A5071086154- Hypothalamic control of reproductive hormones
- Epigenetics and DNA Methylation
- Growth Hormone and Insulin-like Growth Factors
- Metabolism and Genetic Disorders
- Diet and metabolism studies
- Neurogenesis and neuroplasticity mechanisms
- Neuroendocrine regulation and behavior
- Cancer, Hypoxia, and Metabolism
- Amino Acid Enzymes and Metabolism
- Metabolomics and Mass Spectrometry Studies
- Diet, Metabolism, and Disease
- Adipose Tissue and Metabolism
- Hormonal and reproductive studies
- Reproductive System and Pregnancy
- Regulation of Appetite and Obesity
- Ovarian function and disorders
- Fibroblast Growth Factor Research
- Reproductive Biology and Fertility
- Ovarian cancer diagnosis and treatment
- Analytical Chemistry and Chromatography
- Steroid Chemistry and Biochemistry
- Testicular diseases and treatments
- Pituitary Gland Disorders and Treatments
- Infant Health and Development
- Healthcare Systems and Practices
University of Lausanne
2015-2024
SIB Swiss Institute of Bioinformatics
2023
Sanofi (United States)
2018-2022
Northeastern University
2021
Framingham State University
2018
Physiologie de la Reproduction et des Comportements
2010-2017
Université de Tours
2013-2017
Centre National de la Recherche Scientifique
2013-2017
Institut Français
2015
Institut Français du Cheval et de l'Équitation
2015
Abstract During development, GnRH‐1 neurons differentiate extracerebraly from the nasal placode and migrate vomeronasal organ to forebrain along terminal nerves. Numerous studies have described influence of different molecules on migration neurons, however, role microenvironment cells remains poorly understood. This study used GFAP‐GFP transgenic mice detect glial at early developmental stages. Using explant cultures, comigration with was clearly demonstrated. in vitro approach showed that...
The neuropathological effects of phenylketonuria (PKU) stem from the inability body to metabolize excess phenylalanine (Phe), resulting in accumulation Phe blood and brain. Since kidney normally reabsorbs circulating amino acids with high efficiency, we hypothesized that preventing renal uptake might provide a disposal pathway could lower systemic levels. SLC6A19 is neutral acid transporter responsible for absorption majority free small intestine reuptake by proximal tubule cells. Transgenic...
Monocarboxylates have been implicated in the control of energy homeostasis. Among them, putative role ketone bodies produced notably during high-fat diet (HFD) has not thoroughly explored. In this study, we aimed to determine impact a specific rise cerebral on food intake and homeostasis regulation. A carotid infusion was performed mice stimulate sensitive brain areas for 6 or 12 h. At each time point, different markers were analyzed reveal consequences increase body level detection. First,...
Metabolic reprogramming is considered as a hallmark of cancer and clinically exploited novel target for therapy. The E2F transcription factor-1 (E2F1) regulates various cellular processes, including proliferative metabolic pathways, acts, depending on the molecular context, an oncogene or tumor suppressor. latter evident by observation that E2f1-knockout mice develop spontaneous tumors, uterine sarcomas. This dual role warrants detailed investigation how E2F1 loss impacts pathways related to...
Ketone bodies have been shown to transiently stimulate food intake and modify energy homeostasis regulatory systems following cerebral infusion for a moderate period of time (<6 hours). As ketone are usually enhanced during episodes fasting, this effect might correspond physiological regulation. In contrast, levels remain elevated prolonged periods obesity, thus could play an important role in the development pathology. order understand transition, were infused through catheter inserted...
Episodic release of GnRH is essential for reproductive function. In vitro studies have established that this episodic an endogenous property neurons and secretory pulses are associated with synchronization neuron activity. The cellular mechanisms by which synchronize remain largely unknown. There no clear evidence physical coupling through gap junctions to explain synchronization. However, glial cells has been shown regulate activity in their microenvironment. present study investigated...
Abstract Phenylketonuria (PKU) is a genetic deficiency of phenylalanine hydroxylase (PAH) in liver resulting blood (Phe) elevation and neurotoxicity. A pegylated ammonia lyase (PEG-PAL) metabolizing Phe into cinnamic acid was recently approved as treatment for PKU patients. potentially one-time rAAV-based delivery PAH gene to convert tyrosine (Tyr), normal way metabolism, has now also entered the clinic. To understand differences between these two lowering strategies, we evaluated PAL...
The recombinant Lonomia obliqua Stuart-factor activator (rLosac) is a hemolin which belongs to the immunoglobulin superfamily of cell adhesion molecules. It capable inducing pro-survival activity in serum-deprived human umbilical vein endothelial cells (HUVECs) and fibroblasts by increasing mitochondrial metabolism. We hypothesize that it could promote neuronal survival acting on neuroenergetics. Our study reveals treatment primary mouse cortical neurons cultured neurobasal medium lacking...
Article12 July 2020Open Access Source DataTransparent process Hypothalamic CDK4 regulates thermogenesis by modulating sympathetic innervation of adipose tissues Judit Castillo-Armengol orcid.org/0000-0001-7833-0569 Center for Integrative Genomics, University Lausanne, Switzerland Search more papers this author Valentin Barquissau Sarah Geller Honglei Ji Ilenia Severi Department Experimental and Clinical Medicine, Marche Polytechnic University, Ancona, Italy Wiebe Venema Eric Aria Fenandez...
During mammalian embryonic development, GnRH neurones differentiate from the nasal placode and migrate through septum towards forebrain. We previously showed that a category of glial cells, olfactory ensheathing cells (OEC), forms microenvironment migrating neurones. Here, to characterize quantitative qualitative importance this glial, we investigated spatiotemporal maturation in situ role maturing glia development ex vivo. More than 90% were found be associated with cells. There was no...
Phenylketonuria (PKU) is an autosomal recessive inborn error of L-phenylalanine (Phe) metabolism. It caused by a partial or complete deficiency the enzyme phenylalanine hydroxylase (PAH), which necessary for conversion Phe to tyrosine (Tyr). This metabolic results in buildup and reduction Tyr concentration blood brain, leading neurological disease intellectual deficits. Patients exhibit retarded body growth, hypopigmentation, hypocholesterolemia low levels neurotransmitters. Here we report...
Microscale-based separations are increasingly being applied in the field of metabolomics for analysis small-molecule metabolites. These methods have potential to provide improved sensitivity, less solvent waste, and reduced sample-size requirements. Ion-pair free microflow-based global methods, which we recently reported, were further compared analytical flow ion-pairing reagent containing using a sample set from urea cycle disorder (UCD) mouse model. Mouse urine brain homogenate samples...
Abstract Cyclin-dependent kinase 4 (CDK4) canonical role is to control cell cycle progression from G1 S phases. However, recent studies reported that CDK4 regulates energy metabolism in non-proliferating cells such as hepatocytes or adipocytes. The objective of our work study function skeletal muscle using a model mice lacking ( cdk4 -/- ). By coupling treadmill running indirect calorimetry, we show display improved endurance and higher capacity use fat fuel during exercise. Isolated muscles...
The researcher proceeds from the experimental findings of Amonteas, which, by injecting strychnine into certain motor and sensory centers cortex, received corresponding epileptogenic zones on skin.