A5063203064- Cancer Genomics and Diagnostics
- Genetic factors in colorectal cancer
- Molecular Biology Techniques and Applications
- Ion channel regulation and function
- RNA modifications and cancer
- BRCA gene mutations in cancer
- Sarcoma Diagnosis and Treatment
- Ovarian cancer diagnosis and treatment
- Protease and Inhibitor Mechanisms
- Lung Cancer Treatments and Mutations
- Thyroid Cancer Diagnosis and Treatment
- Advanced Breast Cancer Therapies
- Cell Adhesion Molecules Research
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Cancer, Hypoxia, and Metabolism
- Breast Lesions and Carcinomas
- Receptor Mechanisms and Signaling
- Colorectal and Anal Carcinomas
- Endometrial and Cervical Cancer Treatments
- Cancer Cells and Metastasis
- PARP inhibition in cancer therapy
- Radiopharmaceutical Chemistry and Applications
- Peptidase Inhibition and Analysis
- Chronic Lymphocytic Leukemia Research
Medical University of Graz
2014-2025
Evotec (Germany)
2025
Universitätsklinik für Frauenheilkunde und Geburtshilfe
2018
Medical University of Vienna
2013-2016
Ordensklinikum Linz Barmherzige Schwestern
2016
Paracelsus Medical University
2016
Comprehensive Cancer Center Vienna
2016
Cancer Institute (WIA)
2016
Bundeswehrkrankenhaus
2016
University Hospital Heidelberg
2013
Despite the excellent prognosis of Fédération Internationale de Gynécologie et d'Obstétrique (FIGO) stage I, type I endometrial cancers, a substantial number patients experience recurrence and die from this disease. We analyzed value immunohistochemical L1CAM determination to predict clinical outcome.We conducted retrospective multicenter cohort study determine expression by immunohistochemistry in 1021 cancer specimens. The Kaplan-Meier method Cox proportional hazard model were applied for...
Mechanical interaction between cells – specifically distortion of tensional homeostasis-emerged as an important aspect breast cancer genesis and progression. We investigated the biophysical characteristics mechanosensitive ion channels (MSCs) in malignant MCF-7 cell line. MSCs turned out to be most abundant channel species could activated by negative pressure at outer side membrane a saturable manner. Assessing single conductance (GΛ) for different monovalent cations revealed increase...
MicroRNAs (miRNAs) regulate the biological properties of colorectal cancer (CRC) cells and might serve as potential prognostic factors therapeutic targets. In this study, we therefore globally profiled miRNAs associated with E-cadherin expression in CRC an attempt to identify that are aggressive clinical course patients. Two cell lines (Caco-2 HRT-18) different pattern were for differences abundance more than 1000 human using microarray technology. One most differentially expressed miRNAs,...
Non-coding RNAs and especially microRNAs have been discovered to act as master regulators of cancer initiation progression. The aim our study was discover characterize the function yet functionally uncharacterized in human breast carcinogenesis. In an unbiased approach, we utilized established model system for (BC) stem cell formation ("mammosphere assay") identify whole miRNome alterations Clinical samples BC patients were used evaluate relevance newly identified miRNA candidates. One...
Metabolic reprogramming is a hallmark of cancer. Understanding cancer metabolism instrumental to devise innovative therapeutic approaches. Anabolic metabolism, including the induction lipogenic enzymes, key feature proliferating cells. Here, we report novel tumor suppressive function for adipose triglyceride lipase (ATGL), rate limiting enzyme in hydrolysis cascade.In immunohistochemical analysis, non-small cell lung cancers, pancreatic adenocarcinoma as well leiomyosarcoma showed...
Abstract The RNA-binding protein ALYREF (THOC4) is involved in transcriptional regulation and nuclear mRNA export, though its role molecular mode of action breast carcinogenesis are completely unknown. Here, we identified high expression as a factor for poor survival cancer patients. significantly influenced cellular growth, apoptosis mitochondrial energy metabolism cells well tumorigenesis orthotopic mouse models. Transcriptional profiling, phenocopy rescue experiments the short isoform...
Huntington's disease (HD) is a progressive neurodegenerative disorder caused by CAG-repeat expansion in exon-1 of the huntingtin gene. Currently, no disease-modifying therapies are available, with significant challenge evaluating therapeutic efficacy before clinical symptoms emerge. This highlights need for early biomarkers and intervention strategies. Therefore, it essential to develop characterize accurate mouse models identify preclinical development. In this study, we characterized...
Dronedarone was introduced in 2009 as a new antiarrhythmic agent and since then has been increasingly prescribed atrial fibrillation or flutter. To date, two cases of severe toxic hepatitis have reported patients treated with dronedarone, both requiring emergency liver transplantation, the FDA well EMA issued warnings about possible hepatotoxicity dronedarone. Here we report an additional case associated dronedarone presenting acute failure, followed by spontaneous recovery, 69-year old...
Usual ductal hyperplasia (UDH) of the breast is generally regarded as a nonneoplastic proliferation, albeit loss heterozygosity has long been reported in part these lesions. To gain deeper insights into molecular drivers lesions, an extended mutation profiling was performed. The coding regions 409 cancer-related genes were investigated by next-generation sequencing 16 cases UDH, nine unassociated with neoplasia (classic) and seven arising within papillomas. Phosphatidylinositol...
// Sarah Kammerer 1, 2 , Armin Sokolowski 9 Hubert Hackl 3 Dieter Platzer 1 Stephan Wenzel Jahn 4 Amin El-Heliebi 5 Daniela Schwarzenbacher 6 Verena Stiegelbauer Martin Pichler 6, 7 Simin Rezania Heidelinde Fiegl 8 Florentia Peintinger Peter Regitnig Gerald Hoefler Wolfgang Schreibmayer Thomas Bauernhofer 2, Molecular Physiology Group, Institute of Biophysics, Medical University Graz, Austria Research Unit on Ion Channels and Cancer Biology, Division Bioinformatics, Biocenter, Innsbruck,...
Tumor heterogeneity is considered a major cause for therapy resistance in colorectal cancer. Sub-populations of cells with different genetic alterations may exist spatially distinct areas. Upon therapy, resistant sub-clones enrich and ultimately lead to disease progression. Although ample data are available on tumors which heterogeneous morphological level, only little known about morphologically homogeneous tumors. We aimed investigate if cancer can harbor landscape. chose microdissect six...
Germline genetic testing for familial cancer syndromes is usually performed serially the most likely causes. In recent years way carried out has changed, as next generation sequencing now allows simultaneous of multiple susceptibility genes at low costs. Here, we present a female with bilateral breast and endometrial adenocarcinoma. After 150 (890 kb) associated hereditary identified pathogenic mutations in two high-penetrance genes, i.e. TP53 CDH1 that would not have been elucidated by...
Overexpression the KCNJ3, a gene that encodes subunit 1 of G-protein activated inwardly rectifying K+ channel (GIRK1) in primary tumor has been found to be associated with reduced survival times and increased lymph node metastasis breast cancer patients. In order survey possible tumorigenic properties GIRK1 overexpression, range malignant mammary epithelial cells, based on MCF-7 cell line permanently overexpress different splice variants KCNJ3 (GIRK1a, GIRK1c, GIRK1d as control, eYFP) were...
Inter-test concordance between the MammaPrint and EndoPredict tests used to predict risk of recurrence in breast cancer was evaluated 94 oestrogen receptor-positive, HER2-negative cancers. We correlated histopathological data with clinical estimation as defined MINDACT trial. 42.6% (40/94) cases were high-risk by MammaPrint, 44.7% (42/94) (EPclin), 45.7% (43/94) definition. Thirty-six percent genomic predictions discordant a low inter-test correlation (p = 0.012; κ 0.27, 95% CI [0.069,...
The analysis of cell-free DNA (cfDNA) in plasma represents a rapidly advancing field medicine. cfDNA consists predominantly nucleosome-protected shed into the bloodstream by cells undergoing apoptosis. We performed whole-genome sequencing (WGS) and identified two discrete regions at transcription start sites (TSS) where nucleosome occupancy results different read-depth coverage patterns expressed silent genes. By employing machine learning for gene classification, we found that read depth...
Background: Molecular profiling (MP) represents an opportunity to match patients a targeted therapy and when tumor tissue is unavailable, circulating deoxyribonucleic acid (ctDNA) can be harnessed as non-invasive analyte for this purpose. We evaluated the success of selected by ctDNA in with advanced refractory carcinoma. Patients methods: A blood draw well optional biopsy were obtained MP. Whole-genome sequencing cancer hotspot panel performed, publicly available databases used molecular...