A5037504150- Bioactive Compounds and Antitumor Agents
- Cancer therapeutics and mechanisms
- Synthesis of Organic Compounds
- Marine Sponges and Natural Products
- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Synthesis and biological activity
- Synthesis and Biological Evaluation
- Phytochemical compounds biological activities
- Essential Oils and Antimicrobial Activity
- Sesquiterpenes and Asteraceae Studies
- Phytochemicals and Antioxidant Activities
- Synthesis and Reactions of Organic Compounds
- Phenothiazines and Benzothiazines Synthesis and Activities
- Fungal Biology and Applications
- Seaweed-derived Bioactive Compounds
- X-ray Diffraction in Crystallography
- Synthesis of heterocyclic compounds
- Crystallization and Solubility Studies
- Ethnobotanical and Medicinal Plants Studies
- Medicinal plant effects and applications
- Phytochemistry and Bioactive Compounds
- Traditional and Medicinal Uses of Annonaceae
- Advances in Cucurbitaceae Research
- Phytochemical Studies and Bioactivities
University of Graz
2015-2024
Medical University of Graz
2020-2022
Pharmac
2014-2019
Universidad Nacional del Sur
2014
Activity-guided fractionation of a petroleum ether-soluble extract the roots Onosma paniculata, which has been shown to affect cell cycle and induce apoptosis in melanoma cells, led isolation several shikonin derivatives, namely, β-hydroxyisovalerylshikonin (1), acetylshikonin (2), dimethylacrylshikonin (3), mixture α-methylbutyrylshikonin isovalerylshikonin (4+5). All compounds exhibited strong cytotoxicity against eight cancer lines MRC-5 lung fibroblasts, with 3 found possess most potent...
// Qiaoli Zhao 1 , Andreana N. Assimopoulou 2 Sabine M. Klauck 3 Harilaos Damianakos 4 Ioanna Chinou Nadine Kretschmer 5 José-Luis Rios 6 Vassilios P. Papageorgiou Rudolf Bauer Thomas Efferth Department of Pharmaceutical Biology, Institute Pharmacy and Biochemistry, Johannes Gutenberg University, Mainz, Germany Chemical Engineering, Aristotle University Thessaloniki, Greece Working Group Cancer Genome Research, German Research Center (DKFZ) Consortium (DKTK), National for Tumor...
The phytochemical investigation of the n-hexane extract from callus and cell suspension culture Arnebia euchroma (Royle) Jonst. resulted in isolation nine isohexenylnaphthazarins: deoxyalkannin (1), alkannin (2), acetylalkannin (3), isobutyrylalkannin (4), β-hydroxyisovalerylalkannin (5), 2''-(S)-α-methylbutyrylalkannin (6), propionylalkannin (7), teracrylalkannin (8) acetylshikonin (9). Their structures were determined by MS NMR spectroscopy. Pigments 2–8 are isolated for first time vitro...
Overexpression and mutation of the epidermal growth factor receptor (EGFR) gene play a causal role in tumorigenesis resistance to treatment glioblastoma (GBM). EGFR inhibitors such as erlotinib are currently used for GBM; however, their efficacy has been limited due drug resistance. New strategies therefore urgently needed. Shikonin, natural naphthoquinone, induces both apoptosis necroptosis human glioma cells, but effectiveness erlotinib-shikonin combination well underlying molecular...
In the course of a screening program on seasonal phenol composition wild Mediterranean medicinal and aromatic plants, broadly used for culinary purposes, Foeniculum vulgare Mill. was focus present study. Hydroalcoholic extracts from fennel freeze-dried leaves, collected in different seasons along 2012 2013 years, were quali-quantitatively analyzed through LC/MS/MS techniques. Winter extract contained, beyond several hydroxycinnamoyl quinic acids flavonol glycosides, two chromone derivatives....
Human soft tissue sarcomas represent a rare group of malignant tumours that frequently exhibit chemotherapeutic resistance and increased metastatic potential following unsuccessful treatment. In this study, we investigated the effects costunolide dehydrocostus lactone, which have been isolated from <i>Saussurea lappa</i> using activity-guided isolation, on three sarcoma cell lines various origins. The proliferation, cycle distribution, apoptosis induction, ABC transporter expression were...
Soft tissue sarcomas (STS) represent a rare group of malignant tumors that frequently exhibit chemotherapeutic resistance and increased metastatic potential. Many studies have demonstrated the great potential plant-derived agents in treatment various entities. The present study investigates effects sesquiterpene lactones costunolide dehydrocostus lactone on cell cycle, MMP expression, invasive three human STS lines origins. Both compounds reduced proliferation time- dose-dependent manner....
New treatment options are needed for medullary thyroid carcinoma (MTC), a highly metastasizing neuroendocrine tumor that is resistant to standard radiotherapy and chemotherapy. We show the following shikonin derivatives inhibit cell proliferation viability of MTC line TT: acetylshikonin, β,β-dimethylacrylshikonin, petroleum ether extract roots Onosma paniculata containing several derivatives. The unsubstituted derivative was found be most effective compound with an IC50 1.1 µM. normal human...
Osteoarthritis (OA) is the most common joint disorder and characterized by degeneration of articular cartilage. To develop new therapeutic approaches, we investigated effect shikonin derivatives on inflammation, MMP expression, regulation MAPK signaling in human healthy (HC) OA chondrocytes (pCH-OA). Viability was analyzed using CellTiter-Glo® Assay. Inflammatory processes were a proteome profiler™ assay. Furthermore, effects protein expression analysis phosphorylation pattern corresponding...
Periploca sepium is traditionally used in Chinese medicine to treat particularly rheumatic disorders and as a tonic. Periplocin was found the most cytotoxic compound of its root bark induced death receptor mediated apoptosis liposarcoma cells. Sarcomas are rare type cancer with only few treatment options. The five-year survival rate advanced tumors low. In this study, we investigated effects periplocin two myxofibrosarcoma (MFS)cell lines, MUG-Myx2a MUG-Myx2b, which subclones same tumor...
Although chondrosarcoma is the second most common primary malignant bone tumor, treatment options are limited due to its extensive resistance a chemo- and radiation therapy. Since shikonin has shown potent anticancer activity in various types of cancer cells, it represents promising compound for development new therapeutic approach.The dose-relationships derivatives acetylshikonin cyclopropylshikonin on two human cell lines were measured using CellTiter-Glo®. The changes cycle presented by...
Despite much research in the last centuries, treatment of malignant melanoma is still challenging because its mostly unnoticeable metastatic spreading and aggressive growth rate. Therefore, discovery novel drug leads an important goal. In a previous study, we have isolated several shikonin derivatives from roots Onosma paniculata Bureau & Franchet (Boraginaceae) which evolved as promising anticancer candidates. β,β-Dimethylacrylshikonin (1) was most cytotoxic derivative exhibited strong...
Skin cancer is currently diagnosed as one in every three cancers. Melanoma, the most aggressive form of skin cancer, responsible for 79% deaths and incidence rising faster than any other solid tumor type. Previously, we have demonstrated that dimethylacrylshikonin (DMAS), isolated from roots Onosma paniculata (Boraginaceae), exhibited lowest IC50 values against different types out several shikonin derivatives. DMAS was especially cytotoxic towards melanoma cells led to apoptosis cell cycle...
Lichens are resilient organisms, known for their unique profiles of secondary metabolites and exhibiting antioxidative, antibacterial, cytotoxic effects. Analyzing the potential Lobaria scrobiculata, a bioassay-guided fractionation strategy yielded seven metabolites, with two these compounds, 2 3, cytotoxicity against HL-60 cells. In order to verify impact degradation on observed bioactivity, purity stability evaluation was conducted. The consistency results obtained by water-soluble...
Biphenyl neolignans such as honokiol and magnolol, which are the major active constituents of Asian medicinal plant Magnolia officinalis, known to exert a multitude pharmacological biological activities. Among these, cytotoxic tumor growth inhibitory activity against various tumour cell lines well-documented. To further elucidate effects derivatives, derivatizations were performed using tetrahydrohonokiol scaffold. The comprised introduction functional groups, e.g., nitro amino well...