A5024719106- Lymphoma Diagnosis and Treatment
- Nuclear Receptors and Signaling
- CAR-T cell therapy research
- Chronic Lymphocytic Leukemia Research
- Immune Cell Function and Interaction
- Viral-associated cancers and disorders
- Chemokine receptors and signaling
- Cancer-related molecular mechanisms research
- Bioactive Compounds and Antitumor Agents
- MicroRNA in disease regulation
- Circular RNAs in diseases
- NF-κB Signaling Pathways
- Cytokine Signaling Pathways and Interactions
- Epigenetics and DNA Methylation
- Monoclonal and Polyclonal Antibodies Research
- Cancer-related gene regulation
- Synthesis and Biological Evaluation
- Macrophage Migration Inhibitory Factor
- Multiple Myeloma Research and Treatments
- Cancer, Hypoxia, and Metabolism
- CNS Lymphoma Diagnosis and Treatment
- Signaling Pathways in Disease
- Cancer Genomics and Diagnostics
- Glioma Diagnosis and Treatment
- Inflammatory Biomarkers in Disease Prognosis
Medical University of Graz
2016-2025
BioTechMed-Graz
2021
Center For Biomarker Research In Medicine
2018
Paracelsus Medical University
2015
The University of Texas MD Anderson Cancer Center
2015
University of Graz
2015
LMU Klinikum
2008
Ludwig-Maximilians-Universität München
2008
Houston Medical Center
2004
Spring Branch Medical Center
2004
Cancer cells voraciously consume nutrients to support their growth, exposing metabolic vulnerabilities that can be therapeutically exploited. Here, we show in hepatocellular carcinoma (HCC) cells, xenografts, and patient-derived organoids fasting improves sorafenib efficacy acts synergistically sensitize sorafenib-resistant HCC. Mechanistically, noncanonically as an inhibitor of mitochondrial respiration, causing resistant depend on glycolysis for survival. Fasting, through reduction glucose...
Recent transcriptomic-based analysis of diffuse large B cell lymphoma (DLBCL) has highlighted the clinical relevance lymph node (LN) fibroblast and tumor-infiltrating lymphocyte (TIL) signatures within tumor microenvironment (TME). However, immunomodulatory role fibroblasts in remains unclear. Here, by studying human mouse DLBCL-LNs, we identify presence an aberrantly remodeled fibroblastic reticular (FRC) network, expressing elevated activated protein (FAP). RNA-sequencing analyses reveal...
Activity-guided fractionation of a petroleum ether-soluble extract the roots Onosma paniculata, which has been shown to affect cell cycle and induce apoptosis in melanoma cells, led isolation several shikonin derivatives, namely, β-hydroxyisovalerylshikonin (1), acetylshikonin (2), dimethylacrylshikonin (3), mixture α-methylbutyrylshikonin isovalerylshikonin (4+5). All compounds exhibited strong cytotoxicity against eight cancer lines MRC-5 lung fibroblasts, with 3 found possess most potent...
Expression of miR‐96‐5p is frequently altered in various types cancer and the KRAS oncogene has been identified as one its potential targets. However, biological role expression colorectal (CRC) ability to predict clinical course patients have not investigated yet. In this study, we explored 80 CRC evaluated impact on outcome by Kaplan‐Meier curves multivariate Cox proportional models. vitro inhibition overexpression were performed cells effects cellular growth, anchorage‐independent...
Summary The International Prognostic Index ( IPI ) has been used for decades in diffuse large B‐cell lymphoma DLBCL ). A retrospective cancer registry analysis North America showed significantly improved results when an enhanced , the National Comprehensive Cancer Network NCCN )‐ was applied. This novel score puts more weight on age and high levels of lactate dehydrogenase LDH Nevertheless, it remains unclear if these can be extrapolated to general population. bi‐centre included 499...
Abstract Isocitrate dehydrogenases (IDH) convert isocitrate to alpha-ketoglutarate (α-KG). In cancer, mutant IDH1/2 reduces α-KG D2-hydroxyglutarate (D2-HG) disrupting α-KG-dependent dioxygenases. However, the physiological relevance of controlling interconversion D2‐HG into α‐KG, mediated by D2‐hydroxyglutarate dehydrogenase (D2HGDH), remains obscure. Here we show that wild-type D2HGDH elevates levels, influencing histone and DNA methylation, HIF1α hydroxylation. Conversely, mutants find in...
Purpose: miR-196b-5p has been previously implicated in malignant transformation; however, its role colorectal cancer not fully explored. In this study, we examine the clinical and biological relevance of miR-196b-5p, molecular pathways regulated by cancer.Experimental Design: expression was quantitated qRT-PCR 2 independent cohorts composed 292 patients with total, to explore biomarker potential. Transient stable gain- loss-of-function experiments were conducted a panel cell lines mice,...
Abstract The RNA-binding protein ALYREF (THOC4) is involved in transcriptional regulation and nuclear mRNA export, though its role molecular mode of action breast carcinogenesis are completely unknown. Here, we identified high expression as a factor for poor survival cancer patients. significantly influenced cellular growth, apoptosis mitochondrial energy metabolism cells well tumorigenesis orthotopic mouse models. Transcriptional profiling, phenocopy rescue experiments the short isoform...
High levels of C-reactive protein (CRP), an acute phase protein, proofed being associated with decreased clinical outcome in small-scale studies diffuse large B-cell lymphoma (DLBCL). The aim this study was to evaluate the prognostic impact pretreatment CRP on overall survival (OS) and disease-free (DFS) a bicentre DLBCL patients. Data from 477 patients, diagnosed treated between 2004 2013 at two Austrian centres, were evaluated retrospectively. influence other factors, including age, tumour...
Micro-RNAs (miRNAs) are short non-coding single-stranded RNA molecules regulating gene expression at the post-transcriptional level. miRNAs involved in cell development, differentiation, apoptosis, and proliferation. can either function as tumor suppressor genes or oncogenes various important pathways. The of specific has been identified to correlate with prognosis. For miRNA analysis real-time PCR on 81 samples was performed, including 63 diffuse large B-cell lymphoma (DLBCL, 15 germinal...
Febrile neutropenia (FN) after chemotherapy is a major cause of morbidity during cancer treatment. The performance metagenomic next-generation sequencing (mNGS) circulating cell-free deoxyribonucleic acid from plasma may be superior to blood culture (BC) diagnostics for identification causative pathogens. aim this study was validate mNGS (DISQVER test) the detection pathogens in hematologic patients with FN.We collected paired whole specimens central venous catheter and peripheral vein FN BC...
Aggressive B-cell lymphomas are the most common lymphoid malignancies in adults, with an increasing incidence. Diffuse large lymphoma (DLBCL) is prevalent and highly heterogeneous type, often exhibiting poor responses to standard immuno-chemotherapy. One third of patients experience primary refractory disease or relapse, particularly those high c-MYC BCL-2 expression levels, which drive aggressiveness resistance treatment. Therefore, development new therapies urgently needed. This study...
Abstract Tumor‐agnostic precision medicine (PM) strategies promise to support treatment decisions in relapsed/refractory blood cancer patients. Genomic‐based PM (gPM) and drug screening‐based functional (fPM) currently represent the most prominent methodologies. In this study, we report feasibility analysis of first 55 patients enrolled multicentric, randomized controlled EXALT‐2 trial (NCT04470947) comparing recommendations gPM, fPM, physicians' choice (PC) head head. 54 (98%), diagnostic...
Abstract Extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue (MALT) are associated with various infectious pathogens. We analyzed the presence Chlamydia psittaci, pneumoniae, and trachomatis DNA in 47 nongastrointestinal 14 gastrointestinal MALT lymphomas, 37 nonmalignant control samples, 27 autoimmune precursor lesions by polymerase chain reaction amplification direct sequencing. In 13 (28%) were positive for C psittaci compared 4 (11%) samples (P = .09). was detected at...
Background: Several serum parameters have been evaluated for adding prognostic value to clinical scoring systems in diffuse large B-cell lymphoma (DLBCL), but none of the reports used multivariate testing more than one parameter at a time. The goal this study was validate widely available their independent impact era National Comprehensive Cancer Network–International Prognostic Index (NCCN-IPI) score determine which were most useful. Patients and Methods: This retrospective bicenter...