A5012484710- Cancer-related molecular mechanisms research
- Inflammatory Biomarkers in Disease Prognosis
- Cancer Immunotherapy and Biomarkers
- MicroRNA in disease regulation
- Pancreatic and Hepatic Oncology Research
- Circular RNAs in diseases
- Renal cell carcinoma treatment
- Venous Thromboembolism Diagnosis and Management
- Bladder and Urothelial Cancer Treatments
- Cancer Genomics and Diagnostics
- Cancer, Lipids, and Metabolism
- Urinary and Genital Oncology Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Algebraic Geometry and Number Theory
- RNA modifications and cancer
- Cancer Treatment and Pharmacology
- PARP inhibition in cancer therapy
- Antiplatelet Therapy and Cardiovascular Diseases
- Advanced Algebra and Geometry
- Cancer, Hypoxia, and Metabolism
- Renal and related cancers
- Sarcoma Diagnosis and Treatment
- Esophageal Cancer Research and Treatment
- Finite Group Theory Research
- Prostate Cancer Treatment and Research
Medical University of Graz
2019-2025
University of Graz
2024
Comprehensive Cancer Center Vienna
2022
The University of Texas MD Anderson Cancer Center
2020-2021
Background: Biomarkers for predicting response to immune checkpoint inhibitors (ICI) are scarce and often lack external validation. This study provides a comprehensive investigation of pretreatment C-reactive protein (CRP) levels as well its longitudinal trajectories marker treatment disease outcome in patients with advanced non-small cell lung cancer (NSCLC) undergoing immunotherapy anti PD-1 or PD-L1 agents. Methods: We performed retrospective bi-center assess the association between...
Gemcitabine/nab-paclitaxel (GN) and FOLFIRINOX are standard first-line treatment options for advanced pancreatic ductal adenocarcinoma (aPDAC), but currently no prospective randomised head-to-head comparison between these treatments has yet been performed.We conducted a comparative propensity score (PS) analysis of overall (OS) progression-free survival (PFS) in tri-centre cohort patients with aPDAC undergoing palliative either GN or FOLFIRINOX.In unadjusted analysis, OS PFS were highly...
Renal cell carcinoma (RCC) is frequently infiltrated by immune cells, a process which governed chemokines. CD8 + T cells in the RCC tumor microenvironment (TME) may be exhausted most likely influence therapy response and survival. The aim of this study was to evaluate chemokine-driven recruitment, exhaustion TME, as well metabolic processes leading their functional anergy RCC. Eight publicly available bulk transcriptome collectives (n=1819) single RNAseq dataset (n=12) were analyzed....
Immune checkpoint inhibitors (ICIs) have revolutionized systemic anti-tumor treatments across different types of cancer. Nevertheless, predictive biomarkers regarding treatment response are not routinely established yet. Apart from T-lymphocytes, the humoral immunity B-lymphocytes is studied to a substantially lesser extent in respective setting. Thus, aim this study was evaluate peripheral blood B-cell subtypes as potential predictors ICI response.
Abstract Background The presence of autoantibodies in the serum cancer patients has been associated with immune‐checkpoint inhibitor (ICI) therapy response and immune‐related adverse events (irAEs). A prospective evaluation different entities is missing. Materials Methods In this cohort study, we included a pan‐cancer undergoing ICI treatment measured comprehensive panel at start time point first evaluation. induction (ANA, ENA, myositis, hepatopathy, rheumatoid arthritis) were assessed...
Background C reactive protein (CRP) kinetics have recently been suggested as predictive biomarkers for the efficacy of immune checkpoint inhibitor (ICI) therapy in selected cancer types. The aim this study was to characterize early CRP a tumor-agnostic biomarker ICI treatment outcomes. Methods In multicenter retrospective cohort study, two independent cohorts patients with various types undergoing palliative at Austrian academic centers served discovery (n=562) and validation (n=474). Four...
Background/Aim: The Aspartate aminotransaminase/Alanine aminotransaminase ratio (AST/ALT ratio) has been identified as a prognostic marker for several malignancies. In this study, we evaluated the value of AST/ALT in large cohort non-metastatic colorectal cancer patients (CRC). Patients and Methods: A total 536 with stage II III CRC, well available were included single-center retrospective analysis. Laboratory data measured within two weeks before histological tumor diagnosis. Co-Primary...
Upper tract urothelial carcinoma (UTUC) is an aggressive disease that managed by radical or organ-sparing surgery. High recurrence rates require early detection and strict follow-up (FU) protocols. Recommendations are assigned to a low level of evidence. Our aim was identify time-to-tumor recurrence, analyze the temporal relation recommended FU regimens, provide critical proposal for further surveillance. This retrospective study included 54 patients receiving nephroureterectomy (RNU) in...
Introduction: The activity of butyrylcholinesterase (BChE) in blood reflects liver function and has recently been associated with systemic inflammatory response tumor cachexia. As these conditions have previously linked pancreatic cancer (PC), the purpose present study was to evaluate prognostic impact plasma BChE PC. Methods: Data from 574 consecutive PC patients, treated between 2004 2018 at a single academic center, evaluated. primary endpoint cancer-specific survival (CSS), analyzed by...
POU3F3 adjacent non-coding transcript 1 (PANTR1) is an oncogenic long RNA with significant influence on numerous cellular features in different types of cancer. No characterization its role renal cell carcinoma (RCC) yet available. In this study, PANTR1 expression was confined to human brain and kidney tissue found significantly up-regulated clear-cell (ccRCC) compared non-cancerous two independent cohorts (
The advanced lung cancer inflammation index (ALI) was first introduced for prognosis prediction in patients and since then evaluated several other malignancies. However, pancreatic (PC) the ALI its prognostic utility were only investigated a comparably small specific cohort of locally PC treated with chemoradiotherapy.In our single-center study, we included 429 histologically verified who between 2003 2015 at academic institution. defined as body mass (BMI; kg/m2 ) × serum albumin levels...
Testicular germ cell tumors (TGCTs) are the most commonly diagnosed malignancies in younger men. The monitoring of disease course and recurrence is supported by traditional tumor markers, including α-fetoprotein (AFP). AFP physiologically synthesized liver can be detected at increased levels testicular cancer patients as well under other benign diseases, which have been reported a misleading cause interpretation TGCTs clinical course. A cluster stem cell-associated microRNAs has to...
To quantify the magnitude of benefit metastasectomy as compared to medical treatment alone in patients with metastatic renal cell carcinoma (mRCC).We therefore conducted a propensity score analysis overall survival (OS) 106 mRCC metachronous metastasis, whom 36 (34%) were treated metastasectomy, and 70 (66%) therapy alone.The most frequent procedures lung resections (n = 13) craniotomies 6). Median time-to-progression after was 0.7 years (25th-75th percentile: 0.3-2.7). After median...
Clinical trials investigating efficacy of immune checkpoint inhibitors (ICI) revealed sex-specific divergent outcomes in urothelial cancer (UC), suggesting that sex hormones might play an important role gender-specific dimorphisms response upon ICI. However, further clinical investigations are still needed to understand the influence UC. The aim this study was get insights on prognostic and predictive value hormone levels patients with metastatic UC (mUC) who underwent ICI.Sex mUC including...
Abstract Introduction Recent advances in prophylactic anticoagulation and antineoplastic treatment for advanced pancreatic cancer (aPC) warrant an updated reassessment of thromboembolic risk this population. This multicenter retrospective cohort study aims to comprehensively characterize incidence, factors, outcomes venous (VTE) arterial thromboembolism (ATE) homogenously treated patients with aPC. Methods Four hundred fifty-five aPC undergoing palliative first-line chemotherapy...
<h3>Abstract</h3> Background: The detection of prostate cancer (PCa) is currently based on prostate-specific antigen (PSA) quantification as an initial screening followed by ultrasound-guided transrectal biopsy. However, the high rate false-negative biopsies often leads to inappropriate treatment. Therefore, new molecular biomarkers, such urine microRNAs (miRNAs), are a possible way redefine PCa diagnostics. Patients and Methods: Urine samples 356 patients undergoing biopsy (256 cases with...