A5016548543- Breast Cancer Treatment Studies
- Cancer-related Molecular Pathways
- Cancer survivorship and care
- COVID-19 and healthcare impacts
- Global Cancer Incidence and Screening
- Breast Lesions and Carcinomas
- Blood groups and transfusion
- Erythrocyte Function and Pathophysiology
- Cancer Treatment and Pharmacology
- RNA modifications and cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Breast Implant and Reconstruction
- Palliative Care and End-of-Life Issues
- Cancer Diagnosis and Treatment
- Cancer-related cognitive impairment studies
- Complement system in diseases
- Metastasis and carcinoma case studies
- Advanced Breast Cancer Therapies
- Medical Imaging and Pathology Studies
- Genetic factors in colorectal cancer
- Hematopoietic Stem Cell Transplantation
- Brain Metastases and Treatment
- Economic and Financial Impacts of Cancer
- Chronic Myeloid Leukemia Treatments
- Lung Cancer Research Studies
University Medical Center Utrecht
2019-2024
Sanquin
2017-2023
Utrecht University
2021-2022
Cancer Genomics Centre
2022
University of Amsterdam
1993-2019
Amsterdam UMC Location University of Amsterdam
1993-2019
Walter and Eliza Hall Institute of Medical Research
2017
University of Pennsylvania
1996-2010
Institute of Cancer Research
2010
University of Nottingham
2010
Abstract Immunohistochemical detection of intranuclear p53 gene product may indicate mutation the suppressor on chromosome 17p. We used six commercially available antibodies for immunohistochemistry 19 archival colorectal neoplasms and compared results with status 17p allelic deletion status. By Friedman's ranking analysis, use mouse monoclonal antibody DO7 Target Unmasking Fluid (TUF) antigen retrieval was most sensitive specific procedure ( P <0·0001). Six 7 cases high expression (p53...
Abstract Background The coronavirus disease 2019 (COVID-19) pandemic (officially declared on the March 11, 2020), and resulting measures, are impacting daily life medical management of breast cancer patients survivors. We evaluated to what extent these changes have affected quality life, physical, psychosocial well-being previously or currently being treated for cancer. Methods This study was conducted within a prospective, multicenter cohort survivors (Utrecht Multiple BREast intervention...
Low-grade serous and endometrioid ovarian cancers adult-type granulosa cell tumors are rare malignancies that show high estrogen receptor positivity. Recurrences of these subtypes cancer often treated with conventional chemotherapy, although response rates disappointing. To determine the overall rate combination therapy abemaciclib letrozole in patients receptor-positive cancers. The will provide a clinically meaningful therapeutic benefit, an >25%. This is phase II, international,...
Humoral immune responses are tailored to the invading pathogen through regulation of key transcription factors and their networks. This is critical establishing effective antibody-mediated responses, yet it unknown how B cells integrate pathogen-induced signals drive or suppress transcriptional programs specialized for each class pathogen. Here, we detail role factor c-Myb in regulating T-bet-mediated anti-viral program. Deletion mature significantly increased serum IgG2c CXCR3 expression by...
Mutations in the p53 tumor suppressor gene are frequently observed primary lung adenocarcinomas, suggesting that these mutations critical events malignant transformation of airway cells. These often associated with stabilization product, resulting accumulation protein. In this study, 70 formalin-fixed, paraffin-embedded adenocarcinomas resected for potential cure were examined overexpression. obtained from a series patients well-documented clinical histories, and all carcinomas had been...
Atypical alveolar hyperplasia (AAH) is a potential precursor lesion from which lung adenocarcinomas arise and may be good target for studying the early events of tumorigenesis. We have previously shown that AAHs are neoplastic epithelial proliferations often harbor activating mutations K-ras oncogene. In current study, we examined spectrum to determine frequency timing p53 alterations in analyzed 37 their paired overt neoplasms protein accumulation using monoclonal antibody DO7. DNA sequence...
Background: The COVID-19 pandemic, and the resulting measures, are impacting daily life medical management of patients with breast cancer. We evaluated to what extent these changes have affected quality life, physical psychosocial wellbeing (being) treated for Materials methods: This study was conducted within prospective Utrecht cohort Multiple BREast cancer intervention studies Long-term evaluation (UMBRELLA). Shortly after implementation extra questionnaires were sent 1595 participants,...
Gestational trophoblastic diseases (GTDs) are a group of pregnancy-related premalignant and malignant with generally favorable prognosis when treated adequately. Many different treatment protocols exist worldwide. To our knowledge, this is the first set global consensus-based guidelines for GTD. Four international organizations (European Organisation Treatment Trophoblastic Diseases, European Society Gynecologic Oncology, Cancer Intergroup, International Study Diseases) delegated 53 expert...
Long axial field-of-view (LAFOV) PET/CT scanners have been introduced recently [1, 2], which offer numerous advantages [3].One important advantage of using LAFOV for imaging 89 Zr-labelled monoclonal antibodies (mAbs), i.e., immunoPET, is the substantial increase in sensitivity compared with standard (SAFOV) systems, may lead to a remarkable image quality improvement.This first study showcases such improvement immunoPET Biograph Vision Quadra™ (VQ) (Siemens Healthineers, Knoxville, TN,...
AIM: To evaluate similarities and differences between gastric stump cancer conventional carcinoma in the non-operated stomach. METHODS: 26 carcinomas were compared with 24 stomach cancers. Stage, histological type, demographics comparable two groups. Expression of p53 p21-Waf1/Cip1 was evaluated by immunohistochemical staining. Helicobacter pylori infection examining haematoxylin-eosin stained slides immunohistochemistry. Epstein-Barr virus RNA situ hybridisation. RESULTS: similar both...
Donor lymphocyte infusion (DLI) results in complete cytogenetic remission (CCR) of relapsed chronic-phase chronic myeloid leukemia (CML-CP) after allogeneic stem cell transplantation (SCT) up to 80% patients. The main complication DLI is graft-versus-host disease (GVHD). Decreasing the dose associated with less GVHD but also a longer interval between treatment and CCR. We postulated that combining alpha-interferon (alpha-IFN) would enable us decrease DLI, thereby limiting GVHD, at same time...
To evaluate the impact of chemotherapy on subjective cognitive functioning according to age in a large cohort breast cancer patients.Within UMBRELLA cohort, 715 patients with early-stage primary invasive (T1-3N0-1M0) were selected. Subjective function was assessed by means EORTC QLQ-C30 up 24 months and compared between treated without chemotherapy, for three different strata (355 < 55 years, 240 aged 55-65 120 > 65 years). Differences non-chemotherapy at time points linear mixed-effect...
Immunohistochemistry (IHC) for intranuclear p53 gene product is a simple, routine alternative to molecular genetic analysis of the gene. Several methods antigen enhancement are currently in use IHC. This study evaluates effect extreme p53, using monoclonal antibody (DO7) and polyclonal (CM1). The cases studied were five colorectal carcinomas, two specimens normal mucosa, four carcinomas with alterations which expected preclude expression, namely mutation STOP codon detected by denaturing...
Patient management of invasive breast cancer (IBC) is to a large extent based on hormone- and HER2-receptor assessment. High-quality, reliable receptor assessment key importance as false results may lead under- or overtreatment patients. Surveillance case-mix adjusted positivity rates has been suggested tool identify laboratories with insufficient testing assays, this covers the whole process enables benchmark their against other laboratories. We studied laboratory-specific variation in HER2...
We observed a clustering of cholangiocarcinoma in part West Virginia. analyzed the frequency and type alterations p53 tumor-suppressor gene K-ras oncogene to determine whether cholangiocarcinomas from this high-incidence area differ other at molecular level. studied 12 carcinomas patients (West Virginia group), 15 nearby states (non-West group). Over-expression product, accompanying most mutations gene, was determined by immunohistochemistry. sequence analysis exons 5, 6, 7, 8...
Immunohistochemistry (IHC) for intranuclear p53 gene product is a simple, routine alternative to molecular genetic analysis of the gene. Several methods antigen enhancement are currently in use IHC. This study evaluates effect extreme p53, using monoclonal antibody (DO7) and polyclonal (CM1). The cases studied were five colorectal carcinomas, two specimens normal mucosa, four carcinomas with alterations which expected preclude expression, namely mutation STOP codon detected by denaturing...
Abstract Purpose To evaluate symptoms of late radiation toxicity, side effects, and quality life in breast cancer patients treated with hyperbaric oxygen therapy (HBOT). Methods For this cohort study HBOT 5 Dutch facilities were eligible for inclusion. Breast toxicity ≥ 20 sessions from 2015 to 2019 included. arm symptoms, pain, assessed by means the EORTC QLQ-C30 -BR23 before, immediately after, 3 months after on a scale 0–100. Determinants associated persistent pain assessed. Results...
Abstract Purpose To identify factors associated with (perceived) access to health care among (ex-)breast cancer patients during the COVID-19 pandemic. Methods Cross-sectional study within a large prospective, multicenter cohort of patients, i.e., UMBRELLA. All participants enrolled in UMBRELLA between October 2013 and April 2020 were sent COVID-19-specific survey, including Hospital Anxiety Depression Scale (HADS) questionnaire. Results In total, 1051 (66.0%) completed survey. During...