A5001603562- Lymphoma Diagnosis and Treatment
- Parathyroid Disorders and Treatments
- Oral and Maxillofacial Pathology
- Organ Transplantation Techniques and Outcomes
- Melanoma and MAPK Pathways
- Tumors and Oncological Cases
- Cancer Genomics and Diagnostics
- Antimicrobial Peptides and Activities
- Biomarkers in Disease Mechanisms
- MicroRNA in disease regulation
- Dermatological and Skeletal Disorders
- Cutaneous Melanoma Detection and Management
- Viral-associated cancers and disorders
- Signaling Pathways in Disease
- Cutaneous lymphoproliferative disorders research
- Bone health and treatments
- Genetic factors in colorectal cancer
- Liver Disease and Transplantation
- Nuclear Structure and Function
- Cancer Diagnosis and Treatment
- Bone and Dental Protein Studies
- Peptidase Inhibition and Analysis
- Vitamin K Research Studies
- NF-κB Signaling Pathways
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
Medical University of Graz
2014-2025
University of Graz
2005-2022
Research Institute of Molecular Pathology
2009
Université Paris-Est Créteil
2007
Mylan (Switzerland)
2007
Center for Clinical Research (United States)
2007
SOX9 has been previously shown to be involved in hepatocellular carcinoma (HCC) and other types of cancer. However, prognostic studies so far rather small cohorts or lack external validation experimental data. In this study, we firstly determined the histological expression pattern human HCC by immunohistochemistry (n = 84) evaluated its value. External publicly available datasets were used validate relevance 359) cancer including breast 3951), ovarian 1306), lung 1926) gastric 876)....
Machine perfusion (MP) is gaining importance in liver transplantation, the only cure for many end-stage diseases. Varieties of different MP protocols are available. Currently, various available, differing not temperature but also specific solution required. We aimed to investigate performance an HTK-based perfusate during sub-normothermic (SNMP) discarded human grafts compared that a UW-based solution. Twenty livers (rejected transplantation by all centers) were subjected ex-vivo SNMP at...
Allergic asthma is currently considered a chronic airway inflammatory disorder associated with the presence of activated CD4<sup>+</sup> Th2-type lymphocytes, eosinophils, and mast cells. Interestingly, therapeutic strategies based on immune deviation suppression have been shown to successfully attenuate development phenotype. In this investigation, we for first time used genetically modified (GM) plant, narrow leaf lupin (<i>Lupinus angustifolius L.</i>), expressing gene potential allergen...
Abstract Extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue (MALT) are associated with various infectious pathogens. We analyzed the presence Chlamydia psittaci, pneumoniae, and trachomatis DNA in 47 nongastrointestinal 14 gastrointestinal MALT lymphomas, 37 nonmalignant control samples, 27 autoimmune precursor lesions by polymerase chain reaction amplification direct sequencing. In 13 (28%) were positive for C psittaci compared 4 (11%) samples (P = .09). was detected at...
Metastasis is responsible for the majority of cancer‐related deaths. Particularly, challenging management metastatic cancer unknown primary site (CUP), whose tissue origin (TOO) remains undetermined even after extensive investigations and therapy rather unspecific poorly effective. Molecular approaches to identify most probable TOO CUPs can overcome some these issues. In this study, we applied a predetermined set 89 microRNAs (miRNAs) infer 53 cancers or uncertain origin. The miRNA...
Abstract Chemokine receptors mediate migration and activation of lymphocytes through binding their ligands. Recent studies have revealed important contributions chemokine to the development, progression, dissemination haematopoietic neoplasms. Because receptor expression profile in extragastric MALT lymphoma is unknown, we performed a comprehensive study on tissue samples parotid glands, glands affected by Sjögren syndrome, lymphoma, extranodal diffuse large B‐cell (eDLBCL) originating from...
Histiocytic sarcoma (HS) is a rare but highly aggressive disease. The cancer-specific survival of patients with HS short and only limited response to conventional chemotherapy or radiation therapy seen. Some data from single case reports have suggested efficacy for high-dose autologous/allogeneic stem cell transplantation.We report on 4 cases HS, demonstrate that different druggable receptors are expressed HS. Using immunohistochemistry, we detected the expression platelet-derived growth...
Abstract Background & Aims Mallory‐Denk bodies ( MDB s) and intracellular hyaline IHB are cytoplasmic inclusions found in a subset of hepatocellular carcinoma HCC ). s mainly composed the intermediate filament proteins keratin (K) 8 K18, cellular stress‐ adapter‐protein sequestosome 1/p62 (p62) ubiquitin, whereas consist p62 and/or ubiquitin. Of note, containing can serve as markers suppressed autophagy, which turn has been associated with poor prognosis. The aim this study was to...
Aims: Clusterin shares functional properties with small heat shock proteins. In contrast to other proteins, it is present in the extracellular space. Its expression altered various diseases. The aim was evaluate presence and distribution of clusterin liver diseases associated cholestasis, fibrosis hepatocellular carcinoma. Methods results: Tissue microarrays biopsy materials were used immunohistochemically carcinoma, primary sclerosing cholangitis, biliary cirrhosis, mechanical drug‐induced...
Spinophilin, a multifunctional intracellular scaffold protein, is reduced in certain types of cancer and regarded as novel putative tumour suppressor protein. However, the role spinophilin hepatocellular carcinoma (HCC) has never been explored before. In this study, we determined for first time expression pattern human HCC by immunohistochemistry quantitative reverse transcriptase–PCR analysis. addition, performed immunohistochemical analysis p53, p14ARF proliferation marker Ki-67....
Gallbladder cancer (GBC) is a rare neoplasia of the biliary tract with high mortality rates and poor prognosis. Signs symptoms GBC are not specific often arise at late stage disease. For this reason, diagnosis typically made when already in advanced stages, prognosis for survival less than 5 years 90% cases. Biomarkers to monitor disease progression novel therapeutic alternative targets these tumors strongly required. Commonly, dysregulated protein synthesis contributes carcinogenesis...
Aims Because the hedgehog signalling pathway plays a major role in many types of cancer and can nowadays be targeted by specific compounds, we aimed to investigate this squamous cell carcinoma head neck. Methods results Ninety‐eight treatment‐naive neck specimens were immunohistologically stained for SMO, GLI‐1, p53 p16 expression correlated with clinicopathological factors. Immunoreactivity SMO GLI‐1 was found 20 (20.4%) 52 (53.1%) cases tumours, respectively. (ρ = 0.258, P 0.010)...
BRAF mutations occur in up to 50% of melanomas. Mutations the gene directly influence patient's treatment because several inhibitors are available that only target BRAFV600 mutations. Herein, we describe two cases patients with metastatic melanomas, each carrying a 'nonstandard' mutation gene: BRAFK601E and BRAFG466E, respectively. The first patient was treated MEK inhibitor second one ipilimumab. However, not all result increased kinase activity, clinical data for mutations, such as those...
The influence of human prolactin (hPRL) on the development breast and other types cancer is well established. Little information, however, exists effects hPRL squamous cell carcinomas head neck (SCCHNs). In this study, we evaluated receptor (PRLR) expression in SCCHN lines assessed by immunohistochemistry 89 patients with SCCHNs. PRLR was correlated clinicopathological characteristics as clinical outcome. effect treatment tumour growth vitro. Immunoreactivity for observed 85 out (95%)...