A5010042062- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Educator Training and Historical Pedagogy
- Cancer, Lipids, and Metabolism
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- Cancer-related Molecular Pathways
- Cancer Cells and Metastasis
- Sociology and Education Studies
- Education Methods and Technologies
- Circular RNAs in diseases
- Biosimilars and Bioanalytical Methods
- Plant Disease Resistance and Genetics
- Radiopharmaceutical Chemistry and Applications
- Educational Strategies and Epistemologies
- Biotin and Related Studies
- Cancer Mechanisms and Therapy
- PI3K/AKT/mTOR signaling in cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
Medical University of Graz
2020-2024
Abstract The RNA-binding protein ALYREF (THOC4) is involved in transcriptional regulation and nuclear mRNA export, though its role molecular mode of action breast carcinogenesis are completely unknown. Here, we identified high expression as a factor for poor survival cancer patients. significantly influenced cellular growth, apoptosis mitochondrial energy metabolism cells well tumorigenesis orthotopic mouse models. Transcriptional profiling, phenocopy rescue experiments the short isoform...
Metabolic reprogramming is considered as a hallmark of cancer and clinically exploited novel target for therapy. The E2F transcription factor-1 (E2F1) regulates various cellular processes, including proliferative metabolic pathways, acts, depending on the molecular context, an oncogene or tumor suppressor. latter evident by observation that E2f1-knockout mice develop spontaneous tumors, uterine sarcomas. This dual role warrants detailed investigation how E2F1 loss impacts pathways related to...
Abstract Background Triple negative breast cancer (TNBC) is a particularly aggressive and difficult-to-treat subtype of that requires the development novel therapeutic strategies. To pave way for such developments it essential to characterize new molecular players in TNBC. MicroRNAs (miRNAs) constitute interesting candidates this regard as they are frequently deregulated contribute numerous aspects carcinogenesis. Methods results Here, we discovered miR-4649-5p, miRNA yet uncharacterized...
Biliary tract cancer is a major global health issue in cancer-related mortality. Therapeutic options are limited, and cisplatin-based treatment schedules represent the mainstay of first-line therapeutic strategies. Although gain survival by addition cisplatin to gemcitabine moderate, acquired resistance frequently leads failures with mechanisms that still poorly understood. Epithelial–mesenchymal transition (EMT) dynamic process changes shape, function, gene expression pattern biliary cells....
The microRNA-200 family has wide-ranging regulatory functions in cancer development and progression. Above all, it is strongly associated with the epithelial-to-mesenchymal transition (EMT), a process during which cells change their epithelial to mesenchymal phenotype acquire invasive characteristics. More recently, miR-200 members have also been reported impact immune evasion of by regulating expression immunoinhibitory checkpoints (ICs) like PD-L1. Therefore, we aimed comprehensively...
MicroRNAs are well established as master regulators of carcinogenesis and potential biomarkers in breast cancer (BC). In a preliminary effort, we found miR-27a-5p to be significantly downregulated experimentally derived mammospheres BC patients from The Cancer Genome Atlas Breast Invasive Carcinoma (TCGA-BRCA) dataset.
MicroRNAs (miRNAs) are crucial post-transcriptional regulators of gene expression, and their deregulation contributes to many aspects cancer development progression. Thus, miRNAs provide insight into oncogenic mechanisms represent promising targets for new therapeutic approaches. A type that is still in urgent need improved treatment options triple negative breast (TNBC). Therefore, we aimed characterize a novel miRNA with potential role TNBC. Based on previous study, selected miR-4646-5p,...