A5031535830- Lung Cancer Diagnosis and Treatment
- Esophageal Cancer Research and Treatment
- Lung Cancer Treatments and Mutations
- Esophageal and GI Pathology
- Tracheal and airway disorders
- Pleural and Pulmonary Diseases
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Research Studies
- Diabetic Foot Ulcer Assessment and Management
- Photodynamic Therapy Research Studies
- Nanoplatforms for cancer theranostics
- Dysphagia Assessment and Management
- RNA modifications and cancer
- Heme Oxygenase-1 and Carbon Monoxide
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Ion channel regulation and function
- Trauma Management and Diagnosis
- Pulmonary Hypertension Research and Treatments
- Metastasis and carcinoma case studies
- Cancer Genomics and Diagnostics
- Cardiac, Anesthesia and Surgical Outcomes
- Gastric Cancer Management and Outcomes
- Vitamin D Research Studies
- Respiratory Support and Mechanisms
- Inflammatory Biomarkers in Disease Prognosis
Medical University of Graz
2016-2025
University of Graz
2014-2015
University Clinic of Traumatology
2007
Universitätsklinik für Chirurgie Wien
2006
Federal Department of Home Affairs
1962
Gesundheitsamt
1962
After resective and reconstructive surgery in the gastrointestinal tract, oral feeding is traditionally avoided order to minimize strain anastomoses reduce inherent risks of postoperatively impaired motility. However, studies have given evidence that small bowel recovers its ability absorb nutrients almost immediately following surgery, even absence peristalsis, early enteral would preserve both integrity gut mucosa immunological function. The aim this study was investigate impact on...
The potassium channel TWIK-related acid sensitive (TASK)-1 channel, together with other channels, controls the low resting tone of pulmonary arteries. Src family tyrosine kinase (SrcTK) may control function in human artery smooth muscle cells (hPASMCs) response to changes oxygen tension and clinical use a SrcTK inhibitor has resulted partly reversible hypertension. This study aimed determine role hypoxia-induced inhibition channels hPASMCs. We show that is co-localised TASK-1 channel....
Cannabinoid (CB) receptors (CB 1 and CB 2 ) are expressed on cancer cells their expression influences carcinogenesis in various tumor entities. Cells of the microenvironment (TME) also express receptors, however, role development is still unclear. We, therefore, investigated TME-derived a model non-small cell lung (NSCLC). Leukocytes TME mouse human NSCLC with showing higher than . In model, using - -/- -knockout mice, only deficiency , but not resulted reduction burden vs. wild type (WT)...
Background The use and approval of immune checkpoint inhibitors for the treatment non-small cell lung cancer (NSCLC) depends on PD-L1 expression in tumor tissue. Nevertheless, often fails to predict response treatment. One possible explanation could be a change during course disease neglect reassessment. purpose this study was longitudinal analysis patients with relapsed NSCLC. Methods We retrospectively analyzed early-stage NSCLC subsequent relapse preoperative samples, matched surgical...
Accumulating evidence from experimental and epidemiological studies suggests that vitamin D deficiency might be a causal risk factor for cancer therewith associated mortality. We performed systematic review in Medline up to February 2012 identify prospective on 25-hydroxyvitamin (25[OH]D) mortality as well 25(OH)D survival patients. Our search retrieved 13 cancer-specific 20 overall Data were mainly derived general populations. The results inconsistent yielded either no, inverse or positive...
Background and Objectives Inflammation perpetuates individual tumor progression resulting in decreased survival cancer patients. The aim of our study was to evaluate the influence elevated levels C‐reactive protein (CRP) as well low albumin on patients with inoperable esophageal carcinoma. Methods data 218 advanced cancer, who were treated at a single center within 12 years, evaluated retrospectively. Patient's age, gender, body weight, dysphagia, plasma CRP albumin, Glasgow Prognostic Score...
Introduction: Sternoclavicular joint infections (SCJIs) are extremely rare, making up less than 1% of all septic arthritis cases. This retrospective study aims to evaluate the management and outcomes SCJIs, including both surgical non-surgical approaches. Methods: included 55 patients treated between January 2005 December 2023 at Division Thoracic Hyperbaric Surgery in Graz, Austria. Data on patient characteristics, treatment approach, outcome were analyzed. Results: Out patients, 50...
Objective: The objective of this study is to compare the long-term outcomes femorofemoral crossover bypass (FCOB) and endovascular treatment (ET) in managing iliac artery occlusions. Methods: data 200 patients with lesions who were treated at a single center within 7 years evaluated retrospectively. Of these, 82 (41%) underwent FCOB, 118 (59%) received ET. Primary included patency, limb salvage, survival rates, while secondary assessed complications, including wound infections restenosis....
Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death worldwide. Dysregulation protein synthesis plays a major role in carcinogenesis, process regulated at multiple levels, including translation mRNA into proteins. Ribosome assembly requires correct association ribosome subunits, which ensured by eukaryotic initiation factors (eIFs). eIFs have become targets therapy studies, and promising data on eIF6 various entities been reported. Therefore, we hypothesised that...
Preoperative micronutrient supplementation in fast-track surgery programs have shown to reduce complications, shorten recovery, and thereby lower costs. In a prospective randomized study, the metabolic effects of combination alpha-ketoglutaric acid (alpha-KG) 5-hydroxymethylfurfural (5-HMF) were evaluated concerning their impact on improvement exercise capacity reduction oxidative stress lung surgery.Thirty-two consecutive patients admitted for resection due NSCLC study protocol. All...
The cancer stem cell (CSC) and epithelial-to-mesenchymal transition (EMT) models have been closely associated used to describe both the formation of metastasis therapy resistance. We established a primary lung culture from patient in clinically rare unique situation resistant disease. This consisted two biologically profoundly distinct adenocarcinoma subpopulations, which differed phenotypically genotypically. One subpopulation initiated sustained spheroid (LT22s) whereas other was only...
In esophageal carcinoma palliative treatment is often required due to advanced tumor stage or patient-related factors. The main goal of our retrospective single center study was evaluate the effect an individualized multimodal treatment, focusing on efficacy different options.Between 1999 and 2009, 640 patients suffering from were referred division. Two hundred fifty out those (39.1%) treated with intention by using a individualized, concept including endoscopic dilatation, photodynamic...
Squamous cell and adenocarcinomas of the lung develop different mechanisms during carcinogenesis to evade attacks immune system. Besides well-known check-point control programmed death 1 its ligand, many more mechanisms, acting either tumoricidal or in favor tumor progression, exist. Analysis profiles resected tissues bronchoalveolar lavage samples correlation between them with overall survival data was performed. In all this study, cells system expressed a tumor-cooperating phenotype. High...