A5044699578- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- Patient Safety and Medication Errors
- Medical Malpractice and Liability Issues
- Acute Myeloid Leukemia Research
- Venous Thromboembolism Diagnosis and Management
- Cancer Genomics and Diagnostics
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Adipokines, Inflammation, and Metabolic Diseases
- Antiplatelet Therapy and Cardiovascular Diseases
- Atrial Fibrillation Management and Outcomes
- Paraoxonase enzyme and polymorphisms
- Cardiovascular Disease and Adiposity
- Intraocular Surgery and Lenses
- Health Systems, Economic Evaluations, Quality of Life
- Liver Disease and Transplantation
- Family and Patient Care in Intensive Care Units
- Lipoproteins and Cardiovascular Health
- Corneal surgery and disorders
- Adolescent Sexual and Reproductive Health
- Healthcare Systems and Technology
- Antibiotic Resistance in Bacteria
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiovascular Health and Disease Prevention
- Vasculitis and related conditions
Medical University of Graz
2015-2024
Kepler Universitätsklinikum
2022
Ludwig Boltzmann Institute for Lung Vascular Research
2020
Medical University of Vienna
2020
Institute for Medical Informatics and Biostatistics
2014-2018
Statistics Austria
2015
Graz University of Technology
2013
The role of subclonal TP53 mutations, defined by a variant allele frequency <20%, has not been addressed in acute myeloid leukemia yet. We, therefore, analyzed their prognostic value cohort 1,537 patients with newly diagnosed disease, prospectively treated within three trials the "German-Austrian Acute Myeloid Leukemia Study Group". Mutational analysis was performed targeted deep sequencing and mutations were categorized into groups frequencies >40%, 20%-40% <20%. A total 108 found 98...
A surgical safety checklist (SSC) was implemented and routinely evaluated within our hospital. The purpose of this study to analyze compliance, knowledge satisfaction with the SSC determine further improvements.The implementation observed in a pilot unit. After roll-out into each operating theater, compliance measured. To assess subjective objective knowledge, as well implementation, an online survey (N = 891) performed.During two test runs piloting unit, 305 operations were observed, 175...
Mutations of the TP53 gene occur in a subset patients with acute myeloid leukemia (AML) and confer an exceedingly adverse prognosis. However, whether different types mutations exert uniformly poor outcome has not been investigated yet. Here, we addressed this issue by analyzing data 1537 intensively treated within protocols German-Austrian AML study group. We classified depending on their impact protein structure according to evolutionary action (EAp53) score relative fitness (RFS). In...
The SALVE Histopathology Group (SHG) developed and validated a grading staging system for the clinical full histological spectrum of alcohol-related liver disease (ALD) evaluated its prognostic utility in multinational cohort 445 patients.SALVE grade was described by semiquantitative scores steatosis, activity (hepatocellular injury lobular neutrophils) cholestasis. diagnosis steatohepatitis due to ALD (histological ASH, hASH) based on presence hepatocellular ballooning neutrophils. Fibrosis...
Abstract Aim Health care–associated infections along with antibiotic resistance are a leading risk for patient safety in intensive care units. Hygienic hand disinfection is still regarded as the most effective, simplest, and cost‐effective measure to reduce health infections. To improve hygiene compliance prevent infections, interventions of “German Clean Hands Campaign” were implemented university hospital. Methods Observational single‐center study using direct observation feedback. Hand...
Obesity is associated with hypoadiponectemia, dyslipidemia, and increased risk of cardiovascular disease (CVD). Mechanisms linking these conditions remain to be fully understood. Cholesterol efflux capacity (CEC) a crucial functional property high-density lipoprotein (HDL) that strongly predicts CVD incidence. We investigated whether age, fat distribution, other obesity-related factors affect CEC in juvenile adult overweight/obese participants the STYJOBS/EDECTA cohort (NCT00482924)....
Abstract Clinical studies have shown that assessing circulating concentrations of high-density lipoprotein (HDL) particles by nuclear magnetic resonance (NMR) spectroscopy is superior to HDL-cholesterol in predicting cardiovascular risk. We tested the hypothesis HDL predict 3-month mortality patients with acute heart failure (AHF). Out 152 included patients, 52% were female, additionally mean patient age was 75.2 ± 10.3 years, and three-month 27%. Serum profile at admission determined NMR...
Abstract Considering the already established relationship between extent of metabolic dysfunction and severity heart failure (HF), it is conceivable that metabolomic profile serum may have a prognostic capacity for 3-month mortality in acute (AHF). Out 152 recruited patients, 130 samples were subjected to analyses. The rate was 24.6% (32 patients). Metabolomic profiling by nuclear magnetic resonance spectroscopy found levels 2-hydroxybutyrate (2-HB), 3-hydoxybutyrate (3-HB), lactate,...
Anti-TNF antibodies were the first biologic treatment option for patients with inflammatory bowel diseases.To assess length of persistence anti-TNF therapy and influencing factors used in standard care diseases.Single-centre, retrospective study from a register including who received last 20 years at centre. Kaplan-Meier analysis log-rank test was to describe persistence. With multivariable Cox regression analysis, risk failure investigated.Five hundred thirty-eight (CD, Crohn's disease:...
Abstract Background Matrix metalloproteinase 12 (MMP12) is a macrophage-secreted protein that massively upregulated as pro-inflammatory factor in metabolic and vascular tissues of mice humans suffering from cardiometabolic diseases (CMDs). However, the molecular mechanisms explaining contributions MMP12 to CMDs are still unclear. Methods We investigated impact deficiency on mouse model mimics human disease by simultaneously developing adipose tissue inflammation, insulin resistance,...
This paper demonstrates the method of design-of-experiment for an aging test two popular lithium ion cell chemistries used in consumer and automotive industry. A design experiment helps to produce statistically repeatable data behavior cells, unlike small scale experiments with single cells and/or influences. After setting up experiment, measurements over 150 cathode iron-phosphate nickel-cobalt-aluminum against a graphite anode are presented. These results then subjected statistical...
Background "The Surgical Safety Checklist (SSC) is important, but we don't use it adequately" a well-suited statement that reflects the SSC's application in hospitals. Our aim was to follow up on our initial study compliance (2014) by analysing differences between individual perception and with SSC. Methods We conducted follow-up online survey assess healthcare professionals' of, as well satisfaction SSC three years following its thorough implementation. Results 171 (19.5%) of 875 operating...
Objective The functionality of high-density lipoprotein (HDL) is impaired in chronic ischaemic heart failure (HF). However, the relationship between HDL and outcomes acute HF (AHF) has not been studied. present study investigates whether metrics functionality, including cholesterol efflux capacity HDL-associated paraoxonase (PON)-1 arylesterase (AE) activity are associated with hospital mortality AHF patients. Methods Results was performed as a prospective, single-centre, observational...
Despite strong evidence that high-density lipoproteins (HDLs) modulate the immune response, role of HDL in allergies is still poorly understood. Many patients with allergic rhinitis (AR) develop a late-phase characterized by infiltration monocytes and eosinophils into nasal submucosa. Functional impairment AR-patients may insufficiently suppress inflammation cell infiltration, but effect AR on composition function not We used apolipoprotein (apo) B-depleted serum as well isolated from (n =...
Platelet-rich plasma injections have been presented as an effective treatment for androgenetic alopecia; however, reliable study data concerning this therapy are lacking. The current randomized, placebo-controlled pilot explored novel in 30 healthy male subjects with alopecia. Five platelet-rich treatments, at intervals of 4?6 weeks, and 2 follow-up examinations were performed. Twenty injected intracutaneously 10 physiological saline. Treatment efficacy was assessed by changes hair number...
While hospital admissions for myocardial infarction (MI) and pulmonary embolism (PE) are decreased during the COVID-19 pandemic, controversy remains about respective complication mortality rates. This study evaluated admission rates, complications, intrahospital selected life-threatening cardiovascular emergencies (MI, PE, acute aortic dissection (AAD)) COVID-19-associated restrictive social measures (RM) in Styria, Austria. By screening a patient information system International Statistical...
To assess intima-media thickness (IMT) changes measured by ultrasound in axillary arteries of giant cell arteritis (GCA) patients over time and to calculate an cut-off value for the diagnosis chronic artery involvement with longstanding GCA.Ultrasound both was performed 109 GCA at several follow-up visits 40 healthy controls (HCs). IMT determined prospective visit compared between (axGCA) without (non-axGCA) vasculitis baseline, as well HCs. Changes were depicted. Receiver operating...
Abstract Background Chronic myelomonocytic leukemia (CMML) is an aggressive hematopoietic malignancy that arises from stem and progenitor cells (HSPCs). Patients with CMML are frequently treated epigenetic therapeutic approaches, in particular the hypomethylating agents (HMAs), azacitidine (Aza) decitabine (Dec). Although HMAs believed to mediate their efficacy via re-expression of hypermethylated tumor suppressors, knowledge about relevant HMA targets scarce. As silencing tumor-suppressive...
Metabolic syndrome (MS) is characterized by endothelial- and high-density lipoprotein (HDL) dysfunction increased endothelial lipase (EL) serum levels. We examined the associations between EL levels, HDL (serum lipid content, function), function in healthy volunteers (HV) MS patients. Flow-mediated dilation (FMD), nitroglycerin-mediated (NMD), levels of subclasses (measured nuclear magnetic resonance (NMR) spectroscopy), differed significantly HV The triglycerides large particles were...
The discharge summary (DS) is one of the most important instruments to transmit information treating general physician (GP). objective this study was analyse components DS, structural characteristics as well medical and abbreviations.One hundred randomly selected DS from five different clinics were evaluated by independent reviewers regarding content, structure, abbreviations conformity Austrian Electronic Health Records (ELGA) using a structured case report form. Abbreviations all 100...