A5091122349- Immune cells in cancer
- Single-cell and spatial transcriptomics
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Lung Cancer Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Innovations in Medical Education
- Neutropenia and Cancer Infections
- Cancer Research and Treatments
- Venous Thromboembolism Diagnosis and Management
- Simulation-Based Education in Healthcare
- Clinical Reasoning and Diagnostic Skills
- Lymphoma Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Esophageal Cancer Research and Treatment
- Aortic Thrombus and Embolism
- Celiac Disease Research and Management
- Cancer, Lipids, and Metabolism
- Cell Adhesion Molecules Research
- Histone Deacetylase Inhibitors Research
- Otitis Media and Relapsing Polychondritis
- Hematopoietic Stem Cell Transplantation
Innsbruck Medical University
2020-2024
Tyrolean Cancer Research Institute
2022-2024
Universität Innsbruck
2020-2024
Garvan Institute of Medical Research
2009
Royal Prince Alfred Hospital
2005
Non-small cell lung cancer (NSCLC) is characterized by molecular heterogeneity with diverse immune infiltration patterns, which has been linked to therapy sensitivity and resistance. However, full understanding of how phenotypes vary across different patient subgroups lacking. Here, we dissect the NSCLC tumor microenvironment at high resolution integrating 1,283,972 single cells from 556 samples 318 patients 29 datasets, including our dataset capturing low mRNA content. We stratify into...
Neutrophils represent the most abundant myeloid cell subtype in non-small-cell lung cancer (NSCLC) tumor microenvironment (TME). By anti- or protumor polarization, they impact multiple aspects of biology and affect sensitivity to conventional therapies immunotherapies. Single-cell RNA sequencing (scRNA-seq) analyses have unraveled an extensive neutrophil heterogeneity, helping our understanding their pleiotropic role. In this review we summarize recent data models on tumor-associated (TAN)...
Gemcitabine/nab-paclitaxel (GN) and FOLFIRINOX are standard first-line treatment options for advanced pancreatic ductal adenocarcinoma (aPDAC), but currently no prospective randomised head-to-head comparison between these treatments has yet been performed.We conducted a comparative propensity score (PS) analysis of overall (OS) progression-free survival (PFS) in tri-centre cohort patients with aPDAC undergoing palliative either GN or FOLFIRINOX.In unadjusted analysis, OS PFS were highly...
SUMMARY Non-small cell lung cancer (NSCLC) is characterized by molecular heterogeneity with diverse immune infiltration patterns, which has been linked to both, therapy sensitivity and resistance. However, full understanding of how phenotypes vary across different patient tumor subgroups lacking. Here, we dissect the NSCLC microenvironment at high resolution integrating 1,212,463 single-cells from 538 samples 309 patients 29 datasets, including our own dataset capturing cells low mRNA...
Summary The biology of non-small cell lung cancer (NSCLC) is driven by a complex mutational landscape, and the detection driver molecular alterations next-generation sequencing key for identification druggable alterations. Thus, broad profiling displays standard-of-care approach particularly in patients with advanced adenocarcinoma at time initial diagnosis, but also acquired resistance to tyrosine kinase inhibitors, guiding further treatment choices. Sequencing plasma-circulating tumor DNA...
Abstract Introduction Recent advances in prophylactic anticoagulation and antineoplastic treatment for advanced pancreatic cancer (aPC) warrant an updated reassessment of thromboembolic risk this population. This multicenter retrospective cohort study aims to comprehensively characterize incidence, factors, outcomes venous (VTE) arterial thromboembolism (ATE) homogenously treated patients with aPC. Methods Four hundred fifty-five aPC undergoing palliative first-line chemotherapy...
SUMMARY The immune composition of the tumor microenvironment (TME) has a major impact on therapeutic response and clinical outcome in patients with colorectal cancer (CRC). Here, we comprehensively characterize TME at single-cell level by first building large-scale atlas that integrates 4.27 million single cells from 1,670 patient samples. We then complemented profiles four CRC cohorts 266 patients, including low mRNA content, spatial transcriptional 3.7 cells, protein 0.7 cells. analysis...
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Abstract Background Assessments, such as summative structured examinations, aim to verify whether students have acquired the necessary competencies. It is important familiarize with examination format prior assessment ensure that true competency measured. However, it unclear can demonstrate their potential or possibly perform less effectively due unfamiliar format. Hence, we questioned a 10-min active familiarization in form of simulation improved medical students´ OSCE performance. Next,...
Background: The level of evidence for palliative second-line therapy in advanced esophageal squamous cell carcinoma (aESCC) is limited. This the first study that reports efficacy data comparing + active symptom control (ASC) versus ASC alone aESCC. Methods: We conducted a tri-center retrospective cohort ( n = 166) including patients with aESCC who had experienced disease progression on first-line therapy. A propensity score model using inverse probability treatment weighting (IPTW) was...
Combined 18 F-fluoro-deoxyglucose ([18F]FDG) positron emission tomography and computed ([18F]FDG-PET/CT) is increasingly used for the diagnostic therapeutic management of hematologic non-hematologic malignancies. Here, we describe a unique case patient presenting with very severe aplastic anemia mediastinal mass showing disseminated hypermetabolic lesions bones after receiving granulocyte colony-stimulating factor (G-CSF), highly suspicious metastatic lesions. A 71-year-old presented 3 week...
Background Enteropathy-associated T cell lymphoma (EATL) is an aggressive intestinal derived from intraepithelial lymphocytes, which occurs in individuals with celiac disease (CD). Cerebral involvement extremely rare condition and as described so far, lesions may present parenchymal predo-minantly supratentorial or leptomeningeal involvement. We describe a case of EATL multifocal supra- infratentorial brain patient refractory (RCD). Case summary A 58-years old man known CD developed...
Summary This article intends to summarize personal non-small cell lung cancer (NSCLC) highlights of the ESMO 2019 meeting. Again, immunotherapy in first-line setting wildtype NSCLC was a major aspect and search optimal biomarker for therapy stratification continues. Moreover, important data on use osimertinib, third-generation epidermal growth factor receptor (EGFR) inhibitor EGFR-mutated were presented, emerging as preferred therapeutic strategy these patients. The ideal treatment sequence,...