QoL (HR-QoL) has led to changes in clinical practice. However, data on breast (ie, edema) are lacking. We prospectively evaluated patient-reported prevalence determinants edema its effect HR-QoL pain.We included 836 patients undergoing breast-conserving surgery followed by radiotherapy October 2013 2016 (UMBRELLA cohort). Patient-reported edema, HR-QoL, pain were assessed means European Organisation for Research...
Adolescent and young adult (AYA) cancer survivors (18-39 years at diagnosis) often experience negative body changes such as scars, amputation, disfigurement. Understanding which factors influence image among AYA can improve age-specific care in the future. Therefore, we aim to examine prevalence, association of a with sociodemographic, clinical, psychosocial factors, (5-20 after diagnosis). A population-based cross-sectional cohort study was conducted registered within Netherlands Cancer...
Background: The COVID-19 pandemic, and the resulting measures, are impacting daily life medical management of patients with breast cancer. We evaluated to what extent these changes have affected quality life, physical psychosocial wellbeing (being) treated for Materials methods: This study was conducted within prospective Utrecht cohort Multiple BREast cancer intervention studies Long-term evaluation (UMBRELLA). Shortly after implementation extra questionnaires were sent 1595 participants,...
PURPOSE To evaluate the cost utility of a 9-month supervised exercise program for patients with metastatic breast cancer (mBC), compared control (usual care, supplemented general activity advice and an tracker). Evidence on cost-effectiveness mBC is essential implementation in clinical practice currently lacking. METHODS A cost-utility analysis was performed alongside multinational PREFERABLE-EFFECT randomized controlled trial, conducted 8 centers across Europe Australia. Patients (N = 357)...
Many women with breast cancer prematurely discontinue adjuvant endocrine therapy, leading to increased mortality. We performed a cross-sectional survey (n = 456) within the Dutch UMBRELLA-cohort gain insight into prevalence of side-effects and its association premature discontinuation. Almost all current therapy users experienced (92.7 %), most frequent were vasomotor- musculoskeletal symptoms. The reported reason for discontinuation was (88.1 %). Former treatment chemotherapy associated...
As the prognosis for adolescents and young adults (AYAs) with breast cancer has improved, long-term health-related quality of life (HRQoL) become increasingly important. This study aimed to analyze HRQoL AYA survivors compared an age-matched normative population identify factors associated HRQoL. Secondary analyses were conducted using data from SURVAYA study. The European Organization Research Treatment Cancer Quality Life Questionnaire Core-30 (EORTC QLQ-C30) was used assess Mann-Whitney U...
Health apps are increasingly being used in clinical care and may hold significant theoretical potential. However, they often implemented before any research has been done to confirm actual benefits for patients, physicians, researchers.This study aimed explore experiences of patients health providers with the use a supportive breast cancer app during first 6 months following diagnosis, terms practice purposes.Between June 2013 April 2014, all ages were invited shortly after diagnosis app,...
<h3>Background</h3> With increasing survival rates of adolescents and young adults (AYAs) with breast cancer, health-related quality life (HRQoL) becomes more important. An important aspect HRQoL is sexual QoL. This study examined long-term QoL AYA cancer survivors, compared scores that other identified factors associated survivors. <h3>Materials methods</h3> Data the SURVAYA were utilized for secondary analyses. Sexual was assessed using European Organization Research Treatment Cancer...
•Oncologists treat most eTNBC patients with chemotherapy due to a lack of implemented prognostic and predictive biomarkers.•We studied cohort systemic treatment-naïve young women node-negative 20 years median follow-up.•LVI (HR 2.35), fibrotic focus 1.61) sTILs 0.75 per 10% increment) had independent value for BCSS.•The presence LVI <30% identified an ultra-high risk recurrence or death.•De-escalation trials should consider the exclusion when is present. BackgroundIn absence biomarkers,...
Abstract The understanding and treatment of sexual health problems, impaired body image, other non‐life threatening but burdensome symptoms women with metastatic breast cancer (mBC) is still insufficient. We studied the factors associated such investigated whether these problems could be alleviated by a structured exercise intervention. In multinational PREFERABLE‐EFFECT study, 355 mBC were randomly assigned to usual care ( n = 178) or 9‐month supervised program 177). Breast cancer‐specific...
Ever since genetic testing is possible for specific mutations, ethical debate has sparked on the question of whether professionals have a duty to warn not only patients but also their relatives that might be at risk hereditary diseases. As next-generation sequencing (NGS) swiftly finds its way into clinical practice, who responsible conveying unsolicited findings family members becomes increasingly urgent. Traditionally, there strong emphasis duties professional in this debate. But what role...
Next-generation sequencing (NGS) can be used to generate information about a patient’s tumour and personal genome. This powerful diagnostic tool provides solicited unsolicited hereditary genetic (risk) that could have consequences for cancer patients their quality of life. A well-defined approach returning appropriate risk is needed in personalized care. qualitative design with semi-structured interviews was used. We conducted 24 Dutch different types cancer, both NGS-experienced...
To evaluate the impact of chemotherapy on subjective cognitive functioning according to age in a large cohort breast cancer patients.Within UMBRELLA cohort, 715 patients with early-stage primary invasive (T1-3N0-1M0) were selected. Subjective function was assessed by means EORTC QLQ-C30 up 24 months and compared between treated without chemotherapy, for three different strata (355 < 55 years, 240 aged 55-65 120 > 65 years). Differences non-chemotherapy at time points linear mixed-effect...
Abstract Purpose To identify factors associated with (perceived) access to health care among (ex-)breast cancer patients during the COVID-19 pandemic. Methods Cross-sectional study within a large prospective, multicenter cohort of patients, i.e., UMBRELLA. All participants enrolled in UMBRELLA between October 2013 and April 2020 were sent COVID-19-specific survey, including Hospital Anxiety Depression Scale (HADS) questionnaire. Results In total, 1051 (66.0%) completed survey. During...
Abstract INTRODUCTION: Patients with metastatic breast cancer (mBC) often experience cancer- and treatment-related side effects that can impair daily life activities health-related quality of (HRQoL). Interventions are needed improve HRQoL by alleviating fatigue other during palliative BC treatment. Recent evidence-based international guidelines (ASCO, ACSM) recommend exercise for patients adjuvant treatment reducing effects. However, evidence the effectiveness in mBC is scarce. The...