A5038074945- Inflammatory Bowel Disease
- Microscopic Colitis
- Liver Disease Diagnosis and Treatment
- Gut microbiota and health
- Liver Disease and Transplantation
- Biosimilars and Bioanalytical Methods
- Gastroesophageal reflux and treatments
- Alcohol Consumption and Health Effects
- Clostridium difficile and Clostridium perfringens research
- Gastrointestinal disorders and treatments
- Immunodeficiency and Autoimmune Disorders
- Fatty Acid Research and Health
- Potassium and Related Disorders
- Renal function and acid-base balance
- Eosinophilic Esophagitis
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer therapeutics and mechanisms
- Pharmaceutical Economics and Policy
- Metastasis and carcinoma case studies
- Pharmacological Effects of Natural Compounds
- Liver Diseases and Immunity
- Celiac Disease Research and Management
- Genital Health and Disease
- Chronic Lymphocytic Leukemia Research
- Esophageal and GI Pathology
Medical University of Graz
2014-2025
Medical University of Vienna
2023
Taipei Institute of Pathology
2015
Forschungs- und Beratungsstelle Arbeitswelt
2008
High-density lipoprotein cholesterol (HDL-C) levels are reduced in patients with chronic liver disease and inversely correlate severity. During acute conditions such as sepsis, HDL-C decrease rapidly HDL particles undergo profound changes their composition function. We aimed to determine whether indices of quantity quality associate progression survival advanced disease.
The SALVE Histopathology Group (SHG) developed and validated a grading staging system for the clinical full histological spectrum of alcohol-related liver disease (ALD) evaluated its prognostic utility in multinational cohort 445 patients.SALVE grade was described by semiquantitative scores steatosis, activity (hepatocellular injury lobular neutrophils) cholestasis. diagnosis steatohepatitis due to ALD (histological ASH, hASH) based on presence hepatocellular ballooning neutrophils. Fibrosis...
Anti-TNF antibodies were the first biologic treatment option for patients with inflammatory bowel diseases.To assess length of persistence anti-TNF therapy and influencing factors used in standard care diseases.Single-centre, retrospective study from a register including who received last 20 years at centre. Kaplan-Meier analysis log-rank test was to describe persistence. With multivariable Cox regression analysis, risk failure investigated.Five hundred thirty-eight (CD, Crohn's disease:...
Abstract The gut microbiome contributes to chronic inflammatory responses in ulcerative colitis (UC), but molecular mechanisms and disease-relevant effectors remain unclear. Here we analyze the pro-inflammatory properties of colonic fluid obtained during colonoscopy from UC control patients. In patients with UC, find that pelletable effector fraction is composed mostly bacterial extracellular vesicles (BEVs) exhibit high IgA-levels incite strong IgA receptor-positive (CD89 + ) immune cells....
Abstract Background The fecal microbiome of patients with inflammatory bowel diseases (IBD) is characterized by longitudinal variability. It remains unknown if this caused decreased resilience the to external factors. We investigated influence osmotic diarrhea induced preparation as a disruptive factor on in IBD and healthy comparators. Methods conducted prospective, single-center study including controls scheduled for colonoscopy uniform preparation. Fecal samples were collected at 7 time...
Abstract Background Corticosteroids are used for induction of remission in patients with moderately to severely active ulcerative colitis. However, up one-third fail this therapy. We investigated if fecal microbial composition or its metabolic capacity associated response systemic corticosteroids. Methods In prospective, multicenter study, colitis (Lichtiger score ≥4) receiving corticosteroids were eligible. Data assessed and samples collected before after 4 weeks treatment. Patients divided...
The incidence of sexually transmitted infections (STIs) is unbridled and on the rise. Extragenital STIs (anal pharyngeal infections) are commonly asymptomatic, resulting in delayed diagnosis treatment consequently higher chances onward transmission.
In April 2020 during the coronavirus disease 2019 (COVID-19) pandemic, a 41-year-old female presented to emergency department with recurrent vomiting and abdominal pain that had been ongoing for 2 days haematemesis present several hours. The past medical history was unremarkable, except bariatric gastric bypass surgery performed in 2016. During detailed inquiry, patient reported she intentionally taken 10 ml of ethanol-containing hand disinfectant orally each day period of> 3 weeks fear...
Among patients with ulcerative colitis, 30-50% receive corticosteroids within the first five years after diagnosis. We aimed to reconsider their effectiveness in context of biologic era.In this prospective, multicenter study, active colitis (Lichtiger score ≥ 4) were eligible if initiating systemic corticosteroids. The primary endpoint was clinical response (decrease Lichtiger ≥50%) at week 4. Secondary endpoints included combined defined as and any reduction elevated biomarkers (CRP and/or...
An elderly female patient was admitted to intensive care for prolonged vasopressor therapy and mechanical ventilation after cardiac arrest acute percutaneous coronary intervention. Antiplatelet, thyroid hormone replacement statin therapies were administered through a 14-French nasogastric tube (Nestlé Health Science) enteral feeding initiated. Correct position of the confirmed radiologically. On seventh day in care, our seen regurgitate soft crumbs into her mouth. The blocked removed, but...
Background and aims Immunological treatment failure of anti-TNF therapy negatively influences persistence a second in IBD patients. So far it is unknown if this effect also observed for other monoclonal antibodies. We assessed the influence immunogenicity to anti-TNFs on subsequent ustekinumab vedolizumab therapy.Methods patients with without (undetectable trough levels antibody titers ≥20 ng/mL) (UST) and/or (VDZ) were included retrospective, single-center study. The Kaplan-Meier method...
Histological subclassification of cirrhosis may allow for the definition severe fibrosis stages with different clinical severity and prognosis. However, value histological staging is limited by intra- interobserver variability. We therefore aimed to determine relationship between morphometrically quantified measured as collagen proportionate area …
Background The gut microbiome of patients with inflammatory bowel diseases (IBD) is characterized by increased longitudinal variability. It remains unknown if this caused instability the to external factors. We investigated influence osmotic diarrhea induced preparation as an source irritation on in IBD and healthy comparators.
Due to constantly rising therapy costs, biosimilars and generic drugs have gained tremendous importance through recent decades. Nevertheless, the acceptance among healthcare workers regarding in previously published international studies is considerably lower than scientific data on equivalent safety efficacy would suggest. The aim of this questionnaire-based survey was determine perception knowledge by medical professionals from different facilities Vienna, Austria.
Presentation of case
Hintergrund und Ziele Systemischen Kortikosteroide sind eine wichtige Substanzgruppe in der Behandlung aktiven Colitis ulcerosa (CU). Das Ansprechen auf medikamentöse Therapien wie Biologika wird mutmaßlich durch das Darmmikrobiom beeinflusst. Wir untersuchten ob die Zusammensetzung Funktion des Mikrobioms bei Patienten mit aktiver CU auch Zusammenhang dem Therapieansprechen steht.
Abstract Background Anti-TNF therapy is still the most frequently used first-line biologic treatment in inflammatory bowel disease (IBD). This study aimed to determine length of persistence and describe reasons for discontinuation anti-TNF standard care IBD patients. Methods A single-center, real-world, retrospective including patients (Crohn’s (CD), ulcerative colitis (UC), unclassified (IBD-U)), who received an last 20 years at center, was conducted. Length therapy, differences duration...