A5077907318- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- MicroRNA in disease regulation
- RNA Research and Splicing
- Immune cells in cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer, Lipids, and Metabolism
- Immune Cell Function and Interaction
- Pancreatic and Hepatic Oncology Research
- Historical, Literary, and Cultural Studies
- Historical and Archaeological Studies
- Medieval European History and Architecture
- Ancient Mediterranean Archaeology and History
- Circular RNAs in diseases
- Cancer, Hypoxia, and Metabolism
- Art, Aesthetics, and Perception
- German Literature and Culture Studies
- Vagus Nerve Stimulation Research
- Chromosomal and Genetic Variations
- RNA regulation and disease
- CRISPR and Genetic Engineering
- Ferroptosis and cancer prognosis
Medical University of Graz
2018-2024
Oncode Institute
2024
The Netherlands Cancer Institute
2024
Abstract The RNA-binding protein ALYREF (THOC4) is involved in transcriptional regulation and nuclear mRNA export, though its role molecular mode of action breast carcinogenesis are completely unknown. Here, we identified high expression as a factor for poor survival cancer patients. significantly influenced cellular growth, apoptosis mitochondrial energy metabolism cells well tumorigenesis orthotopic mouse models. Transcriptional profiling, phenocopy rescue experiments the short isoform...
Abstract Tumor-specific CD8+ T cells are key effectors of antitumor immunity but often rendered dysfunctional in the tumor microenvironment. Immune-checkpoint blockade can restore T-cell function some patients; however, most do not respond to this therapy, despite infiltration their tumors. We here explored a CD8-targeted IL2 fusion molecule (CD8–IL2) selectively reactivate intratumoral patient-derived fragments. Treatment with CD8–IL2 broadly armed enhanced effector capacity, thereby...
Whether 2nd-line-chemotherapy (2LCTX) + best-supportive-care (BSC) benefits patients with advanced biliary tract cancer (aBTC) more than BSC alone is unclear. We therefore conducted a propensity-score-based comparative effectiveness analysis of overall survival (OS) outcomes in 80 metastatic, recurrent, or inoperable aBTC, whom 38 (48%) were treated 2LCTX and 42 (52%) alone. After median follow-up 14.8 months 49 deaths, the crude 6-, 12-, 18-month Kaplan-Meier OS estimates 77%, 53% 23%...
Introduction: The activity of butyrylcholinesterase (BChE) in blood reflects liver function and has recently been associated with systemic inflammatory response tumor cachexia. As these conditions have previously linked pancreatic cancer (PC), the purpose present study was to evaluate prognostic impact plasma BChE PC. Methods: Data from 574 consecutive PC patients, treated between 2004 2018 at a single academic center, evaluated. primary endpoint cancer-specific survival (CSS), analyzed by...
The advanced lung cancer inflammation index (ALI) was first introduced for prognosis prediction in patients and since then evaluated several other malignancies. However, pancreatic (PC) the ALI its prognostic utility were only investigated a comparably small specific cohort of locally PC treated with chemoradiotherapy.In our single-center study, we included 429 histologically verified who between 2003 2015 at academic institution. defined as body mass (BMI; kg/m2 ) × serum albumin levels...
Abstract Background Triple negative breast cancer (TNBC) is a particularly aggressive and difficult-to-treat subtype of that requires the development novel therapeutic strategies. To pave way for such developments it essential to characterize new molecular players in TNBC. MicroRNAs (miRNAs) constitute interesting candidates this regard as they are frequently deregulated contribute numerous aspects carcinogenesis. Methods results Here, we discovered miR-4649-5p, miRNA yet uncharacterized...
Pancreatic enzymes might play a pivotal role in the pathophysiology and prognosis of pancreatic cancer. The aim this study is to investigate lipase/amylase ratio (LAR), representing marker previously used differentiation pancreatitis, as potential prognostic Data from 157 surgically treated patients with ductal adenocarcinoma 351 metastatic disease were evaluated retrospectively. Cancer-specific survival (CSS) was considered endpoint study. After applying Kaplan-Meier curve analysis, uni-...
Biliary tract cancer is a major global health issue in cancer-related mortality. Therapeutic options are limited, and cisplatin-based treatment schedules represent the mainstay of first-line therapeutic strategies. Although gain survival by addition cisplatin to gemcitabine moderate, acquired resistance frequently leads failures with mechanisms that still poorly understood. Epithelial–mesenchymal transition (EMT) dynamic process changes shape, function, gene expression pattern biliary cells....
Biliary tract cancer is a deadly disease with limited therapeutic options. Ouabain well-known inhibitor of the pumping function Na+/K+-ATPase, though there evidence that low concentrations ouabain lead to reduction cell viability cells independent its inhibition Na+/K+-ATPase. Regarding impact on biliary cancer, no data currently available. Therefore, we aimed for first-time investigation as potential anti-neoplastic agent using comprehensive human in vitro models. We found has strong...
The microRNA-200 family has wide-ranging regulatory functions in cancer development and progression. Above all, it is strongly associated with the epithelial-to-mesenchymal transition (EMT), a process during which cells change their epithelial to mesenchymal phenotype acquire invasive characteristics. More recently, miR-200 members have also been reported impact immune evasion of by regulating expression immunoinhibitory checkpoints (ICs) like PD-L1. Therefore, we aimed comprehensively...
MicroRNAs (miRNAs) are crucial post-transcriptional regulators of gene expression, and their deregulation contributes to many aspects cancer development progression. Thus, miRNAs provide insight into oncogenic mechanisms represent promising targets for new therapeutic approaches. A type that is still in urgent need improved treatment options triple negative breast (TNBC). Therefore, we aimed characterize a novel miRNA with potential role TNBC. Based on previous study, selected miR-4646-5p,...
<div>Abstract<p>Tumor-specific CD8<sup>+</sup> T cells are key effectors of antitumor immunity but often rendered dysfunctional in the tumor microenvironment. Immune-checkpoint blockade can restore T-cell function some patients; however, most do not respond to this therapy, despite infiltration their tumors. We here explored a CD8-targeted IL2 fusion molecule (CD8–IL2) selectively reactivate intratumoral patient-derived fragments. Treatment with CD8–IL2 broadly armed...
<p>Response dynamics of intratumoral CD8<sup>+</sup> T cell states to CD8-IL2 and other IL2 conditions.</p>
<p>CD8-IL2-induced reinvigoration of intratumoral CD8<sup>+</sup> T cells in individual tumor samples.</p>
<p>Comparison of intratumoral T cells responding to CD8-IL2 and anti-PD 1.</p>
<p>Comparison of intratumoral T cells responding to CD8-IL2 and anti-PD 1.</p>
<p>Characterization of LCKi-induced effects.</p>